Josh Wand

Josh Wand was born and raised in Ottawa, Canada. He received his B.Sc. (Hons) in biochemistry from Carleton University in Ottawa.

Working under the direction of Stan Tsai, he also received a M.Sc. in bioorganic chemistry from Carleton University. He received his Ph.D. in biophysics from the University of Pennsylvania under the guidance of Walter Englander.

After a short postdoctoral stint in solid state NMR at the National Research Council of Canada with I.C.P. Smith, he joined the faculty of the Institute for Cancer Research. He subsequently spent time on the faculties of the University of Illinois at Urbana-Champaign and the State University of New York at Buffalo.

He is currently the Benjamin Rush Professor of Biochemistry & Biophysics where he continues to employ novel applications of solution NMR to questions in protein biophysics.

Welcome to the Wand Lab. Our research group focuses on novel applications of high resolution solution and solid state NMR techniques to fundamental problems in biophysics. Our interest in protein biophysics include the on-going development of reverse micelle encapsulation to study the structure & dynamics of large soluble proteins, integral and anchored membrane proteins and their complexes; the use of advanced NMR relaxation techniques to characterize the internal dynamics of proteins and employ the "dynamical proxy" as an "entropy meter" to explore the role of conformational entropy in the energetics of protein-ligand interactions; to develop and use hydrogen-exchange based methods to journey over the protein energy landscape in a variety of contexts; to understand the role of solvent in maintaining the structural and dynamic integrity of proteins; applications of protein design and engineering in a variety of contexts.

We are also have a number of NMR methods development efforts. These include sensitivity optimized sparse NMR data acquisition, high pressure NMR apparatus, applications and computer-assisted NMR data analysis and the development of a novel strategy for dynamic nuclear polarization in liquids based on our reverse micelle encapsulation technique.

Office Suite  
905 Stellar-Chance Labs
Department of Biochemistry & Biophysics
University of Pennsylvania
Perelman School of Medicine
422 Curie Blvd.
Philadelphia, PA 19104-6059
F: 215-573-7290
Professor Josh Wand
wand@pennmedicine.upenn.edu
T: 215-573-7288
Molecular Biology Lab  
904 Stellar-Chance Labs
Department of Biochemistry & Biophysics
University of Pennsylvania
Perelman School of Medicine
422 Curie Blvd.
Philadelphia, PA 19104-6059
T: 215-573-7289
Ms. Li Liang
lliang@pennmedicine.upenn.edu
NMR Lab  
G6 Blockley Hall
Department of Biochemistry & Biophysics
University of Pennsylvania
Perelman School of Medicine
423 Curie Blvd.
Philadelphia, PA 19104-6059
T: 215-573-5969
Dr. Kathy Valentine
valen@pennmedicine.upenn.edu
T: 215-573-5971

 

 

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Highlights

Seventh Graders at the Annual Spark Penn Med Science Show!

The Wand lab once again hosted seventh grade students from the Henry C. Lea Elementary School in West Philadelphia. Thanks to Alfredo Caro, Sravya Kotaru and Shannen Cravens for taking the lead and students from the SBMB training program for helping out! We thank Jordan Groutman of the Spark program for catalyzing this event.

Neo is here!

Josh accepts delivery of the Bruker NEO 800 NMR spectrometer. The instrument is joint purchase with Rowan University, Janssen Pharmaceuticals and the Department of Biochemistry & Biophysics. The instrument will be housed in the Department of Chemistry ground floor NMR space.

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