Researching bacterial pathogenesis

 

Amanda Hay
Graduate Student

Education:
University of Pennsylvania
Ph.D: Microbiology, 2016 (Expected)

Washington University in St. Louis
Bachelor of Arts: Biology & Biochemistry, 2011

Research Interests:
      
      Responses by bacteria to host compound during infection. Specifically investigating ways in which V. cholerae has co-opted host bile signals to coordinate several biological processes including biofilm residence and control of virulence gene regulation.


Publications:
Wang Y, Wang H, Hay AJ, Zhong Z, Zhu J, Kan B. (2015) Functional RelBE-Family Toxin-Antitoxin Pairs Affect Biofilm Maturation and Intestine Colonization in Vibrio cholerae. 
PLoS One. Aug 14;10(8)

Hay, AJ and Zhu, J. (2015) Host intestinal signal-promoted biofilm dispersal induces Vibrio Cholerae colonization. 
Infection and Immunity. Jan;83(1):317-23

Hay, AJ and Zhu, J. (2014) Microbiota Talks Cholera out of the Gut. 
Cell Host and Microbe Previews. Nov 12:16(1)

Leung, W, …Hay, AJ … Elgin, SCR (2015) "The Drosophila Muller F elements maintain a distinct set of genomic properties over 40 million years of evolution." 
G3: GENES, GENOMEs, GENETICS. Mar 4;5(5):719-40 [Total 940 student co-authors, 74 faculty co-authors.]

Stern AM, Hay AJ, Liu Z, Desland FA, Zhang J, Zhong Z, Zhu J. (2012) The NorR regulon is critical for Vibrio cholerae resistance to nitric oxide and sustained colonization of the intestines. 
MBio. Apr 17;3(2)

Wang, Y., Wang, H., Liang, W., Hay, A.J., Zhong, Z., Kan, B., and Zhu, J. (2013) Quorum sensing regulatory cascades control of Vibrio fluvialis pathogenesis. 
J Bacteriol. Aug;195(16):3583-9

Arur S, Ohmachi M, Nayak S, Hayes M, Miranda A, Hay AJ, Golden A, Schedl T. (2009) Multiple ERK Substrates Execute Single Biological Processes in Caenorhabditis elegans Germline Development. 
Proceedings of the National Academy of Sciences in the United States of America, v. 106, p.4776-4781.