Penn Udall Center Publications
As a resource, the following is a listing of recent publications from the researchers and staff at the Penn Udall Center for Parkinson's Research. Where titles are in blue, links are available to either the full article or an abstract.
Current Publications
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Moural C, Brennan L, Rosenthal R, Clark C, Duda J, Hurtig H, Siderowf A. 2008 Safety and Tolerability of Research Lumbar Punctures in Patients with Parkinson’s Disease. Symposium on the Etiology, Pathogenesis and Treatment of Parkinson’s Disease. Salt Lake City, Utah, September 2008. Click to view poster.
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Rosenthal E, Brennan L, Milber J, Hurtig H, Weintraub W, Siderowf A. Impact of Mild Cognitive Deficits on Daily Functioning in Parkinson’s Disease. Movement Disorders Society Poster, Chicago, IL, June 2008. Click to view poster.
- Rosenthal E, Brennan L, Milber J, Hurtig H, Weintraub D, Siderowf A. Impact of Mild Cognitive Deficits on Daily Functioning in Parkinson’s Disease. IOA Retreat Poster 2008, Philadelphia, PA, May 2008.
- Dahodwala N, Connolly J, Farmer J, Stern MB, Jennings D, Siderowf A. Interest in predictive testing for Parkinson’s disease: Impact of neuroprotective therapy. Parkinsonism and Related Disorders (in press).
- Weintraub D, Xie S, Karlawish J, Siderowf A. Differences in Depression Symptoms in Patients with Alzheimer’s and Parkinson’s Diseases: Evidence From the 15-Item Geriatric Depression Scale (GDS-15). International Journal of Geriatric Psychiatry. (in press).
- Weintraub D, Hurtig H. Presentation and Management of Psychosis in Parkinson’s Disease and Dementia with Lewy Bodies. Am J Psych (in press).
- Weintraub D, Hurtig H. Presentation and Management of Psychosis in Parkinson’s Disease and Dementia with Lewy Bodies. Am J Psych (in press).
- Chen-Plotkin A, Yuan W, Anderson C, McCarty-Wood E, Hurtig HI, Lee VM-Y, Trojanowski JQ, Grossman M, Van Deerlin, V. Frontotemporal dementia as a manifestation of two different LRRK2 gene mutations. Neurol., In press, 2007.
- Jedrziewski MK, Lee VM-Y, Trojanowski JQ. Physical activity and cognitive health. Alzheimer’s & Dementia, 3:98-108, 2007.
- Lippa CF, Duda JE, Grossman M, Hurtig H, Aarsland D, Boeve B, Brooks DJ, Dickson DW, Dubois B, Emre M, Fahn S, Farmer J, Galasko D, Galvin JE, Goetz C, Growdon JH, Gwinn-Hardy KA, Hardy J, Heutink P, Iwatsubo T, Kosaka K, Lee VM-Y, Leverenz J, Masliah E, McKeith IE, Nussbaum RL, Olanow CW, Ravina BM, Singleton AB, Tanner CM, Trojanowski JQ, Wszolek ZK, DLB/PDD Working Group. DLB and PDD boundary issues: Diagnosis, treatment, molecular pathology and biomarkers. Neurol., 68:812-819, 2007.
- Murray R, Neumann M, Forman MS, Farmer J,Massimo L, Rice A,Miller BL, Johnson JK, Clark CM, Hurtig HI, Gorno-Tempini ML, Lee VM, Trojanowski JQ, Grossman M. Cognitive and motor assessment in autopsy-proven corticobasal degeneration. Neurology. 68 (16):1274-83, 2007.
- Nakashima-Yasuda H, Uryu K, Robinson J, Xie SX, Hurtig H, Duda J, Leverenz JB, Lopez O, Hamilton R, Tsuang DW, Galasko D, Masliah E, Kaye J, Woltjer R, Clark CM, Montine TJ, Lee VM –Y, Trojanowski JQ. Co-morbidity of TDP-43 Proteinopathy in Lewy body diseases. Acta Neuropathol, In press, 2007.
- Norris EH, Uryu K, Leight S, Giasson BI, Trojanowski JQ, Lee VM-Y. Oxidative damage by paraquat exacerbates neuropathology in an A53T transgenic mouse model of alpha-synucleinopathy. Am J Pathol, 170:658-666, 2007.
- Novais-Santos S, Gee J, Shah MS, Troiani V, Work M, Grossman M. Resolving sentence ambiguity with planning and working memory resources: Evidence from fMRI. NeuroImage 37:361-378, 2007.
- Ramsey CP, Giasson BI. Role of mitochondrial dysfunction in Parkinson's disease: Implications for treatment. Drugs Aging, 24:95-105, 2007.
- Shaw LM, Korecka M, Clark CM, Lee VM.-Y, Trojanowski JQ. Biomarkers of neurodegeneration for diagnosis and monitoring therapeutics. Nat Rev Drug Discovery, 6:295-303, 2007.
- Ash S, Moore P, Antani S, McCawley G, Work M, Grossman M. Trying to tell a tale: Discourse impairments in progressive aphasia and frontotemporal dementia. Neurol, 66:1405-1413, 2006.
- Clark CM, Pratico D, Shaw L, Leight S, Xie S, Gu A, Lee V-M, Trojanowski JQ. Biochemical biomarkers of late-life dementia. Alzheimer’s & Dementia,2:287-293, 2006.
- Cosentino S, Chute D, Libon D, Moore P, Grossman M. How does the brain represent scripts?: A study of executive processes and semantic knowledge in dementia. Neuropsychol, 20:307-318, 2006.
- Fan Y, Limprasert P, Murray IVJ, Smith AC, Lee VM-Y, Trojanowski JQ, Sopher BL, La Spada AR. Beta-synuclein modulates alpha-synuclein neurotoxicity by reducing alpha-synuclein protein expression. Hum Molec Genet, 15:3002-3011, 2006.
- Giasson BI, Covy J, Bonini NM, Hurtig HI, Farrer MJ, Trojanowski JQ, Van Deerlin V. Biochemical and pathological characterization of LRRK2. Ann Neurol, 59:315-322, 2006.
- Goker-Alpan O, Giasson BI, Eblan MJ, Nguyen J, Hurtig HI, Lee VM-Y,Trojanowski JQ, Sidranskey E. Glucocerebrosidase mutations are an important risk factor for Lewy body disorders. Neurol, 67:908-910, 2006.
- Lee VMY, Trojanowski JQ. Mechanisms of Parkinson’s disease linked to pathological alpha-synuclein: New targets for drug discovery. Neuron, 52:33-38, 2006.
- Mazzulli JR, Mishizen AJ, Giasson BI, Lynch DR, Thomas SA, Nakashima A, Nagatsu T, Ota A, Ischiropoulos H. Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates. J Neurosci, 26:10068-10078, 2006.
- Siderowf A, Jaggi J, Xie SX, Loveland-Jones C, Leng L, Hurtig H, Colcher A, Stern M, Chou CL, Liang G, Maccarone H, Simuni T, Baltuch G. Long-term effects of bilateral sub-thalamic nucleus stimulation on health-related quality-of-life in advanced Parkinson’s disease. Movement Disorders. 21: 746-753, 2006.
- Uryu K, Richter-Landsberg C, Welch W, Sun E, Goldbaum O, Norris EH,PhamC-T, Yazawa I, Hilburger K, Miscenyi M, Giasson BI, Bonini NM, Lee VM-Y, Trojanowski JQ. Convergence of Hsp90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies. Am J Pathol, 168:947-961, 2006.