Selected Publications

Wang, I-T.J., Reyes, A.R., and Zhou. Z. . Neuronal morphology in MeCP2 mouse models is intrinsically variable and depends on age, cell type, and Mecp2 mutation. Neurobiology of Disease, doi: 10.1016/j.nbd.2013.04.020 [Epub ahead of print], 2013.

Goffin, D., Allen, M.*, Zhang, L.*, Amorim, M.*, Wang, I-T.J.*, Reyes, A.R., Mercado-Berton, A., Ong, C., Cohen, S., Hu, L., Blendy, J.A., Carlson, G., Siegel, S., Greenberg, M.E. and Zhou. Z. . Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses. Nature Neuroscience, 15:274-283, 2012.

Wang, I-T.J., Allen, M., Goffin, D., Zhu, X., Fairless, A.H., Brodkin, E.S., Siegel, S.J., Marsh, E.D., Blendy, J.A. and Zhou, Z.: Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice. Proc Natl Acad Sci USA, 109(52): 21516-21521, 2012.

Goffin, D. and Zhou, Z.: The neural circuit basis of Rett Syndrome. Frontiers in Biology, 7(5): 428-435, 2012.

Cohen, S., Gabel, H.W., Hamberg, M., Hutchinson, A.N., Sadacca, L.A., Ebert, D., Harmin, D.A., Greenberg, R.S., Verdine, V.K., Zhou, Z., Wetsel W.C., West, A.E. and Greenberg, M.E. . Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function. Neuron, 72:72-85, 2011.

Wood, L., Gray, N., Zhou, Z., Greenberg, M.E., Shepherd, G.M. : Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNAi model of MeCP2 deficiency. J. of Neuroscience 29: 12440-12448, 2009.

Bracaglia, G., Conca, B., Bergo, A., Rusconi, L., Zhou, Z., Greenberg, M., Landsberger, N. Soddu, S., Kilstrup-Nielsen C. : Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosis. EMBO 10: 1327 – 1333, 2009.

Cohen, S., Zhou, Z., and Greenberg, M.E.: Activating a repressor. Science 320: 1172-1173, 2008.

Cukier, H. N., Perez, A. M., Collins, A. L., Zhou, Z., Zoghbi, H. Y., Botas, J.: Genetic modifiers of MeCP2 function in Drosophila. PLoS Genet 4(9): e1000179, 2008.

Zhou, Z., Hong, E. J., Cohen, S., Zhao, W. N., Ho, H. Y., Schmidt, L., Chen, W. G., Lin, Y., Savner, E., Griffith, E. C., Hu, L., Steen, J. A., Weitz, C. J., Greenberg, M. E.: Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron 52(2): 255-69, 2006.

Zhou, Z., Licklider, L. J., Gygi, S. P., Reed, R.: Comprehensive proteomic analysis of the human spliceosome. Nature 419(6903): 182-5, 2002.

Zhou, Z., Sim, J., Griffith, J., Reed, R.: Purification and electron microscopic visualization of functional human spliceosomes. Proc Natl Acad Sci U S A 99(19): 12203-7, 2002.

Luo, M. L., Zhou, Z., Magni, K., Christoforides, C., Rappsilber, J., Mann, M., Reed, R.: Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly. Nature 413(6856): 644-7, 2001.

Das, R., Zhou, Z., Reed, R.: Functional association of U2 snRNP with the ATP-independent spliceosomal complex E. Mol Cell 5(5): 779-87, 2000.

Zhou, Z., Luo, M. J., Straesser, K., Katahira, J., Hurt, E., Reed, R.: The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans. Nature 407(6802): 401-5, 2000.

Zhou, Z. and Reed, R.: Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing. EMBO J. 17(7): 2095-2106, 1998.