Department of Psychiatry
Penn Behavioral Health

Unit for Experimental Psychiatry Division of Sleep and Chronobiology

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Selected Publications

Basner, M., Dinges, D.F. Maximizing sensitivity of the Psychomotor Vigilance Test (PVT) to sleep loss. SLEEP (in press).

Minkel, J.D., Htaik, O., Banks, S., Dinges, D.F. A night of sleep deprivation reduces the intensity of emotional expressions in healthy adults. Behavioral Sleep Medicine, 9:5-14, 2011.

Simpson, N.S., Banks, S., Arroyo, S., Dinges, D.F. Effects of sleep restriction on adiponectin levels in healthy men and women. Physiology and Behavior 101:693-698, 2010.

Goel, N., Banks, S., Mignot, E., Dinges, D.F. DQB1*0602 Predicts interindividual differences in physiological sleep, sleepiness and fatigue. Neurology 75:1509-1519, 2010.

Banks, S., Van Dongen, H.P.A., Maislin, G., Dinges, D.F. Neurobehavioral dynamics following chronic sleep restriction: Dose-response effects of one night for recovery. SLEEP 33(8):1013-1026, 2010.

Mollicone, D.J., Van Dongen, H., Rogers, N.L., Banks, S., Dinges, D.F.: Time of day modulates the effects of chronic sleep restriction on neurobehavioral performance. Aviation, Space & Environmental Medicine, 81: 735-744, August, 2010.

Lim, J., Wu, W-C, Wang, J., Detre, J.A., Dinges, D.F., Rao, H. Imaging brain fatigue from sustained mental workload: An ASL perfusion study of the time-on-task effect, NeuroImage, 49(4): 3426-3435, 2010. 

Lim, J., Tan, J.C., Parimal, S., Dinges, D.F., Chee, M.W.L. Sleep deprivation impairs object-selective attention: A view from the ventral visual cortex. PLoS ONE www.plosone.org, February 5, 2010.

Goel, N. Rao, H., Durmer, J., Dinges, D.F.: Neurocognitive consequences of sleep deprivation. Seminars in Neurology, 29(4): 320-339, 2009.

Gunzelmann, G., Gross, J.B., Gluck, K.A., Dinges, D.F. Sleep deprivation and sustained attention performance: Integrating mathematical and cognitive modeling. Cognitive Science, 33(5), 880-910, 2009.

Goel, N., Banks, S., Mignot, E., Dinges, D.F.: PER3 polymorphism predicts cumulative sleep homeostatic but not neurobehavioral changes to chronic partial sleep deprivation. PLoS ONE www.plosone.org 4(6):e5874, June 2009.

Goel, N., Stunkard, A.J., Rogers, N.L., Van Dongen, H.P.A., Allison, K.C., O’Reardon, J.P., Ahima, R.S., Cummings, D.E., Moonseong Heo, Dinges, D.F.: Circadian rhythm profiles in women with Night Eating Syndrome. Journal of Biological Rhythms 24(1):85-94, 2009.

McCauley, P, Kalachev, L.V., Smith, A.D., Belenky, G., Dinges, D.F., Van Dongen, H.: A new mathematical model for the homeostatic effects of sleep loss on neurobehavioral performance. Journal of Theoretical Biology 256:227–239, 2009.

Gunzelmann, G., Gross, J.B., Gluck, K.A., Dinges, D.F. Sleep deprivation and sustained attention performance: Integrating mathematical and cognitive modeling. Cognitive Science, 33(5), 880-910, 2009.

Gunzelmann, G., Moore, L. R., Gluck, K. A., Van Dongen, H. P. A., Dinges, D.F., Individual differences in sustained vigilant attention: Insights from computational cognitive modeling. In B.C. Love, K. McRae, V. M. Sloutsky (Eds.), Proceedings of the Thirtieth Annual Meeting of the Cognitive Science Society, Austin, TX: Cognitive Science Society, 2017-2022, 2008.

Mollicone, D.J., Van Dongen, H.P.A., Rogers, N.L., Dinges, DF. Response surface mapping of neurobehavioral performance: testing the feasibility of split sleep schedules for space operations. Acta Astronautica 63(7-10): 833-840, 2008.

Basner, M., Rubinstein, J., Fomberstein, K.M., Coble, M.C., Ecker, A., Avinash, D., Dinges, D.F., Effects of night work, sleep loss and time on task on simulated threat detection performance. Sleep, 31(9):1251-1259, 2008.

Chee MLW, Tan CH, Hui Z, Parimal S, Weissman SD, Zagorodnov V, Dinges DF. Lapsing during sleep deprivation is associated with distributed changes in brain activation. J Neurosci, 28(21):5519-5528, May 21, 2008.Click Here to View PDF

Lim J, Dinges DF. Sleep deprivation and vigilant attention. Annals N Y Acad Sci, 1129:305-322, 2008.Click Here to View PDF

Simpson, N., Dinges, D.F.: Sleep and inflammation. Nutrition Reviews. II: S244–S252, December 2007.

Scott, L.D., Hwang, W.-T., Rogers , A.E., Nysse, T., Dean, G.E., Dinges, D.F.: The relationship between nurse work schedules, sleep duration, and drowsy driving. Sleep, 30(12):1801-1807, 2007.

Kim , H., Dinges, D.F., Young , T.: Sleep-disordered breathing and psychomotor vigilance in a community-based sample. Sleep, 30(10):1309-1316, 2007.

Tucker, A.M., Dinges, D.F., Van Dongen, H.P.A.: Trait inter-individual differences in the sleep physiology of healthy young adults. Journal of Sleep Research, 16:1-11, 2007.

Banks, S., Dinges, D.F.: Behavioral and physiological consequences of sleep restriction in humans. Journal of Clinical Sleep Medicine 3(5):519-528, 2007.

Van Dongen, H.P.A., Mott, C.G., Huang, J-K, Mollicone, D.J., McKenzie, F.D., Dinges, D.F : Optimization of biomathematical model predictions for cognitive performance impairment in individuals: accounting for unknown traits and uncertain states in homeostatic and circadian processes running head: performance prediction in individuals . Sleep 30(9): 1125-1139, 2007.

Basner, M., Fomberstein, K., Razavi, F.M., William, J., Simpson, N., Rosa, R., Dinges, D.F : American Time Use Survey: Sleep time and its relationship to waking activities. Sleep 30(9): 1081-1091, 2007.

Weaver, T.E., Maislin, G., Dinges, D.F., Bloxham, T., George, C., Greenberg, H., Kader, G., Mahowald, M., Younger, J., Pack, A.I.: Relationship between hours of CPAP use and achieving normal levels of sleepiness and daily functioning. Sleep, 30(6):711-719, 2007.

Mollicone, D.J., Van Dongen, H., Dinges, D.F.: Optimizing sleep/wake schedules in space: Sleep during chronic nocturnal sleep restriction with and without diurnal naps. Acta Astronautica, 60:354-361, 2007.

Dinges, D.F., Venkataraman, S., McGlinchey, E.L., Metaxas, D.N : Monitoring of facial stress during space flight: Optical computer recognition combining discriminative and generative methods . Acta Astronautica 60: 341-350, 2007.

Scott, L.D., Hwang, W.-T., Rogers, A.E., Nysse, T., Dean, G.E., Dinges, D.F : The relationship between nurse work schedules, sleep duration, and drowsy driving. Sleep 3(12): 1801 - 1807, 2007. Click Here to View PDF

Dinges, D.F., Arora, S., Darwish, M., Niebler, G.E : Pharmacodynamic effects on alertness of single doses of armodafinil in healthy subjects during a nocturnal period of acute sleep loss . Current Medical Research and Opinions 22(1): 159-167, 2006.

Chee, M.W.L., Chuah, L.Y.M., Venkatraman, V., Chan, W.Y., Philip, P., Dinges, D.F : Functional imaging of working memory following normal sleep and after 24 and 35 h of sleep deprivation: Correlations of fronto-parietal activation with performance. NeuroImage 31: 419-428, 2006. Click Here to View PDF

Chuah, Y.M.L., Venkatraman, V., Dinges, D.F., Chee, M.W.L : The neural basis of inter-individual variability in inhibitory efficiency following sleep deprivation. The Journal of Neuroscience 26(27): 7156-7162, 2006. Click Here to View PDF

Ellenbogen, J.M., Hulbert, J.C., Stickgold, R., Dinges, D.F., Thompson-Schill, S.L : Interfering with theories of sleep and memory: sleep, declarative memory, and associative interference. Current Biology 16: 1290-1294, 2006.

Pack, A.I., Maislin, G., Pack, F.M., George, C., Staley, B.,George, C.F.P, Rogers, W., Dinges, D.F. : Impaired performance in commercial drivers: Role of Sleep Apnea and sleep duration. American Journal of Respiratory and Critical Care Medicine 174: 446-454, 2006.

Pack, A.I., Maislin, G., Pack, F.M., George, C., Staley, B., Rogers, W., George, C.F.P., Dinges, D.F.:  Impaired performance in commercial drivers:  Role of sleep apnea and sleep duration. American Journal of Respiratory and Critical Care Medicine, 174:446-454, 2006.

Dinges, D.F.: Cocoa flavanols, cerebral blood flow, cognition, and health: Going forward. Journal of Cardiovascular Pharmacology, 47(2): S221-S223, 2006.

Chuah, Y.M.L., Venkatraman, V., Dinges, D.F., Chee, M.W.L.: The neural basis of inter-individual variability in inhibitory efficiency following sleep deprivation. The Journal of Neuroscience, 26(27):7156-7162, 2006.

Ellenbogen, J.M., Hulbert, J.C., Stickgold, R., Dinges, D.F., Thompson-Schill, S.L.: Interfering with theories of sleep and memory: sleep, declarative memory, and associative interference. Current Biology, 16:1290-1294, 2006.

Pack, A.I., Maislin, G., Pack, F.M., George, C., Staley, B., Rogers, W., George, C.F.P., Dinges, D.F.: Impaired performance in commercial drivers: Role of sleep apnea and sleep duration. American Journal of Respiratory and Critical Care Medicine, 174:446-454, 2006.

Dinges, D.F.: Cocoa flavanols, cerebral blood flow, cognition, and health: Going forward. Journal of Cardiovascular Pharmacology, 47(2): S221-S223, 2006.

Chuah, Y.M.L., Venkatraman, V., Dinges, D.F., Chee, M.W.L.: The neural basis of inter-individual variability in inhibitory efficiency following sleep deprivation. The Journal of Neuroscience, 26(27):7156-7162, 2006.

Ellenbogen, J.M., Hulbert, J.C., Stickgold, R., Dinges, D.F., Thompson-Schill, S.L.: Interfering with theories of sleep and memory: sleep, declarative memory, and associative interference. Current Biology, 16:1290-1294, 2006.

Pack, A.I., Dinges, D.F, Gehrman, P.R., Staley, B., Pack, F.M., Maislin, G.: Risk factors for excessive sleepiness in older adults. Annals of Neurology, 59:893-904, 2006.

Dinges, D.F., Arora, S., Darwish, M., Niebler, G.E.: Pharmacodynamic effects on alertness of single doses of armodafinil in healthy subjects during a nocturnal period of acute sleep loss. Current Medical Research and Opinions, 22(1): 159-167, 2006.

Chee, M.W.L., Chuah, L.Y.M., Venkatraman, V., Chan, W.Y., Philip, P., Dinges, D.F.: Functional imaging of working memory following normal sleep and after 24 and 35 h of sleep deprivation: Correlations of fronto-parietal activation with performance. NeuroImage, 31: 419-428, 2006.

Rogers, N.L., Dinges, D.F., Maislin, G., Allison, K.C., Martino, N.S., O'Reardon, J.P., Stunkard, A.J.: Assessment of sleep in women with night eating syndrome. Sleep, 29(6), 814-819, 2006.

Allison, K.C., Ahima, R., O'Reardon, J.P., Dinges, D.F., Sharma, V., Cummings, D.E., Heo, M., Martino, N.S., Stunkard, A.J.: Neuroendocrine profiles associated with energy intake, sleep and stress in the night eating syndrome. Journal of Clinical Endocrinology and Metabolism 90 (11): 6214-6217, 2005.

Avinash, D., Crudele, C.P., Amin, D., Robinson, B.M., Dinges, D.F., Van Dongen, H.P.: Parameter estimation for a biomathematical model of psychomotor vigilance performance under laboratory conditions of chronic sleep restriction. Sleep-Wake Research in The Netherlands 16: 39-42, 2005.

Czeisler, C.A., Walsh, J.K., Roth, T., Hughes, R.J., Wright, K.P., Kingsbury, L., Arora, S., Schwartz, J.R.L., Niebler, G., Dinges, D.F.: Modafinil for excessive sleepiness associated with shift work sleep disorder. New England Journal of Medicine, 353:476-486, 2005.

Dinges, D.F., Maislin, G. Brewster, R.M., Krueger, G.P., Carroll, R.J.:Click Here to View PDF Pilot test of fatigue management technologies. Journal of the Transportation Research Board No. 1922, Transportation Research Board of the National Academies, Washington, DC, 175-182, 2005.

Dinges, D.F., Rider, R.L., Dorrian, J., McGlinchey, E.L., Rogers, N.L., Cizman, Z., Goldenstein, S.K., Vogler, C., Venkataraman, S., Metaxas, D.N.: Optical computer recognition of facial expressions associated with stress induced by performance demands. Aviation, Space & Environmental Medicine 76(6): B172-182, 2005.

Dorrian J, Rogers NL, Dinges DF. Psychomotor vigilance performance: A neurocognitive assay sensitive to sleep loss. In: Kushida C (Ed), Sleep Deprivation: Clinical Issues, Pharmacology and Sleep Loss Effects. Marcel Dekker, Inc., NY, pp. 39-70, 2005. Click Here to View PDF

Drummond, S.P.A., Bischoff-Grethe, A., Dinges, D.F., Ayalon, L., Mednick, S.C., Meloy, M.J.: The neural basis of the psychomotor vigilance task. Sleep 28(9):1059-1068, 2005.Click Here to View PDF

Durmer, J.S. and Dinges, D.F.: Click Here to View PDF Neurocognitive consequences of sleep deprivation. Seminars in Neurology, 25(1): 117-129, 2005.

Hoffman, J.M., Van Dongen, H.P.A., Dinges, D.F.: Time of day and sleep inertia effects on cognitive performance and sleepiness during chronic sleep restriction. Sleep-Wake Research in The Netherlands, 16: 75-78, 2005.

Rogers, N.L., Dinges, D.F.: Caffeine: Implications for alertness in athletes. Journal for Clinics in Sports Medicine 24:1-13, 2005.

Van Dongen, H.P.A., Dinges, D.F.: Sleep, circadian rhythms, and psychomotor vigilance performance. Journal for Clinics in Sports Medicine 24:237-249, 2005.

Whitehouse, W.G., Orne, E.C., Dinges, D.F., Bates, B.L., Nadon, R., Orne, M.T.: The cognitive interview: Does it successfully avoid the dangers of forensic hypnosis? American Journal of Psychology 118(2): 215-234, 2005.

Wang, J., Wetmore, G.S., Rao, H., Furlan, P.M., Korczykowski, M.. Dinges, D.F., Detre, J.A.: The stressed brain - perfusion fMRI reveals cerebral blood flow pattern under psychological stress. Proceedings of the National Academy of Sciences 102(49): 17804-17809, 2005.

Mallis, MM, Mejdal, S, Nguyen, TT, Dinges, DF. Summary of the key features of seven biomathematical models of human fatigue and performance. Aviation, Space, and Environmental Medicine 75 Section II: A4-A14, 2004.Summary of the key features of seven biomathematical models of human fatigue and performance. Aviation, Space, and Environmental Medicine 75: A4-A14, 2004.

Meier-Ewert, HK, Ridker, PM, Rifai, N, Regan, MM, Price, NJ, Dinges, DF, Mullington, JM. Click Here to View PDF Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. Journal of the American College of Cardiology 43: 678-683, 2004.

Olofsen, E, Dinges, DF, Van Dongen, HPA. Click Here to View PDF Non-linear mixed effects modeling: Individualization and prediction. Aviation, Space, and Environmental Medicine 75: A134-A140, 2004.

Van Dongen HPA. Click Here to View PDF Comparison of mathematical model predictions to experimental data of fatigue and performance. Aviation, Space, and Environmental Medicine 75: A15-A36, 2004.

Van Dongen, HPA, Baynard, MD, Maislin, G, Dinges, DF. Click Here to View PDF Systematic interindividual differences in neurobehavioral impairment from sleep loss: Evidence of trait-like differential vulnerability. Sleep 27: 423-433, 2004.

Van Dongen, HPA, Maislin, G, Dinges, DF. Click Here to View PDF Dealing with inter-individual differences in the temporal dynamics of fatigue and performance: Importance and techniques. Aviation, Space, and Environmental Medicine 75: A147-A154, 2004.

Dinges, DF, Weaver, TE. Effects of modafinil on sustained attention performance and quality of life in OSA patients with residual sleepiness while being treated with nCPAP. Sleep Medicine 4: 393-402, 2003.

Mullington, JM, Chan, JL, Van Dongen, HPA, Szuba, MP, Samaras, J, Price, NJ, Meier-Ewert, HK, Dinges, DF, Mantzoros, CS. Click Here to View PDF Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men. Journal of Neuroendocrinology 15: 851-854, 2003.

Rogers, NL, Dinges, DF. Subjective surrogates of performance during night work. Sleep 26: 790-791, 2003.

Rogers, NL, Dinges, DF, Kennaway, DJ, Dawson, D. Potential action of melatonin in insomnia. Sleep 26: 1058-1059, 2003.

Rogers, NL, Dorrian, J, Dinges, DF. Sleep, waking and neurobehavioral performance. Frontiers in Bioscience 8: s1056-s1067, 2003.

Van Dongen, HPA, Dinges, DF. Click Here to View PDF Investigating the interaction between the homeostatic and circadian processes of sleep-wake regulation for the prediction of waking neurobehavioural performance. Journal of Sleep Research 12: 181-187, 2003.

Van Dongen, HPA, Dinges, DF. Click Here to View PDF Sleep debt and cumulative excess wakefulness. Sleep 26: 249, 2003.

Van Dongen, HPA, Maislin, G, Mullington, JM, Dinges, DF. Click Here to View PDF The cumulative cost of additional wakefulness: Dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation. Sleep 26: 117-126, 2003.

Van Dongen, HPA, Rogers, NL, Dinges, DF. Click Here to View PDF Sleep debt: Theoretical and empirical issues. Sleep and Biological Rhythms 1: 5-13, 2003.

Weaver, TE, Maislin, G, Dinges, DF, Younger, J, Cantor, C, McCloskey, S, Pack, AI. Click Here to View PDF Self-efficacy in sleep apnea: Instrumental development and patient perceptions of obstructive sleep apnea risk, treatment benefit, and volition to use continuous positive airway pressure. Sleep 26: 727-732, 2003.

Doran, SM, Van Dongen, HPA, Dinges, DF. Click Here to View PDF Sustained attention performance during sleep deprivation: Evidence of state instability. Archives of Italian Biology 139: 253-267, 2001.

Rogers, NL, Dinges, DF. Shiftwork, circadian disruption and consequences. The Economics of Neuroscience 6: 58-64, 2001.

Rogers, NL Szuba, MP, Staab, JP, Evans, DL, Dinges, DF. Sleep, sleep loss and immune function in humans. Seminars in Clinical Neuropsychiatry 6: 295-307, 2001.

Van Dongen, HPA, Dinges, DF. Click Here to View PDF Modeling the effects of sleep debt: On the relevance of inter-individual differences. Sleep Research Society Bulletin 7: 69-72, 2001.

Van Dongen, HPA, Maislin, G, Kerkhof, GA.Click Here to View PDF Repeated assessment of the endogenous 24-hour profile of blood pressure under constant routine. Chronobiology International 18: 85-98, 2001.

Van Dongen, HPA, Price, NJ, Mullington, JM, Szuba, MP, Kapoor, SC, Dinges, DF. Click Here to View PDF Caffeine eliminates psychomotor vigilance deficits from sleep inertia. Sleep 24: 813-819, 2001.