Erica Lyn Stone, PhD

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Wistar Institute Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
3601 Spruce Street
Philadelphia, PA 19104
Office: 215-495-6942
Lab: 215-898-3802
B.S. (Biology)
University of New Hampshire, 2003.
Ph.D. (Biology)
University of California San Diego, 2009.
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Description of Research Expertise

The laboratory of Erica L. Stone is investigating T cell biology in the context of specific microenvironments. Currently, the Stone Laboratory is focusing on the influence of tumor microenvironments and the digestive tract on T cell biology. The long-term goal of the lab is to exploit an understanding of the effect of microenvironments on T cell biology to treat diseases including cancer.

Dr. Stone came to Wistar as an Assistant Professor in 2015 from the University of California San Diego. Dr. Stone studied Biology as an undergraduate at the University of New Hampshire and went on to earn a Ph.D. in Biology at the University of California San Diego in 2009. During her Ph.D. she studied glycoimmunology. She then studied T cell biology as a Postdoctoral Fellow in the laboratory of Steve Hedrick at the University of California San Diego. In the Hedrick Laboratory Dr. Stone studied the regulation of T cell differentiation and function by the transcription factor FOXO1 and began to investigate the mutual regulation of immunity and metabolism.

Potential Rotation Projects include:

1. Investigate potential mechanisms that prevent checkpoint blockade efficacy in a subset of
patients – and therapeutic strategies to improve efficacy in these patients.
2. Investigate potential new cancer immunotherapeutic targets.
3. Investigate the effect of the mucosal glycoproteins on oral tolerance induction and
mucosal immunity.
4. Investigate factors that influence oral tolerance through mucosal glycoproteins.

Keywords: T cell biology, Tumor Immunology, Checkpoint blockade, Immunotherapy, Mucosal Immunology

Selected Publications

Stone Erica L, Pepper Marion, Katayama Carol D, Kerdiles Yann M, Lai Chen-Yen, Emslie Elizabeth, Lin Yin C, Yang Edward, Goldrath Ananda W, Li Ming O, Cantrell Doreen A, Hedrick Stephen M: ICOS Coreceptor Signaling Inactivates the Transcription Factor FOXO1 to Promote Tfh Cell Differentiation. Immunity 42(2): 239-51, Feb 2015.

Hannah Kang H, Maripat Corr, Robert Mansson, Eva Welinder, Stephen M Hedrick, Erica L Stone.: Loss of Murine FOXO3 in Cells of the Myeloid Lineage Enhances Myelopoiesis but Protects from K/BxN-Serum Transfer-Induced Arthritis. PLOS One 10(5), May 2015.

Mingueneau Michael, Krishnaswamy Smita, Spitzer Matthew H, Bendall Sean C, Stone Erica L, Hedrick Stephen M, Pe'er Dana, Mathis Diane, Nolan Garry P, Benoist Christophe: Single-cell mass cytometry of TCR signaling: amplification of small initial differences results in low ERK activation in NOD mice. Proceedings of the National Academy of Sciences of the United States of America 111(46): 16466-71, Nov 2014.

Hedrick Stephen M, Hess Michelini Rodrigo, Doedens Andrew L, Goldrath Ananda W, Stone Erica L: FOXO transcription factors throughout T cell biology. Nature reviews. Immunology 12(9): 649-61, Sep 2012.

Ismail Mohd Nazri, Stone Erica L, Panico Maria, Lee Seung Ho, Luu Ying, Ramirez Kevin, Ho Samuel B, Fukuda Minoru, Marth Jamey D, Haslam Stuart M, Dell Anne: High-sensitivity O-glycomic analysis of mice deficient in core 2 {beta}1,6-N-acetylglucosaminyltransferases. Glycobiology 21(1): 82-98, Jan 2011.

Kerdiles Yann M, Stone Erica L, Beisner Daniel R, Beisner Daniel L, McGargill Maureen A, Ch'en Irene L, Stockmann Christian, Katayama Carol D, Hedrick Stephen M: Foxo transcription factors control regulatory T cell development and function. Immunity 33(6): 890-904, Dec 2010.

Lee Seung Ho, Yu Shin-Yi, Nakayama Jun, Khoo Kai-Hooi, Stone Erica L, Fukuda Michiko N, Marth Jamey D, Fukuda Minoru: Core2 O-glycan structure is essential for the cell surface expression of sucrase isomaltase and dipeptidyl peptidase-IV during intestinal cell differentiation. The Journal of biological chemistry 285(48): 37683-92, Nov 2010.

Stone Erica L, Lee Seung Ho, Ismail Mohd Nazri, Fukuda Minoru: Characterization of mice with targeted deletion of the gene encoding core 2 beta1,6-N-acetylglucosaminyltransferase-2. Methods in enzymology 479: 155-72, 2010.

Stone Erica L, Ismail Mohd Nazri, Lee Seung Ho, Luu Ying, Ramirez Kevin, Haslam Stuart M, Ho Samuel B, Dell Anne, Fukuda Minoru, Marth Jamey D: Glycosyltransferase function in core 2-type protein O glycosylation. Molecular and cellular biology 29(13): 3770-82, Jul 2009.

Green Ryan S, Stone Erica L, Tenno Mari, Lehtonen Eero, Farquhar Marilyn G, Marth Jamey D: Mammalian N-glycan branching protects against innate immune self-recognition and inflammation in autoimmune disease pathogenesis. Immunity 27(2): 308-20, Aug 2007.

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Last updated: 01/04/2016
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