Josh Wand

Josh Wand was born and raised in Ottawa, Canada. He received his B.Sc. (Hons) in biochemistry from Carleton University in Ottawa.

Working under the direction of Stan Tsai, he also received a M.Sc. in bioorganic chemistry from Carleton University. He received his Ph.D. in biophysics from the University of Pennsylvania under the guidance of Walter Englander.

After a short postdoctoral stint in solid state NMR at the National Research Council of Canada with I.C.P. Smith, he joined the faculty of the Institute for Cancer Research. He subsequently spent time on the faculties of the University of Illinois at Urbana-Champaign and the State University of New York at Buffalo.

He is currently the Benjamin Rush Professor of Biochemistry & Biophysics where he continues to employ novel applications of solution NMR to questions in protein biophysics.

Welcome to the Wand Lab. Our research group focuses on novel applications of high resolution solution and solid state NMR techniques to fundamental problems in biophysics. Our interest in protein biophysics include the on-going development of reverse micelle encapsulation to study the structure & dynamics of large soluble proteins, integral and anchored membrane proteins and their complexes; the use of advanced NMR relaxation techniques to characterize the internal dynamics of proteins and employ the "dynamical proxy" as an "entropy meter" to explore the role of conformational entropy in the energetics of protein-ligand interactions; to develop and use hydrogen-exchange based methods to journey over the protein energy landscape in a variety of contexts; to understand the role of solvent in maintaining the structural and dynamic integrity of proteins; applications of protein design and engineering in a variety of contexts.

We are also active in the development of sensitivity optimized sparse NMR data acquisition, high pressure NMR apparatus and applications and computer-assisted NMR data analysis.

Office Suite  
905 Stellar-Chance Labs
Department of Biochemistry & Biophysics
University of Pennsylvania
Perelman School of Medicine
422 Curie Blvd.
Philadelphia, PA 19104-6059
F: 215-573-7290
Professor Josh Wand
wand@mail.med.upenn.edu
T: 215-573-7288
Molecular Biology Lab  
904 Stellar-Chance Labs
Department of Biochemistry & Biophysics
University of Pennsylvania
Perelman School of Medicine
422 Curie Blvd.
Philadelphia, PA 19104-6059
T: 215-573-7289
Dr. Sabrina Bedard
sabrina.bedard@gmail.com
NMR Lab  
G6 Blockley Hall
Department of Biochemistry & Biophysics
University of Pennsylvania
Perelman School of Medicine
423 Curie Blvd.
Philadelphia, PA 19104-6059
T: 215-573-5969
Dr. Kathy Valentine
valen@mail.med.upenn.edu
T: 215-573-5971

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Wand Lab at Snowbird

Some Wandites at Snowbird, UT

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