Shawn C. Little, Ph.D.

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Assistant Professor of Cell and Developmental Biology
Department: Cell and Developmental Biology

Contact information
1112 Biomedical Research Building II/III
421 Curie Boulevard
Philadelphia, PA 19143
Office: 215-898-7886
Fax: 215-746-5511
B.S. (Biomedical Engineering)
Northwestern University, 1997.
Ph.D. (Department of Cell and Developmental Biology)
University of Pennsylvania, 2008.
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Selected Publications

Zoller Benjamin, Little Shawn C, Gregor Thomas: Diverse spatial expression patterns emerge from unified kinetics of transcriptional bursting. Cell 175(3): 835-847, October 2018.

Little Shawn C, Gregor Thomas: Single mRNA molecule detection in Drosophila. Methods in Molecular Biology. Imre Gaspar (eds.). Humana Press, 1679: 127-142, 2018.

Tikhonov Mikhail, Little Shawn C, Gregor Thomas: Only accessible information is useful: insights from gradient-mediated patterning. Royal Society Open Science 2(11): 150486, Nov 2015.

Little Shawn C, Sinsimer Kristina S, Lee Jack J, Wieschaus Eric F, Gavis Elizabeth R: Independent and coordinate trafficking of single Drosophila germ plasm mRNAs. Nature Cell Biology 17(5): 558-68, May 2015.

Gregor Thomas, Garcia Hernan G, Little Shawn C: The embryo as a laboratory: quantifying transcription in Drosophila. Trends in Genetics 30(8): 364-75, Aug 2014.

Petkova Mariela D, Little Shawn C, Liu Feng, Gregor Thomas: Maternal origins of developmental reproducibility. Current Biology 24(11): 1283-8, Jun 2014.

Little Shawn C, Tikhonov Mikhail, Gregor Thomas: Precise developmental gene expression arises from globally stochastic transcriptional activity. Cell 154(4): 789-800, Aug 2013.

Little Shawn C, Gregor Thomas: Sorting sloppy Sonic. Cell 153(3): 509-10, Apr 2013.

Little Shawn C, Wieschaus Eric F: Shifting patterns: merging molecules, morphogens, motility, and methodology. Developmental Cell 21(1): 2-4, Jul 2011.

Little Shawn C, Tkacik Gasper, Kneeland Thomas B, Wieschaus Eric F, Gregor Thomas: The formation of the Bicoid morphogen gradient requires protein movement from anteriorly localized mRNA. PLoS Biology 9(3): e1000596, Mar 2011.

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Last updated: 11/16/2018
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