Faculty

Casey S. Greene, Ph.D.

faculty photo
Associate Professor of Pharmacology
Department: Pharmacology
Graduate Group Affiliations

Contact information
10-131 Smilow Center for Translational Research
Philadelphia, PA 19104
Education:
B.S. (Chemistry)
Berry College, 2005.
Ph.D. (Computational Genetics)
Dartmouth College, 2009.
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Description of Research Expertise

Our overarching goal is to transform how we understand complex biological systems by developing and applying computational algorithms that effectively model processes by integrating multiple types of big data from diverse experiments. This allows us to infer the key contextual information required to interpret such data, and facilitates both the computationally driven asking and answering of basic science and translational research questions.

Selected Publications

Allen William E, Altae-Tran Han, Briggs James, Jin Xin, McGee Glen, Shi Andy, Raghavan Rumya, Kamariza Mireille, Nova Nicole, Pereta Albert, Danford Chris, Kamel Amine, Gothe Patrik, Milam Evrhet, Aurambault Jean, Primke Thorben, Li Weijie, Inkenbrandt Josh, Huynh Tuan, Chen Evan, Lee Christina, Croatto Michael, Bentley Helen, Lu Wendy, Murray Robert, Travassos Mark, Coull Brent A, Openshaw John, Greene Casey S, Shalem Ophir, King Gary, Probasco Ryan, Cheng David R, Silbermann Ben, Zhang Feng, Lin Xihong: Population-scale longitudinal mapping of COVID-19 symptoms, behaviour and testing. Nature human behaviour Aug 2020.

Talhouk Aline, George Joshy, Wang Chen, Budden Timothy, Tan Tuan Zea, Chiu Derek S, Kommoss Stefan, Leong Huei San, Chen Stephanie, Intermaggio Maria P, Gilks Blake, Nazeran Tayyebeh M, Volchek Mila, Elatre Wafaa, Bentley Rex C, Senz Janine, Lum Amy, Chow Veronica, Sudderuddin Hanwei, Mackenzie Robertson, Leong Samuel C Y, Liu Geyi, Johnson Dustin, Chen Billy, Group Aocs, Alsop Jennifer, Banerjee Susana N, Behrens Sabine, Bodelon Clara, Brand Alison H, Brinton Louise, Carney Michael E, Chiew Yoke-Eng, Cushing-Haugen Kara L, Cybulski Cezary, Ennis Darren, Fereday Sian, Fortner Renée T, García-Donas Jesús, Gentry-Maharaj Aleksandra, Glasspool Rosalind, Goranova Teodora, Greene Casey S, Haluska Paul, Harris Holly R, Hendley Joy, Hernandez Brenda Y, Herpel Esther, Jimenez-Linan Mercedes, Karpinskyj Chloe, Kaufmann Scott H, Keeney Gary L, Kennedy Catherine J, Köbel Martin, Koziak Jennifer M, Larson Melissa C, Lester Jenny, Lewsley Liz-Anne, Lissowska Jolanta, Lubiński Jan, Luk Hugh, Macintyre Geoff, Mahner Sven, McNeish Iain A, Menkiszak Janusz, Nevins Nikilyn, Osorio Ana, Oszurek Oleg, Palacios José, Hinsley Samantha, Pearce Celeste L, Pike Malcolm C, Piskorz Anna M, Ray-Coquard Isabelle, Rhenius Valerie, Rodriguez-Antona Cristina, Sharma Raghwa, Sherman Mark E, De Silva Dilrini, Singh Naveena, Sinn Peter, Slamon Dennis, Song Honglin, Steed Helen, Stronach Euan A, Thompson Pamela J, Tołoczko Aleksandra, Trabert Britton, Traficante Nadia, Tseng Chiu-Chen, Widschwendter Martin, Wilkens Lynne R, Winham Stacey J, Winterhoff Boris, Beeghly-Fadiel Alicia, Benitez Javier, Berchuck Andrew, Brenton James D, Brown Robert, Chang-Claude Jenny, Chenevix-Trench Georgia, deFazio Anna, Fasching Peter A, García María J, Gayther Simon A, Goodman Marc T, Gronwald Jacek, Henderson Michelle J, Karlan Beth Y, Kelemen Linda E, Menon Usha, Orsulic Sandra, Pharoah Paul D P, Wentzensen Nicolas, Wu Anna H, Schildkraut Joellen M, Rossing Mary Anne, Konecny Gottfried E, Huntsman David G, Huang Ruby Yun-Ju, Goode Ellen L, Ramus Susan J, Doherty Jennifer A, Bowtell David D, Anglesio Michael S: Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE). Clinical cancer research : an official journal of the American Association for Cancer Research Jun 2020.

Way, GP, Zietz, M, Rubinetti, V, Himmelstein, DS, Greene, CS: Compressing gene expression data using multiple latent space dimensionalities learns complementary biological representations. Genome Biology 21(1), MAY 11 2020.

Clay, ME, Hammond, JH, Zhong, FF, Chen, XL, Kowalski, CH, Lee, AJ, Porter, MS, Hampton, TH, Greene, CS, Pletneva, EV, Hogan, DA: Pseudomonas aeruginosa lasR mutant fitness in microoxia is supported by an Anr-regulated oxygen-binding hemerythrin. Proceedings of the national academy of sciences of the united states of america 117(6): 3167-3173, FEB 11 2020.

Banerjee, J, Allaway, RJ, Taroni, JN, Baker, A, Zhang, XC, Moon, CI, Pratilas, CA, Blakeley, JO, Guinney, J, Hirbe, A, Greene, CS, Gosline, SJC: Integrative Analysis Identifies Candidate Tumor Microenvironment and Intracellular Signaling Pathways that Define Tumor Heterogeneity in NF1. Genes 11(2), FEB 2020.

Segal, E, Zhang, F, Lin, XH, King, G, Shalem, O, Shilo, S, Allen, WE, Alquaddoomi, F, Altae-Tran, H, Anders, S, Balicer, R, Bauman, T, Bonilla, X, Booman, G, Chan, AT, Cohen, O, Coletti, S, Davidson, N, Dor, Y, Drew, DA, Elemento, O, Evans, G, Ewels, P, Gale, J, Gavrieli, A, Geiger, B, Grad, YH, Greene, CS, Hajirasouliha, I, Jerala, R, Kahles, A, Kallioniemi, O, Keshet, A, Kocarev, L, Landua, G, Meir, T, Muller, A, Nguyen, LH, Oresic, M, Ovchinnikova, S, Peterson, H, Prodanova, J, Rajagopal, J, Ratsch, G, Rossman, H, Rung, J, Sboner, A, Sigaras, A, Spector, T, Steinherz, R, Stevens, I, Vilo, J, Wilmes, P: Building an international consortium for tracking coronavirus health status. Nature medicine 2020.

Hu Qiwen, Greene Casey S, Heller Elizabeth A: Specific histone modifications associate with alternative exon selection during mammalian development. Nucleic acids research 48(9): 4709-4724, 05 2020.

Martinez-Lage Maria, Lynch Timothy M, Bi Yingtao, Cocito Carolina, Way Gregory P, Pal Sharmistha, Haller Josephine, Yan Rachel E, Ziober Amy, Nguyen Aivi, Kandpal Manoj, O'Rourke Donald M, Greenfield Jeffrey P, Greene Casey S, Davuluri Ramana V, Dahmane Nadia: Immune landscapes associated with different glioblastoma molecular subtypes. Acta neuropathologica communications 7(1): 203, Nov 2019.

Rokita Jo Lynne, Rathi Komal S, Cardenas Maria F, Upton Kristen A, Jayaseelan Joy, Cross Katherine L, Pfeil Jacob, Egolf Laura E, Way Gregory P, Farrel Alvin, Kendsersky Nathan M, Patel Khushbu, Gaonkar Krutika S, Modi Apexa, Berko Esther R, Lopez Gonzalo, Vaksman Zalman, Mayoh Chelsea, Nance Jonas, McCoy Kristyn, Haber Michelle, Evans Kathryn, McCalmont Hannah, Bendak Katerina, Böhm Julia W, Marshall Glenn M, Tyrrell Vanessa, Kalletla Karthik, Braun Frank K, Qi Lin, Du Yunchen, Zhang Huiyuan, Lindsay Holly B, Zhao Sibo, Shu Jack, Baxter Patricia, Morton Christopher, Kurmashev Dias, Zheng Siyuan, Chen Yidong, Bowen Jay, Bryan Anthony C, Leraas Kristen M, Coppens Sara E, Doddapaneni HarshaVardhan, Momin Zeineen, Zhang Wendong, Sacks Gregory I, Hart Lori S, Krytska Kateryna, Mosse Yael P, Gatto Gregory J, Sanchez Yolanda, Greene Casey S, Diskin Sharon J, Vaske Olena Morozova, Haussler David, Gastier-Foster Julie M, Kolb E Anders, Gorlick Richard, Li Xiao-Nan, Reynolds C Patrick, Kurmasheva Raushan T, Houghton Peter J, Smith Malcolm A, Lock Richard B, Raman Pichai, Wheeler David A, Maris John M: Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design. Cell reports 29(6): 1675-1689.e9, Nov 2019.

Lin Yu-Hsiu T, Way Gregory P, Barwick Benjamin G, Mariano Margarette C, Marcoulis Makeba, Ferguson Ian D, Driessen Christoph, Boise Lawrence H, Greene Casey S, Wiita Arun P: Integrated phosphoproteomics and transcriptional classifiers reveal hidden RAS signaling dynamics in multiple myeloma. Blood advances 3(21): 3214-3227, Nov 2019.

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Last updated: 11/06/2020
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