Faculty

Patrick J. Grohar, M.D., Ph.D.

faculty photo
Associate Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
Children's Hospital of Philadelphia
Division of Oncology
Department of Pediatrics
3401 Civic Center Boulevard
Philadelphia, PA 19104
Education:
BS (Chemistry)
Villanova University, 1995.
PhD (Chemistry and Biochemistry)
Wayne State University, 2001.
MD
Wayne State University, 2003.
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Description of Research Expertise

The Grohar Lab focuses on developing and clinically translating novel small molecule therapies for the treatment of pediatric solid tumors. A number of pediatric solid tumors have clear oncogenic driver mutations that are considered by many to be “undruggable.” The lab has primarily focused on Ewing sarcoma and the development of therapies that target the EWS-FLI1 transcription factor. More recently, we have extended our focus to other solid tumors with the goal of better understanding therapeutic vulnerabilities at the interface of transcription and epigenetics. We have a number of compounds in various stages of clinical development including a clinical trial based on our laboratory work that is actively accruing patients. We employ high-throughput genetic and chemical screens to identify novel targets and compounds, molecular pharmacology to understand the mechanism of action, and a variety of next-generation sequencing assays to delineate the effects genome-wide.

Selected Publications

Chasse, M. H., Johnson, B. K., Boguslawski, E. A., Sorensen, K. M., Rosien, J. F., Kang, M. H., Reynolds, C. P., Heo, L., Madaj, Z. B., Beddows, I., Foxa, G. E., Kitchen-Goosen, S. M., Williams, B. O., Triche, T. J., Grohar, P. J. : Mithramycin induces promoter reprogramming and differentiation of rhabdoid tumor. EMBO Molecular Medicine Feb 2021.

Kinnaman, M.D, Zhu, C., Weiser, D. A., Mohiuddin, S., Hingorani, P., Roth, M., Gill, J., Janeway, K. A., Gorlick, R., Lessnick, S. L., Grohar, P. J.: Survey of paediatric oncologists and pathologists regarding their views and experiences with variant translocations in Ewing sarcoma. Sarcoma Dec 2020.

Flores, G., Everett J.H., Boguslawski, E. A., Oswald, B. M., Madaj, Z. B., Beddows, I., Dikalov, S., Adams, M., Klumpp-Thomas, C. A., Kitchen-Goosen, S. M., Martin, S. E., Caplen, N. J., Helman, L. J., Grohar, P. J.: CDK9 Blockade Exploits Context-Dependent Transcriptional Changes to Improve Activity and Limit Toxicity of Mithramycin for Ewing Sarcoma. Molecular Cancer Therapeutics 19(5): 1183-1196, May 2020.

Gedminas, JM, Chasse MH, McBrairy M, Beddows I, Kitchen-Goosen, SM, Grohar PJ: Desmoplastic small round cell tumor is dependent on the EWS-WT1 transcription factor. Oncogenesis Apr 2020.

Flores, G., Everett J.H., Boguslawski, E. A., Oswald, B. M., Madaj, Z. B., Beddows, I., Dikalov, S., Adams, M., Klumpp-Thomas, C. A., Kitchen-Goosen, S. M., Martin, S. E., Caplen, N. J., Helman, L. J., Grohar, P. J.: CDK9 Blockade Exploits Context-Dependent Transcriptional Changes to Improve Activity and Limit Toxicity of Mithramycin for Ewing Sarcoma. Molecular Cancer Therapeutics Mar 2020.

Dirksen, U., Grohar, P.J., DuBois, S., Davidson, D.,Hogendoorn, P.C.W., Lessnick, S.L.: Ewing sarcoma. Pediatric Oncology. Pizzo and Poplack (eds.). Page: In press, 2020.

Harlow M.L., Chasse M.H., Boguslawski E.A., Sorensen K.M., Gedminas J.M., Kitchen-Goosen S.M., Rothbart S.B.5., Taslim C., Lessnick S.L., Peck A.S., Madaj Z.B., Bowman M.J., Grohar P.J.: Trabectedin inhibits EWS-FLI1 and evicts SWI/SNF from chromatin in a schedule dependent manner. Clinical Cancer Research 25(11): 3417-3429, Jun 2019.

Sissung T.M., Huang P.A., Hauke, R.J., McCrea, E.M., Peer, C.J., Barbier, R.H., Strope, J.D., Ley, A.M., Zhang, M., Hong, J.A., Venzon, D., Jackson, J.P., Brouwer, K.R., Grohar, P., Glod, J., Widemann, B.C., Heller, T., Schrump, D.S., Figg, W.D.: Severe hepatotoxicity of mithramycin therapy caused by altered expression of hepatocellular bile transporters. Molecular Pharmacology. Epub 2019 Jun 7. 96(2): 158-167, Jun 2019.

Gedminas J.M., Boguslawski E., Kitchen-Goosen S.M., Chasse M.H., Beddows I., Grohar P.J.: Lurbinectedin targets the EWS-WT1 transcription factor in desmoplastic small round cell tumor. Peer Reviewed Poster Presentation, Annual meeting of the American Society of Pediatric Hematology-Oncology, New Orleans, LA May 2019.

Bailey, K.M., Cost, C.R., Davis, I.J., Glade-Bender, J., Grohar, P.J., Houghton, P.J., Isakoff, M.S., Stewart, E., Laack, N., Yustein, J.T., Reed, D.R., Janeway, K.A., Gorlick, R., Lessnick, S.L., DuBois, S.G., Hingorani, P.: Emerging novel agents for patients with advanced Ewing sarcoma: a report from the Children’s Oncology Group (COG) new agents for Ewing sarcoma task force. F1000 Research Page: doi.org/10.12688, Apr 2019 Notes: epub ahead of print.

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Last updated: 06/09/2021
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