Selected Publications

  • Zhang Z.-Y., Harischandra D.S., Wang R., Ghaisas S., Zhao J.Y., McMonagle T.P., Zhu G., Lacuarta K.D., Song J., Trojanowski J.Q., Xu H., Lee V. M.-Y., Yang X.: TRIM11 protects against tauopathies and is down-regulated in Alzheimer's disease Science381: eadd6696, 2023 Notes: Comment in Science 381: 377-378, 2023.
  • Zhang Y., Xu Y., Lu W., Li J., Yu S., Brown E.J., Stanger B.Z., Rabinowitz J.D., Yang X.: G6PD-mediated increase in de novo NADP+ biosynthesis promotes antioxidant defense and tumor metastasis. Science Advances 8: eabo0404, 2022.
  • Zhu, G., Herlyn M., and Yang X.: TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination. Nature Cell Biology 23: 978-991, 2021.
  • Zhang Y., Xu Y., Lu W., Ghergurovich J.M., Guo L., Blair I.A., Rabinowitz J.D., and Yang X.: Upregulation of antioxidant capacity and nucleotide precursor availability suffices for oncogenic transformation. Cell Metabolism 33: 94-109, 2021.
  • Huang L., Agrawal T., Zhu G., Yu S., Tao L., Lin J., Marmorstein R., Shorter J., Yang X.: DAXX represents a new type of protein-folding enabler. Nature 597: 132-137, 2021.
  • Zhu G., Harischandra D.S., Ghaisas S., Zhang P., Prall W., Huang L.,Maghames C., Guo L., Luna E., Mack K.L., Torrente M.P., Luk K.C., Shorter J., and Yang X.: TRIM11 Prevents and Reverses Protein Aggregation and Rescues a Mouse Model of Parkinson's Disease. Cell Reports 33: 108418, 2020.
  • Xu Y., Zhang Y., García-Cañaveras J.C., Guo L., Yu S., Blair I.A., Rabinowitz J.D., and Yang X.: Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells. Science 369: 397-403, 2020 Notes: Comment in Science 369: 373-374, 2020.
  • Chen L., Zhu G., Johns EM., Yang X.: TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14. Nature Communications 9: 1223, 2018.
  • Chen L., Brewer M., Guo L., Wang R., Jiang P., Yang X.: Enhanced Degradation of Misfolded Proteins Promotes Tumorigenesis. Cell Reports 18: 3143-3154, 2017.
  • Guo L., Giasson B.I., Glavis-Bloom A., Brewer M.D., Shorter J., Gitler A.D., and Yang X.: A cellular system that degrades misfolded proteins and protects against neurodegeneration. Molecular Cell 55: 15-30, 2014 Notes: Cover story and comment in Molecular Cell 55:1-3, 2014
  • Jiang P., Du W., Mancuso A., Wellen K. and Yang X.: Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature 493: 689-93, 2013.
  • Du W., Jiang P., Mancuso A., Stonestrom A., Brewer M.D., Minn A.J., Mak T.W., Wu M., and Yang X: TAp73 enhances the pentose phosphate pathway and supports cell proliferation. Nature Cell Biology 15: 991-1000, 2013 Notes: Cover story and comment in Nature Cell Biology 15:891-3, 2013.
  • Jiang P., Du W., Wang X., Mancuso A., Gao X., Wu M., and Yang X.: p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nature Cell Biology 13: 310-18, 2011 Notes: Cover story and comment in Nature Cell Biology 13:195-7, 2011.
  • Mei Y., Yong J., Liu H., Shi Y., Meinkoth J., Dreyfuss G., and Yang X.: tRNA binds to cytochrome c and inhibits caspase activation. Molecular Cell 37: 668-78, 2010 Notes: Cover story and comment in Molecular Cell 37: 591-2, 2010.
  • Kawadler H., Riley J.L., and Yang X.: The paracaspase MALT1 control caspase-8 activation during lymphocyte proliferation. Molecular Cell 31: 415-21, 2008.
  • Tang J., Qu L., Zhang J., Wang W., Michaelson J. S., Degenhardt Y., El-Deiry W.S., and Yang X.: Critical role for Daxx in regulating Mdm2. Nature Cell Biology 8: 855-62, 2006 Notes: Comment in Nature Cell Biology 8:790-1, 2006.
  • Hu S., Du M.-Q., Park S.-M., Alcivar A., Qu L., Gupta S., Tang J., Baens M., Ye H., Lee T., Marynen P., Riley J.L., and Yang X.: cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas. Journal of Clinical Investigation 116: 174-81, 2006 Notes: Comment in J Clin Invest. 116:22-6, 2006.