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Sergei Vinogradov, PhD

Sergei Vinogradov

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Associate Professor of Biochemistry and Biophysics
Department: Biochemistry and Biophysics
Graduate Group Affiliations

Contact information
1013 Stellar-Chance Bldg.
422 Curie Blvd.
Department of Biochemistry and Biophysics
Philadelphia, PA 19104-6059
Office: 2155737524
Ph.D. (Organic Chemistry)
Moscow State University, 1995.
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Description of Research Expertise

Dr. Vinogradov's research revolves around functional molecular systems related to biological objects by function or application. We use methods of synthetic organic chemistry to design and construct molecules with predefined degree of active site encapsulation, photophysical properties and tunable energy and electron transfer pathways. Our special area of interest is construction of advanced probes for optical microscopy and imaging. We are developing methods for imaging of oxygen in biological tissues using phosphorescence quenching, including near infrared tomography by phosphorescence lifetime and two-photon microscopy of oxygen. These techniques are expected to provide useful tools for research in cancer, diabetes, ophthalmology and neuroscience. Two areas of chemistry are recurrent in our research: porphyrins and dendrimers. We study photophysics, acid/base properties and electrochemistry of aromatically pi-extended porphyrins, addressing various structure-property relationships in this porphyrin family.

Selected Publications

Esipova, T. V., Ye, X. C., Collins, J. E., Sakadzic, S., Mandeville, E. T., Murray, C. B., Vinogradov, S. A.: Dendritic upconverting nanoparticles enable in vivo multiphoton microscopy with low-power continuous wave sources. PNAS 109(51): 20826-20831, 2012.

Mani, T., Tanabe, M., Yamauchi, S., Tkachenko, N. V., Vinogradov, S. A.: Modulation of Visible Room Temperature Phosphorescence by Weak Magnetic Fields. Journal of Physical Chemistry Letters 3(21): 3115-3119, 2012.

Mani, T., Niedzwiedzki, D.M., Vinogradov, S.A.: Generation of Phosphorescent Triplet States via Photoinduced Electron Transfer: Energy and Electron Transfer Dynamics in Pt Porphyrin-Rhodamine B Dyads. J. Phys. Chem. A. 116: 3598−3610, 2012.

Vinogradov, S.A., Wilson, D.F. : Porphyrin-dendrimers as biological oxygen sensors. Designing dendrimers. Wiley, 2012.

Esipova, T. V., Karagodov, A., Miller, J., Wilson, D. F., Busch, T. M., Vinogradov, S. A.: Two new "protected" oxyphors for biological oximetry: properties and application in tumor imaging. Analytical Chemistry 83(22): 8756-8765, 2011.

Lecoq, J., Parpaleix, A., Roussakis, E., Ducros, M., Houssen, Y. G., Vinogradov, S. A.*, Charpak, S.*: Simultaneous two-photon imaging of oxygen and blood flow in deep cerebral vessels. Nature Medicine 17(7): 893-U262, 2011.

Sakadžić, S., Roussakis, E., Yaseen, M. A., Srinivasan, V. J., Mandeville, E. T., Devor, A., Lo, E. H., Vinogradov, S. A.*, Boas, D. A.*: Two-photon high-resolution imaging of partial pressure of oxygen in cerebral vasculature and tissue. Nature Methods 7: 755-759, 2010.

Louise E. Sinks, Gregory P. Robbins, Emmanuel Roussakis, Thomas Troxler, Daniel A. Hammer, Sergei A. Vinogradov: Two-Photon Microscopy of Oxygen: Polymersomes as Probe Carrier Vehicles. Journal of Physical Chemistry B 114: 14373-14382, 2010.

Finikova, O. S., Lebedev, A. Y., Aprelev, A., Troxler, T., Gao, F., Garnacho, C., Muro, S., Hochstrasser, R. M., Vinogradov, S. A.: Oxygen microscopy by two-photon-excited phosphorescence. Chemphyschem 9(12): 1673-1679, 2008.

Apreleva, S. V., Wilson, D. F., Vinogradov, S. A.: Tomographic imaging of oxygen by phosphorescence lifetime. Applied Optics 45(33): 8547-8559, 2006.

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Last updated: 08/25/2013
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