Limb-girdle muscular dystrophy Type 2B and Miyoshi myopathy both result from loss of expression of the protein known as dysferlin. The designation as two different diseases is historical, based on different early clinical presentations (proximal muscles in LGMD2B and distal muscles in Miyoshi). Since one copy of dysferlin is sufficient, the disease displays recessive inheritance. The function of the dysferlin protein is not totally understood. It is a member of the ferlin family of proteins and thus functions to mediate calcium-activated vesicle fusion. It is widely thought to be critical for muscle membrane repair.