Penn Udall Center Publications

As a resource, the following is a listing of publications from the researchers and staff at the Penn Udall Center for Parkinson's Research. Where titles are in blue, links are available to either the full article or an abstract.

Current Publications

• Siderowf, A., Xie, S.X., Hurtig, H., Weintraub, D., Duda, J., Chen-Plotkin, A., Shaw, L.M., Van Deerlin, V., Trojanowski, J.Q., and Clark, C.M. CSF amyloid β 1-42 predicts cognitive decline in Parkinson’s disease. Neurol., 75:1055-1061, 2010.
• Chen-Plotkin, A., Hu,W.T., Siderowf, A., Weintraub, D, Goldmann Gross, R., Hurtig, H.I., Xie, S., Arnold, S.E., Grossman,M., Clark, C.M., Shaw, L.M., McCluskey, L., Elman, L.,Karlawish, J., Van Deerlin, V.M., Lee, V.M.-Y., Soares, H., and Trojanowski, J.Q. Plasma EGF levels correlate with cognitive performance and predict cognitive impairment in Parkinson’s disease. Ann. Neurol., In press, 2010.
• Hu,W.T., Chen-Plotkin, A., Arnold, S.E., Grossman,M., Clark, C.M., Shaw, L.M., McCluskey, L., Elman, L., Karlawish, J., Hurtig, H.I., Siderowf, A., Lee, V.M.-Y., Soares, H., and Trojanowski, J.Q. Biomarker discovery for Alzheimer’s disease, frontotemporal lobar degeneration, and Parkinson’s disease. Acta Neuropathol., 120:385-399, 2010.
• Peelle, J. E., Troiani, V., Grossman, M.: Interaction between process and content in semantic memory: An fMRI study of noun feature knowledge.  Neuropsychologia 47:995-1003, 2009. PMC2675540
• Peelle, J.E., Troiani, V., Gee, J., Moore, P., McMillan, C., Vesely, L., Grossman, M.: Sentence comprehension and voxel-based morphometry in progressive nonfluent aphasia, semantic dementia, and nonaphasic frontotemporal dementia.  Journal of Neurolinguistics 21:418-432, 2008. PMC2598754
• Ash, S., Moore, P., Vesely, L., Gunawardena, D., McMillan, C., Anderson, C., Avants, B., Grossman, M.: Non-fluent speech in frontotemporal lobar degeneration.  Journal of Neurolinguistics 22:370-383, 2009. PMC20074786
• Listerud, J., Anderson, C., Moore, P., Libon, D.J., Grossman, M.: Neuropsychological patterns in MRI-defined subgroups of patients with degenerative dementia.  Journal of the International Neuropsychological Society 15:459-470, 2009.
• Das, S.R., Avants, B.B., Grossman, M., Gee, J.C.: Registration-based cortical thickness measurement.  NeuroImage 45:867-879, 2009. PMC19150502
• Whitney, C., Weis, S., Krings, T., Huber, W., Grossman, M., Kircher, T.: Task-dependent modulations of prefrontal and hippocampal activity during intrinsic word production.  Journal of Cognitive Neuroscience 21:697-712, 2009.
• Grossman, M.: Primary progressive aphasia: Clinical-pathological correlations.  Nature Reviews Neurology 6;88-97, 2010. PMC20139998
• Avants, B., Cook, P.A., Ungar, L., Gee, J.C., Grossman, M.: Dementia induces correlated reductions in white matter integrity and cortical thickness: A multivariate neuroimaging study with sparse canonical correlation analysis.  NeuroImage 50;1004-1016, 2010. PMC20083207
• Yu, C.-E., Bird, T.D., Bekris, L.M., Leverenz, J.B., Steinbart, E., Galloway, N.M., Feldman, H., Woltjer, R., Miller, C.A., Wood, E.M.,, Grossman, M.,  McCluskey L., Clark C.M., Neumann, M., Danek, A., Galasko, D.R., Arnold, S.E., Chen-Plotkin, A., Karydas, A., Miller, B.L., Trojanowski, J.Q., Lee, V.M.-Y.,  Schellenberg, G.D., Van Deerlin, V.M. The spectrum of mutations in progranulin: A collaborative study screening 545 cases of neurodegeneration. Arch. Neurol., 67:161-170, 2010. PMC20142524
• Luk, K.C., Song, C., O’Brien, P., Stieber, A., Branch, J., Brunden, K.R., Trojanowski, J.Q., and Lee, V.M.-Y. Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells. Proc. Nat. Acad. Sci., 106:20051-20056, 2009. PMC2785290
• Lim, Y., Kehm, V., Li, C., Trojanowski, J.Q., and Lee, V. M.-Y. Forebrain overexpression of alpha-synuclein leads to early postnatal hippocampal neuron loss and synaptic disruption. Exper. Neurol., 221:86-97, 2010. PMC2812632
• Roy, S., Lee, V.M.-Y., and Trojanowski, J.Q. Axonal transport and neurodegenerative diseases. In: Handbook Of The Neuroscience Of Aging, P.R. Hof, and C.V. Mobbs (Eds.), Elsevier Academic Press, pp. 107-112, 2009.
• Waxman, E.A., Covy, J.P., Bukh, I., Li, X., Dawson, T.M., Giasson B.I. Overexpression of leucine-rich repeat kinase 2 leads to aggresome-like formation, but it is not associated with α-synuclein aggregation or pathological inclusions.  J. Neuropath. Exp. Neurol. 68, 785-96, 2009. PMC2722758
• Waxman, E.A., Mazzulli, J.R., Giasson, B.I. Characterization of hydrophobic residue requirements for α-synuclein fibrillization. Biochemistry, 48, 9427-9436, 2009. PMC2758333
• Waxman, E.A., Emmer, K.L., Giasson, B.I. Residues Glu83 plays a major role in negatively regulating α-synuclein amyloid formation. Biochem. Biophys. Res. Commun. 391, 1415-1420, 2010. PMC2812690
• Moural C, Brennan L, Rosenthal R, Clark C, Duda J, Hurtig H, Siderowf A. 2008 Safety and Tolerability of Research Lumbar Punctures in Patients with Parkinson’s Disease. Symposium on the Etiology, Pathogenesis and Treatment of Parkinson’s Disease. Salt Lake City, Utah, September 2008. Click to view poster.
• Rosenthal E, Brennan L, Milber J, Hurtig H, Weintraub W, Siderowf A. Impact of Mild Cognitive Deficits on Daily Functioning in Parkinson’s Disease. Movement Disorders Society Poster, Chicago, IL, June 2008. Click to view poster.
• Rosenthal E, Brennan L, Milber J, Hurtig H, Weintraub D, Siderowf A. Impact of Mild Cognitive Deficits on Daily Functioning in Parkinson’s Disease. IOA Retreat Poster 2008, Philadelphia, PA, May 2008.
• Dahodwala N, Connolly J, Farmer J, Stern MB, Jennings D, Siderowf A. Interest in predictive testing for Parkinson’s disease: Impact of neuroprotective therapy. Parkinsonism and Related Disorders (in press).
• Weintraub D, Xie S, Karlawish J, Siderowf A. Differences in Depression Symptoms in Patients with Alzheimer’s and Parkinson’s Diseases: Evidence From the 15-Item Geriatric Depression Scale (GDS-15). International Journal of Geriatric Psychiatry. (in press).
• Weintraub D, Hurtig H. Presentation and Management of Psychosis in Parkinson’s Disease and Dementia with Lewy Bodies. Am J Psych (in press).
• Weintraub D, Hurtig H. Presentation and Management of Psychosis in Parkinson’s Disease and Dementia with Lewy Bodies. Am J Psych (in press).
• Chen-Plotkin A, Yuan W, Anderson C, McCarty-Wood E, Hurtig HI, Lee VM-Y, Trojanowski JQ, Grossman M, Van Deerlin, V. Frontotemporal dementia as a manifestation of two different LRRK2 gene mutations. Neurol., In press, 2007.
• Jedrziewski MK, Lee VM-Y, Trojanowski JQ. Physical activity and cognitive health. Alzheimer’s & Dementia, 3:98-108, 2007.
• Lippa CF, Duda JE, Grossman M, Hurtig H, Aarsland D, Boeve B, Brooks DJ, Dickson DW, Dubois B, Emre M, Fahn S, Farmer J, Galasko D, Galvin JE, Goetz C, Growdon JH, Gwinn-Hardy KA, Hardy J, Heutink P, Iwatsubo T, Kosaka K, Lee VM-Y, Leverenz J, Masliah E, McKeith IE, Nussbaum RL, Olanow CW, Ravina BM, Singleton AB, Tanner CM, Trojanowski JQ, Wszolek ZK, DLB/PDD Working Group. DLB and PDD boundary issues: Diagnosis, treatment, molecular pathology and biomarkers. Neurol., 68:812-819, 2007.
• Murray R, Neumann M, Forman MS, Farmer J,Massimo L, Rice A,Miller BL, Johnson JK, Clark CM, Hurtig HI, Gorno-Tempini ML, Lee VM, Trojanowski JQ, Grossman M. Cognitive and motor assessment in autopsy-proven corticobasal degeneration. Neurology. 68 (16):1274-83, 2007.

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• Nakashima-Yasuda H, Uryu K, Robinson J, Xie SX, Hurtig H, Duda J, Leverenz JB, Lopez O, Hamilton R, Tsuang DW, Galasko D, Masliah E, Kaye J, Woltjer R, Clark CM, Montine TJ, Lee VM –Y, Trojanowski JQ. Co-morbidity of TDP-43 Proteinopathy in Lewy body diseases. Acta Neuropathol, In press, 2007.
• Norris EH, Uryu K, Leight S, Giasson BI, Trojanowski JQ, Lee VM-Y. Oxidative damage by paraquat exacerbates neuropathology in an A53T transgenic mouse model of alpha-synucleinopathy. Am J Pathol, 170:658-666, 2007.
• Novais-Santos S, Gee J, Shah MS, Troiani V, Work M, Grossman M. Resolving sentence ambiguity with planning and working memory resources: Evidence from fMRI. NeuroImage 37:361-378, 2007.
• Ramsey CP, Giasson BI. Role of mitochondrial dysfunction in Parkinson's disease: Implications for treatment. Drugs Aging, 24:95-105, 2007.
• Shaw LM, Korecka M, Clark CM, Lee VM.-Y, Trojanowski JQ. Biomarkers of neurodegeneration for diagnosis and monitoring therapeutics. Nat Rev Drug Discovery, 6:295-303, 2007.
• Ash S, Moore P, Antani S, McCawley G, Work M, Grossman M. Trying to tell a tale: Discourse impairments in progressive aphasia and frontotemporal dementia. Neurol, 66:1405-1413, 2006.
• Clark CM, Pratico D, Shaw L, Leight S, Xie S, Gu A, Lee V-M, Trojanowski JQ. Biochemical biomarkers of late-life dementia. Alzheimer’s & Dementia,2:287-293, 2006.
• Cosentino S, Chute D, Libon D, Moore P, Grossman M. How does the brain represent scripts?: A study of executive processes and semantic knowledge in dementia. Neuropsychol, 20:307-318, 2006.
• Fan Y, Limprasert P, Murray IVJ, Smith AC, Lee VM-Y, Trojanowski JQ, Sopher BL, La Spada AR. Beta-synuclein modulates alpha-synuclein neurotoxicity by reducing alpha-synuclein protein expression. Hum Molec Genet, 15:3002-3011, 2006.
• Giasson BI, Covy J, Bonini NM, Hurtig HI, Farrer MJ, Trojanowski JQ, Van Deerlin V. Biochemical and pathological characterization of LRRK2. Ann Neurol, 59:315-322, 2006.
• Goker-Alpan O, Giasson BI, Eblan MJ, Nguyen J, Hurtig HI, Lee VM-Y,Trojanowski JQ, Sidranskey E. Glucocerebrosidase mutations are an important risk factor for Lewy body disorders. Neurol, 67:908-910, 2006.
• Lee VMY, Trojanowski JQ. Mechanisms of Parkinson’s disease linked to pathological alpha-synuclein: New targets for drug discovery. Neuron, 52:33-38, 2006.

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• Mazzulli JR, Mishizen AJ, Giasson BI, Lynch DR, Thomas SA, Nakashima A, Nagatsu T, Ota A, Ischiropoulos H. Cytosolic catechols inhibit alpha-synuclein aggregation and facilitate the formation of intracellular soluble oligomeric intermediates. J Neurosci, 26:10068-10078, 2006.
• Siderowf A, Jaggi J, Xie SX, Loveland-Jones C, Leng L, Hurtig H, Colcher A, Stern M, Chou CL, Liang G, Maccarone H, Simuni T, Baltuch G. Long-term effects of bilateral sub-thalamic nucleus stimulation on health-related quality-of-life in advanced Parkinson’s disease. Movement Disorders. 21: 746-753, 2006.
• Uryu K, Richter-Landsberg C, Welch W, Sun E, Goldbaum O, Norris EH,PhamC-T, Yazawa I, Hilburger K, Miscenyi M, Giasson BI, Bonini NM, Lee VM-Y, Trojanowski JQ. Convergence of Hsp90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies. Am J Pathol, 168:947-961, 2006.

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