Wangensteen Lab

  • Image of liver staining for FAH

    Liver staining for FAH

  • Philadelphia Skyline
  • Immunofluorescence staining

    Immunofluorescence staining showing repopulating hepatocytes (Green label), pericentral hepatocytes (Red), and overlap (Yellow)

Welcome to the Wangensteen Lab

 

Our lab is conducting exciting research on the genetics of liver repopulation and hepatocellular carcinoma (HCC). We have developed two highly innovative in vivo genetic screening paradigms to elucidate genetic pathways involved in carcinogenesis and liver repopulation in the setting of toxic injury. We aim to discover pathways that lead to drug sensitivity and resistance in HCC.  One of our assays involves CRISPR activation screening in vivo in the liver, the first-ever use of this type of screening in live mice.


image depicting in vivo screening approach

 

Welcome new lab members!

Congratulations Kirk Wangensteen on being awarded the McCabe Fund Pilot Award!


The Wangensteen Lab welcomed new members in May and June:

Jie Chen, MD

Morgan Preziosi, PhD

Sofi Vergara, undergraduate student

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