Perelman School of Medicine at the University of Pennsylvania

Yang Lab

  • banner image
  • banner image

Welcome to the Yang Lab

The Yang Lab is in the Department of Cancer Biology, in the Perelman School of Medicine.

Our research is aimed at understanding the mechanisms of tumor suppression. A longstanding research objective is to understand the molecular mechanisms of apoptosis. We focus on the central executioners of apoptosis, caspases, and their regulatory proteins. In recent years, we have also extended our study to the tumor suppressor p53, which induces apoptosis and other anti-proliferative processes in response to tumor-promoting stresses. Furthermore, the lab is investigating the mechanism of the promyelocytic leukemia protein nuclear bodies (PML-NBs). These proteinaceous organelles have a prominent role in tumor suppression and are also involved in other cellular processes including defense against viral infection and neurodegeneration