Department of Psychiatry
Penn Behavioral Health

Unit for Experimental Psychiatry Division of Sleep and Chronobiology

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Selected Publications

Spaeth, A.M., Dinges, D.F., Goel, N.: Effects of sleep restriction on weight gain, caloric intake and meal timing in healthy adults. SLEEP 36: 981-990, 2013PDF Document

Minkel, J.D., et al. Dinges, D.F. Sleep deprivation potentiates HPA axis stress reactivity in healthy adults to health psychology. Health Psychology (under revision).

Spaeth, A., Goel, N., Dinges, D.F. Managing neurobehavioral capability when social expediency trumps biological imperatives. Progress in Brain Research 199:377-398, 2012 (Kalsbeek A, Merrow M, Roenneberg T, Foster RG, editors) PMID:22877676PDF Document

Minkel, J.D., Banks, S. Htaik, O., Moreta, M.C., Jones, C.W., McGlinchey, E.L., Simpson, N.S., Dinges, D.F. Sleep deprivation and stress: evidence for a lower threshold for subjective stress when sleep deprived. Emotion Feb 6, 2012; e-pub, doi: 10.1037/a0026871.

Ye, L., Pack, A.I., Maislin, G., Dingesm D.F., Hurley, S., McCloskey, S., Weaver, T.E. Predictors of continuous positive airway pressure use during the first week of treatment. Journal of Sleep Research 21(4):419-426, 2012. doi: 10.1111/j.1365-2869.2011.00969.x.PDF Document

Goel, N. Dinges, D.F. Predicting risk in space: Genetic markers for differential vulnerability to sleep restriction. Acta Astronautica 77:207-213, 2012. doi: 10.1016/j.actaastro.2012.04.002

Lim, J., Ebstein, R., Tse, C.Y., Monakhov, M., Lai, P.S., Dinges, D.F., Kwoka, K.
Dopaminergic polymorphisms associated with time-on-task declines and subjective fatigue during the Psychomotor Vigilance Test. PLoS ONE 2012;7(3):e33767. Epub 2012 Mar 16.

Gunzelman, G., Gluck, K.A., Moore, R.L., Dinges, D.F. Diminished access to declarative knowledge with sleep deprivation. Cognitive Systems Research 13:1–11, 2012. doi:10.1016/j.cogsys.2010.09.001

Van Dongen, H.P.A., Bender, A.M., Dinges, D.F. Systematic individual differences in sleep homeostatic and circadian rhythm contributions to neurobehavioral impairment during sleep deprivation. Accident Analysis and Prevention, 45S:11-16, 2012,
doi:10.1016/j.aap.2011.09.018. PMID: 22239924 PMCID: PMC3260461

Basner, M., Dinges, D.F. An adaptive-duration version of the PVT accurately tracks
changes in psychomotor vigilance induced by sleep restriction. SLEEP 35(2):193-202,
2012. doi: 10.5665/sleep.162. PMID: 22294809. PMCID: PMC3250358

Goel, N., Banks, S., Lin, L., Mignot, E., Dinges, D.F. Catechol-O-Methyltransferase
Val158Met polymorphism associates with individual differences in sleep physiologic
responses to chronic sleep loss. PLoS ONE, 6(12):1-10, 27 December 2011. PMCID:
PMC3246458

Goel, N., Dinges, D.F. Behavioral and genetic markers of sleepiness. Journal of Clinical Sleep Medicine. 7(5): S19-S21, 2011.  PMID:  22003324  PMCID:  PMC3190416 PDF Document

Basner, M., Mollicone, D., Dinges, D.F. Validity and sensitivity of a Brief Psychomotor Vigilance Test (PVT-B) to total and partial sleep deprivation. Acta Astronautica (in press) doi:10.1016/j.actaastro.2011.07.015.PDF Document

Basner, M., Dinges, D.F. Maximizing sensitivity of the Psychomotor Vigilance Test (PVT) to sleep loss. SLEEP 34(5):581-591, 2011. PDF Document

Basner, M., Dinges, D.F. Maximizing sensitivity of the Psychomotor Vigilance Test (PVT) to sleep loss. SLEEP (in press).

Minkel, J.D., Htaik, O., Banks, S., Dinges, D.F. A night of sleep deprivation reduces the intensity of emotional expressions in healthy adults. Behavioral Sleep Medicine, 9:5-14, 2011. DOI:10.1080/15402002.2011.533987

Simpson, N.S., Banks, S., Arroyo, S., Dinges, D.F. Effects of sleep restriction on adiponectin levels in healthy men and women. Physiology and Behavior 101:693-698, 2010. PMID:20723551

Goel, N., Banks, S., Mignot, E., Dinges, D.F. DQB1*0602 Predicts interindividual differences in physiological sleep, sleepiness and fatigue. Neurology 75:1509-1519, 2010. PMID:20975052

Banks, S., Van Dongen, H.P.A., Maislin, G., Dinges, D.F. Neurobehavioral dynamics following chronic sleep restriction: Dose-response effects of one night for recovery. SLEEP 33(8):1013-1026, 2010.

Mollicone, D.J., Van Dongen, H., Rogers, N.L., Banks, S., Dinges, D.F.: Time of day modulates the effects of chronic sleep restriction on neurobehavioral performance. Aviation, Space & Environmental Medicine, 81: 735-744, August, 2010.

Lim, J., Wu, W-C, Wang, J., Detre, J.A., Dinges, D.F., Rao, H. Imaging brain fatigue from sustained mental workload: An ASL perfusion study of the time-on-task effect, NeuroImage, 49(4): 3426-3435, 2010.

Lim, J., Tan, J.C., Parimal, S., Dinges, D.F., Chee, M.W.L. Sleep deprivation impairs object-selective attention: A view from the ventral visual cortex. PLoS ONE www.plosone.org, February 5, 2010.

Goel, N. Rao, H., Durmer, J., Dinges, D.F.: Neurocognitive consequences of sleep deprivation. Seminars in Neurology, 29(4): 320-339, 2009.

Goel, N., Banks, S., Mignot, E., Dinges, D.F.: PER3 polymorphism predicts cumulative sleep homeostatic but not neurobehavioral changes to chronic partial sleep deprivation. PLoS ONE www.plosone.org 4(6):e5874, June 2009.

Goel, N., Stunkard, A.J., Rogers, N.L., Van Dongen, H.P.A., Allison, K.C., O’Reardon, J.P., Ahima, R.S., Cummings, D.E., Moonseong Heo, Dinges, D.F.: Circadian rhythm profiles in women with Night Eating Syndrome. Journal of Biological Rhythms 24(1):85-94, 2009. PMID:19150931

McCauley, P, Kalachev, L.V., Smith, A.D., Belenky, G., Dinges, D.F., Van Dongen, H.: A new mathematical model for the homeostatic effects of sleep loss on neurobehavioral performance. Journal of Theoretical Biology 256:227–239, 2009. PMID:18938181

Gunzelmann, G., Gross, J.B., Gluck, K.A., Dinges, D.F. Sleep deprivation and sustained attention performance: Integrating mathematical and cognitive modeling. Cognitive Science, 33(5), 880-910, 2009. PMID:21585489

Gunzelmann, G., Moore, L. R., Gluck, K. A., Van Dongen, H. P. A., Dinges, D.F., Individual differences in sustained vigilant attention: Insights from computational cognitive modeling. In B.C. Love, K. McRae, V. M. Sloutsky (Eds.), Proceedings of the Thirtieth Annual Meeting of the Cognitive Science Society, Austin, TX: Cognitive Science Society, 2017-2022, 2008.

Mollicone, D.J., Van Dongen, H.P.A., Rogers, N.L., Dinges, DF. Response surface mapping of neurobehavioral performance: testing the feasibility of split sleep schedules for space operations. Acta Astronautica 63(7-10): 833-840, 2008. doi: 10.1016/j.actaastro.2007.12.005

Basner, M., Rubinstein, J., Fomberstein, K.M., Coble, M.C., Ecker, A., Avinash, D., Dinges, D.F., Effects of night work, sleep loss and time on task on simulated threat detection performance. Sleep, 31(9):1251-1259, 2008. PMID:18788650

Chee MLW, Tan CH, Hui Z, Parimal S, Weissman SD, Zagorodnov V, Dinges DF. Lapsing during sleep deprivation is associated with distributed changes in brain activation. J Neurosci, 28(21):5519-5528, May 21, 2008.Click Here to View PDF

Lim J, Dinges DF. Sleep deprivation and vigilant attention. Annals N Y Acad Sci, 1129:305-322, 2008.Click Here to View PDF

Simpson, N., Dinges, D.F.: Sleep and inflammation. Nutrition Reviews. II: S244–S252, December 2007. PMID:18240557

Scott, L.D., Hwang, W.-T., Rogers , A.E., Nysse, T., Dean, G.E., Dinges, D.F.: The relationship between nurse work schedules, sleep duration, and drowsy driving. Sleep, 30(12):1801-1807, 2007. PMID:18246989

Kim , H., Dinges, D.F., Young , T.: Sleep-disordered breathing and psychomotor vigilance in a community-based sample. Sleep, 30(10):1309-1316, 2007. PMID:17969464

Tucker, A.M., Dinges, D.F., Van Dongen, H.P.A.: Trait inter-individual differences in the sleep physiology of healthy young adults. Journal of Sleep Research, 16:1-11, 2007. PMID:17542947

Banks, S., Dinges, D.F.: Behavioral and physiological consequences of sleep restriction in humans. Journal of Clinical Sleep Medicine 3(5):519-528, 2007. PMID:17803017

Van Dongen, H.P.A., Mott, C.G., Huang, J-K, Mollicone, D.J., McKenzie, F.D., Dinges, D.F : Optimization of biomathematical model predictions for cognitive performance impairment in individuals: accounting for unknown traits and uncertain states in homeostatic and circadian processes running head: performance prediction in individuals . Sleep 30(9): 1125-1139, 2007. PMID:17910385

Basner, M., Fomberstein, K., Razavi, F.M., William, J., Simpson, N., Rosa, R., Dinges, D.F : American Time Use Survey: Sleep time and its relationship to waking activities. Sleep 30(9): 1081-1091, 2007. PMID:17910380

Weaver, T.E., Maislin, G., Dinges, D.F., Bloxham, T., George, C., Greenberg, H., Kader, G., Mahowald, M., Younger, J., Pack, A.I.: Relationship between hours of CPAP use and achieving normal levels of sleepiness and daily functioning. Sleep, 30(6):711-719, 2007. PMID:17580592

Mollicone, D.J., Van Dongen, H., Dinges, D.F.: Optimizing sleep/wake schedules in space: Sleep during chronic nocturnal sleep restriction with and without diurnal naps. Acta Astronautica, 60:354-361, 2007.

Dinges, D.F., Venkataraman, S., McGlinchey, E.L., Metaxas, D.N : Monitoring of facial stress during space flight: Optical computer recognition combining discriminative and generative methods . Acta Astronautica 60: 341-350, 2007.

Scott, L.D., Hwang, W.-T., Rogers, A.E., Nysse, T., Dean, G.E., Dinges, D.F : The relationship between nurse work schedules, sleep duration, and drowsy driving. Sleep 3(12): 1801 - 1807, 2007. Click Here to View PDF


Chee, M.W.L., Chuah, L.Y.M., Venkatraman, V., Chan, W.Y., Philip, P., Dinges, D.F : Functional imaging of working memory following normal sleep and after 24 and 35 h of sleep deprivation: Correlations of fronto-parietal activation with performance. NeuroImage 31: 419-428, 2006. Click Here to View PDF

Chuah, Y.M.L., Venkatraman, V., Dinges, D.F., Chee, M.W.L : The neural basis of inter-individual variability in inhibitory efficiency following sleep deprivation. The Journal of Neuroscience 26(27): 7156-7162, 2006. Click Here to View PDF


Pack, A.I., Maislin, G., Pack, F.M., George, C., Staley, B., Rogers, W., George, C.F.P., Dinges, D.F.: Impaired performance in commercial drivers: Role of sleep apnea and sleep duration. American Journal of Respiratory and Critical Care Medicine, 174:446-454, 2006. PMID:16690976

Dinges, D.F.: Cocoa flavanols, cerebral blood flow, cognition, and health: Going forward. Journal of Cardiovascular Pharmacology, 47(2): S221-S223, 2006.

Chuah, Y.M.L., Venkatraman, V., Dinges, D.F., Chee, M.W.L.: The neural basis of inter-individual variability in inhibitory efficiency following sleep deprivation. The Journal of Neuroscience, 26(27):7156-7162, 2006. PMID:16822972

Ellenbogen, J.M., Hulbert, J.C., Stickgold, R., Dinges, D.F., Thompson-Schill, S.L.: Interfering with theories of sleep and memory: sleep, declarative memory, and associative interference. Current Biology, 16:1290-1294, 2006. PMID:16824917

Pack, A.I., Dinges, D.F, Gehrman, P.R., Staley, B., Pack, F.M., Maislin, G.: Risk factors for excessive sleepiness in older adults. Annals of Neurology, 59:893-904, 2006. PMID:16718691

Dinges, D.F., Arora, S., Darwish, M., Niebler, G.E.: Pharmacodynamic effects on alertness of single doses of armodafinil in healthy subjects during a nocturnal period of acute sleep loss. Current Medical Research and Opinions, 22(1): 159-167, 2006. PMID:16393442

Chee, M.W.L., Chuah, L.Y.M., Venkatraman, V., Chan, W.Y., Philip, P., Dinges, D.F.: Functional imaging of working memory following normal sleep and after 24 and 35 h of sleep deprivation: Correlations of fronto-parietal activation with performance. NeuroImage, 31: 419-428, 2006.

Rogers, N.L., Dinges, D.F., Maislin, G., Allison, K.C., Martino, N.S., O'Reardon, J.P., Stunkard, A.J.: Assessment of sleep in women with night eating syndrome. Sleep, 29(6), 814-819, 2006.

Allison, K.C., Ahima, R., O'Reardon, J.P., Dinges, D.F., Sharma, V., Cummings, D.E., Heo, M., Martino, N.S., Stunkard, A.J.: Neuroendocrine profiles associated with energy intake, sleep and stress in the night eating syndrome. Journal of Clinical Endocrinology and Metabolism 90 (11): 6214-6217, 2005. PMID:16131578

Avinash, D., Crudele, C.P., Amin, D., Robinson, B.M., Dinges, D.F., Van Dongen, H.P.: Parameter estimation for a biomathematical model of psychomotor vigilance performance under laboratory conditions of chronic sleep restriction. Sleep-Wake Research in The Netherlands 16: 39-42, 2005.

Czeisler, C.A., Walsh, J.K., Roth, T., Hughes, R.J., Wright, K.P., Kingsbury, L., Arora, S., Schwartz, J.R.L., Niebler, G., Dinges, D.F.: Modafinil for excessive sleepiness associated with shift work sleep disorder. New England Journal of Medicine, 353:476-486, 2005. PMID:16079371

Dinges, D.F., Maislin, G. Brewster, R.M., Krueger, G.P., Carroll, R.J.:Pilot test of fatigue management technologies. Journal of the Transportation Research Board No. 1922, Transportation Research Board of the National Academies, Washington, DC, 175-182, 2005.Click Here to View PDF

Dinges, D.F., Rider, R.L., Dorrian, J., McGlinchey, E.L., Rogers, N.L., Cizman, Z., Goldenstein, S.K., Vogler, C., Venkataraman, S., Metaxas, D.N.: Optical computer recognition of facial expressions associated with stress induced by performance demands. Aviation, Space & Environmental Medicine 76(6): B172-182, 2005. PMID:15943210

Dorrian J, Rogers NL, Dinges DF. Psychomotor vigilance performance: A neurocognitive assay sensitive to sleep loss. In: Kushida C (Ed), Sleep Deprivation: Clinical Issues, Pharmacology and Sleep Loss Effects. Marcel Dekker, Inc., NY, pp. 39-70, 2005. Click Here to View PDF

Drummond, S.P.A., Bischoff-Grethe, A., Dinges, D.F., Ayalon, L., Mednick, S.C., Meloy, M.J.: The neural basis of the psychomotor vigilance task. Sleep 28(9):1059-1068, 2005.Click Here to View PDF

Durmer, J.S. and Dinges, D.F.: Click Here to View PDF Neurocognitive consequences of sleep deprivation. Seminars in Neurology, 25(1): 117-129, 2005.

Hoffman, J.M., Van Dongen, H.P.A., Dinges, D.F.: Time of day and sleep inertia effects on cognitive performance and sleepiness during chronic sleep restriction. Sleep-Wake Research in The Netherlands, 16: 75-78, 2005.

Rogers, N.L., Dinges, D.F.: Caffeine: Implications for alertness in athletes. Journal for Clinics in Sports Medicine 24:1-13, 2005. PMID:15892913

Van Dongen, H.P.A., Dinges, D.F.: Sleep, circadian rhythms, and psychomotor vigilance performance. Journal for Clinics in Sports Medicine 24:237-249, 2005. PMID:15892921

Whitehouse, W.G., Orne, E.C., Dinges, D.F., Bates, B.L., Nadon, R., Orne, M.T.: The cognitive interview: Does it successfully avoid the dangers of forensic hypnosis? American Journal of Psychology 118(2): 215-234, 2005. PMID:15989121

Wang, J., Wetmore, G.S., Rao, H., Furlan, P.M., Korczykowski, M.. Dinges, D.F., Detre, J.A.: The stressed brain - perfusion fMRI reveals cerebral blood flow pattern under psychological stress. Proceedings of the National Academy of Sciences 102(49): 17804-17809, 2005.

Mallis, MM, Mejdal, S, Nguyen, TT, Dinges, DF.Summary of the key features of seven biomathematical models of human fatigue and performance. Aviation, Space, and Environmental Medicine 75: A4-A14, 2004.Summary of the key features of seven biomathematical models of human fatigue and performance. Aviation, Space, and Environmental Medicine 75 Section II: A4-A14, 2004.

Meier-Ewert, HK, Ridker, PM, Rifai, N, Regan, MM, Price, NJ, Dinges, DF, Mullington, JM.Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. Journal of the American College of Cardiology 43: 678-683, 2004.Click Here to View PDF

Olofsen, E, Dinges, DF, Van Dongen, HPA.Non-linear mixed effects modeling: Individualization and prediction. Aviation, Space, and Environmental Medicine 75: A134-A140, 2004.Click Here to View PDF

Van Dongen HPA.Comparison of mathematical model predictions to experimental data of fatigue and performance. Aviation, Space, and Environmental Medicine 75: A15-A36, 2004.Click Here to View PDF

Van Dongen, HPA, Baynard, MD, Maislin, G, Dinges, DF.Systematic interindividual differences in neurobehavioral impairment from sleep loss: Evidence of trait-like differential vulnerability. Sleep 27: 423-433, 2004.Click Here to View PDF

Van Dongen, HPA, Maislin, G, Dinges, DF.Dealing with inter-individual differences in the temporal dynamics of fatigue and performance: Importance and techniques. Aviation, Space, and Environmental Medicine 75: A147-A154, 2004.Click Here to View PDF

Dinges, DF, Weaver, TE. Effects of modafinil on sustained attention performance and quality of life in OSA patients with residual sleepiness while being treated with nCPAP. Sleep Medicine 4: 393-402, 2003. PMID:14592280

Mullington, JM, Chan, JL, Van Dongen, HPA, Szuba, MP, Samaras, J, Price, NJ, Meier-Ewert, HK, Dinges, DF, Mantzoros, CS.Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men. Journal of Neuroendocrinology 15: 851-854, 2003.Click Here to View PDF

Rogers, NL, Dinges, DF. Subjective surrogates of performance during night work. Sleep 26: 790-791, 2003. PMID:14655909

Rogers, NL, Dinges, DF, Kennaway, DJ, Dawson, D. Potential action of melatonin in insomnia. Sleep 26: 1058-1059, 2003. PMID:14746391

Rogers, NL, Dorrian, J, Dinges, DF. Sleep, waking and neurobehavioral performance. Frontiers in Bioscience 8: s1056-s1067, 2003. PMID:12957855

Van Dongen, HPA, Dinges, DF.Investigating the interaction between the homeostatic and circadian processes of sleep-wake regulation for the prediction of waking neurobehavioural performance. Journal of Sleep Research 12: 181-187, 2003.Click Here to View PDF

Van Dongen, HPA, Dinges, DF.Sleep debt and cumulative excess wakefulness. Sleep 26: 249, 2003.Click Here to View PDF

Van Dongen, HPA, Maislin, G, Mullington, JM, Dinges, DF.The cumulative cost of additional wakefulness: Dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation. Sleep 26: 117-126, 2003.Click Here to View PDF

Van Dongen, HPA, Rogers, NL, Dinges, DF.Sleep debt: Theoretical and empirical issues. Sleep and Biological Rhythms 1: 5-13, 2003.Click Here to View PDF

Weaver, TE, Maislin, G, Dinges, DF, Younger, J, Cantor, C, McCloskey, S, Pack, AI.Self-efficacy in sleep apnea: Instrumental development and patient perceptions of obstructive sleep apnea risk, treatment benefit, and volition to use continuous positive airway pressure. Sleep 26: 727-732, 2003.Click Here to View PDF

Doran, SM, Van Dongen, HPA, Dinges, DF.Sustained attention performance during sleep deprivation: Evidence of state instability. Archives of Italian Biology 139: 253-267, 2001.Click Here to View PDF

Rogers, NL, Dinges, DF. Shiftwork, circadian disruption and consequences. The Economics of Neuroscience 6: 58-64, 2001.

Rogers, NL Szuba, MP, Staab, JP, Evans, DL, Dinges, DF. Neuroimmunologic aspects of sleep and sleep loss. Seminars in Clinical Neuropsychiatry 6: 295-307, 2001. PMID:11607924

Van Dongen, HPA, Dinges, DF.Modeling the effects of sleep debt: On the relevance of inter-individual differences. Sleep Research Society Bulletin 7: 69-72, 2001.Click Here to View PDF

Van Dongen, HPA, Maislin, G, Kerkhof, GA.Repeated assessment of the endogenous 24-hour profile of blood pressure under constant routine. Chronobiology International 18: 85-98, 2001.Click Here to View PDF

Van Dongen, HPA, Price, NJ, Mullington, JM, Szuba, MP, Kapoor, SC, Dinges, DF.Caffeine eliminates psychomotor vigilance deficits from sleep inertia. Sleep 24: 813-819, 2001.Click Here to View PDF