The Zhou Lab University of Pennsylvania School of Medicine  

Selected Publications

Goffin D, Brodkin ES, Blendy JA, Siegel SJ and Zhou Z : Cellular origins of auditory event-related potential deficits in Rett syndrome. Nature Neuroscience, In Press, 2014.

Bissonnette JM#, Schaevitz LD, Knopp SJ and Zhou Z . Respiratory phenotypes are distinctly affected in mice with common Rett syndrome mutations MeCP2 T158A and R168X. Neuroscience, doi:10.1016/j.neuroscience 2014.02.043 [Epub ahead of print], 2014.

Zhao YT*, Goffin D*, Johnson SB* and Zhou Z . Loss of MeCP2 function is associated with distinct gene expression changes in the striatum. Neurobiology of Disease, 59C: 257-266, 2013.

Wang IT*, Reyes AR*, and Zhou Z . Neuronal morphology in MeCP2 mouse models is intrinsically variable and depends on age, cell type, and Mecp2 mutation. Neurobiology of Disease, 58C: 3-12, 2013.

Zhou Z and Goffin D . Modeling Rett Syndrome with MeCP2 T158A knockin mice. The Comprehensive Guide to Autism. Patel VB, Preedy VR and Martin C (eds), Springer Press, Chapter 181, 2013.

Goffin D, Allen M*, Zhang L*, Amorim M*, Wang IT*, Reyes AR, Mercado-Berton A, Ong C, Cohen S, Hu L, Blendy JA, Carlson G, Siegel S, Greenberg ME and Zhou Z . Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses. Nature Neuroscience, 15:274-283, 2012.

Wang IT, Allen M, Goffin D, Zhu X, Fairless AH, Brodkin ES, Siegel SJ, Marsh ED, Blendy JA and Zhou Z : Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice. Proc Natl Acad Sci USA, 109(52): 21516-21521, 2012.

Goffin D and Zhou Z : The neural circuit basis of Rett Syndrome. Frontiers in Biology, 7(5): 428-435, 2012.

Cohen S, Gabel HW, Hamberg M, Hutchinson AN, Sadacca LA, Ebert D, Harmin DA, Greenberg RS, Verdine VK, Zhou Z, Wetsel WC, West AE and Greenberg ME . Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function. Neuron, 72:72-85, 2011.

Wood L, Gray N, Zhou Z, Greenberg ME and Shepherd GM : Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNAi model of MeCP2 deficiency. J. of Neuroscience 29: 12440-12448, 2009.

Bracaglia G, Conca B, Bergo A, Rusconi L, Zhou Z, Greenberg M, Landsberger N, Soddu S, Kilstrup-Nielsen C : Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosis. EMBO Report 10: 1327-1333, 2009.

Cohen S, Zhou Z and Greenberg ME : Activating a repressor. Science 320: 1172-1173, 2008.

Cukier HN, Perez AM, Collins AL, Zhou Z, Zoghbi HY and Botas J : Genetic modifiers of MeCP2 function in Drosophila. PLoS Genet 4(9): e1000179, 2008.

Zhou Z, Hong EJ, Cohen S, Zhao WN, Ho HY, Schmidt L, Chen WG, Lin Y, Savner E, Griffith EC, Hu L, Steen JA, Weitz CJ and Greenberg ME : Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron 52(2): 255-269, 2006.

Zhou Z and Reed R : Purification of functional RNA-protein complexes using MS2-MBP. Current Protocols in Molecular Biology, Unit 27.3, 2003.

Zhou Z, Licklider LJ, Gygi SP and Reed R : Comprehensive proteomic analysis of the human spliceosome. Nature 419(6903): 182-185, 2002.

Zhou Z, Sim J, Griffith J and Reed R : Purification and electron microscopic visualization of functional human spliceosomes. Proc Natl Acad Sci USA 99(19): 12203-12207, 2002.

Luo ML, Zhou Z, Magni K, Christoforides C, Rappsilber J, Mann M and Reed R : Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly. Nature 413(6856): 644-7, 2001.

Clouse KN, Luo ML, Zhou Z and Reed R : A Ran-independent pathway for export of spliced mRNA . Nature Cell Biology 3(1): 97-99, 2001.

Das R, Zhou Z and Reed R : Functional association of U2 snRNP with the ATP-independent spliceosomal complex E. Mol Cell 5(5): 779-787, 2000.

Zhou Z, Luo MJ, Straesser K, Katahira J, Hurt E and Reed R : The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans. Nature 407(6802): 401-405, 2000.

Zhou Z and Reed R : Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing. EMBO J. 17(7): 2095-2106, 1998.