White Lab

Publications

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Since 2017:

Hatterschide J, Castagnino P, Kim HW, Sperry SM, Montone KT, Basu D, White EA. YAP1 activation by human papillomavirus E7 promotes basal cell identity in squamous epithelia. eLife. 11:e75466. February 2022. 

Carey RM, McMahon DB, Miller ZA, Kim T, Rajasekaran K, Gopallawa I, Newman JG, Basu D, Nead KT, White EA, Lee RJ. T2R bitter taste receptors regulate apoptosis and may be associated with survival in head and neck squamous cell carcinoma. Molecular Oncology. 16(7):1474-1492. December 2021.

Facompre ND, Rajagopalan P, Sahu V, Pearson AT, Montone KT, James CD, Gleber‐Netto FO, Weinstein GS, Jalaly J, Lin A, Rustgi AK, Nakagawa H, Califano JA, Pickering CR, White EA, Windle B, Morgan IM, Cohen RB, Gimotty PA, Basu D: Identifying predictors of HPV‐related head and neck squamous cell carcinoma progression and survival through patient‐derived models. Int. J. Cancer. 147(11):3236-3249. December 2020.

Hatterschide J, Brantly AC, Grace M, Munger K, White EA: A conserved amino acid in the C-terminus of HPV E7 mediates binding to PTPN14 and repression of epithelial differentiation. Journal of Virology. 94(17):e01024-20. August 2020.

White EA: Manipulation of Epithelial Differentiation by HPV Oncoproteins. Viruses. 11(4):E369. Invited review for Tenth Anniversary Issue. April 2019.

Hatterschide J, Bohidar AE, Grace M, Nulton TJ, Kim HW, Windle B, Morgan IM, Munger K, White EA: PTPN14 degradation by high-risk human papillomavirus E7 limits keratinocyte differentiation and contributes to HPV-mediated oncogenesis. Proc Natl Acad Sci USA. 116(14):7033-7042. April 2019.

White EA, Shanmugasundaram S, You J.  Manipulation of the host immune response by small DNA tumor viruses.  In: Microbiome and Cancer. 
Humana Press. pp 261-297. 2019.

Evans MR, James CD, Bristol ML, Nulton TJ, Wang X, Kaur N, White EA, Windle B, Morgan IM: Human Papillomavirus 16 E2 Regulates Keratinocyte Gene Expression Relevant to Cancer and the Viral Life Cycle. Journal of Virology. 93(4) pii: e01941-18. February 2019.

Bentley P, Tan MJA, McBride AA, White EA*, Howley PM*: The SMC5/6 complex interacts with the papillomavirus E2 protein and influences maintenance of viral episomal DNA. *co-corresponding authors Journal of Virology. 92(15): e00356-18. August 2018.

Chiang C, Pauli EK, Biryukov J, Feister KF, Meng M, White EA, Münger K, Howley PM, Meyers C, Gack MU: The Human Papillomavirus E6 Oncoprotein Targets USP15 and TRIM25 to Suppress RIG-I-Mediated Innate Immune Signaling. Journal of Virology.  92(6) pii: e01737-17.  March 2018.

Cheng J, Park DE, Berrios C, White EA, Arora R, Yoon R, Branigan T, Xiao T, Westerling T, Federation A, Zeid R, Strober B, Swanson SK, Florens L, Bradner JE, Brown M, Howley PM, Padi M, Washburn MP, DeCaprio JA.  Merkel Cell Polyomavirus Recruits MYCL to the EP400 Complex to Promote Oncogenesis.  PLoS Pathogens. 13(10):e1006668.  October 2017.

White EA, Munger K.  Crowd Control: E7 is the Key to Cancer.  Cell 170(6):1057-1059.  September 2017.

Selected from pre-2016:

White EA, Münger K, Howley PM: High-Risk Human Papillomavirus E7 Proteins Target PTPN14 for Degradation. mBio 7(5): 5, Sep 2016.

Rouleau C, Pores Fernando AT, Hwang JH, Faure N, Jiang T, White EA, Roberts TM, Schaffhausen BS: Transformation by Polyomavirus Middle T Antigen Involves a Unique Bimodal Interaction with the Hippo Effector YAP. J Virol 90(16): 16, Jul 2016.

White EA, Kramer RE, Hwang JH, Pores Fernando AT, Naetar N, Hahn WC, Roberts TM, Schaffhausen BS, Livingston DM, Howley PM: Papillomavirus E7 oncoproteins share functions with polyomavirus small T antigens. J Virol 89(5): 2857-65, Mar 2015.

Vieira VC, Leonard B, White EA, Starrett GJ, Temiz NA, Lorenz LD, Lee D, Soares MA, Lambert PF, Howley PM, Harris RS: Human papillomavirus E6 triggers upregulation of the antiviral and cancer genomic DNA deaminase APOBEC3B. mBio 5(6): 2045, Dec 2014.

Smith JA, Haberstroh FS, White EA, Livingston DM, DeCaprio JA, Howley PM: SMCX and components of the TIP60 complex contribute to E2 regulation of the HPV E6/E7 promoter. Virology 468-470: 311-21, Nov 2014.

White EA, Walther J, Javanbakht H, Howley PM: Genus beta human papillomavirus E6 proteins vary in their effects on the transactivation of p53 target genes. J Virol 88(15): 8201-12, Aug 2014.

White EA, Kramer RE, Tan MJ, Hayes SD, Harper JW, Howley PM: Comprehensive analysis of host cellular interactions with human papillomavirus E6 proteins identifies new E6 binding partners and reflects viral diversity. J Virol 86(24): 13174-86, Dec 2012.

Tan MJ, White EA, Sowa ME, Harper JW, Aster JC, Howley PM: Cutaneous β-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling. Proc Natl Acad Sci USA 109(23): E1473-80, Jun 2012.

White EA, Sowa ME, Tan MJ, Jeudy S, Hayes SD, Santha S, Münger K, Harper JW, Howley PM: Systematic identification of interactions between host cell proteins and E7 oncoproteins from diverse human papillomaviruses. Proc Natl Acad Sci USA 109(5): E260-7, Jan 2012.

Smith JA, White EA, Sowa ME, Powell ML, Ottinger M, Harper JW, Howley PM: Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression. Proc Natl Acad Sci USA 107(8): 3752-7, Feb 2010.