Christoph A. Thaiss, Ph.D.

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Assistant Professor of Microbiology
Department: Microbiology

Contact information
3610 Hamilton Walk
Philadelphia, PA 19104
Office: 215-746-7765
Lab: 215-898-2843
B.S. (Molecular Biomedicine)
University of Bonn, Germany, 2010.
M.S. (Immunology and Microbiology)
Yale University & Swiss Federal Institute of Technology (ETH) Zurich, Switzerland, 2012.
Ph.D. (Immunology)
Weizmann Institute of Science, Rehovot, Israel, 2017.
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Description of Research Expertise

The post-Human Genome Project era has highlighted the importance of environmental factors for the development of common human disorders, including metabolic, inflammatory, and neurodegenerative disease. Our goal is to decipher the mechanisms by which these environmental factors, including diet, the light-dark cycle, temperature, xenobiotics and physical activity, are integrated into host physiology. In particular, we study the molecular and cellular pathways of communication between the outside world and the metabolic, immune, and nervous system.
We are using systems biology tools (including single-cell transcriptomics, metagenomics, and metabolomics), coupled to hypothesis-driven research in animal models and human cohorts. Our ultimate goal is to develop innovate new therapies for common human diseases.
Of special interest is the role of the microbiome – the entirety of microorganisms colonizing the human host – as a mediator between the inside and outside world of the human organism. The composition and function of the microbiome is greatly shaped by lifestyle and environmental factors and a critical determinant of disease susceptibility. We are devising new tools to study the microbiome and its communication with other organs of the body.
We are recruiting interested scientists at all levels (rotation students, graduate students, postdocs, research assistants, technicians). For available projects, please contact Christoph Thaiss.

Selected Publications

Thaiss CA*, Itav S*, Rothschild D*, Meijer M, Levy M, Moresi C, Dohnalová L, Braverman S, Rozin S, Malitsky S, Dori-Bachash M, Kuperman Y, Biton I, Gertler A, Harmelin A, Shapiro H, Halpern Z, Aharoni A, Segal E, Elinav E.: Persistent microbiome alterations modulate the rate of post-dieting weight regain. Nature 540: 544–551, November 2016 Notes: (* co-first authors).

Thaiss CA*, Levy M*, Korem T*, Dohnalová L, Shapiro H, Jaitin DA, David E, Winter DR, Gury-BenAri M, Tatirovsky E, Tuganbaev T, Federici S, Zmora N, Zeevi D, Dori-Bachash M, Pevsner-Fischer M, Kartvelishvily E, Brandis A, Harmelin A, Shibolet O, Halpern Z, Honda K, Amit I, Segal E, Elinav E.: Microbiota diurnal rhythmicity programs host transcriptome oscillations. Cell 167(6): 1495-1510, December 2016 Notes: (* co-first authors)

Thaiss CA, Zeevi D*, Levy M*, Zilberman-Schapira G, Suez J, Tengeler AC, Abramson L, Katz MN, Korem T, Zmora N, Kuperman Y, Biton I, Gilad S, Harmelin A, Shapiro H, Halpern Z, Segal E, Elinav E.: Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis. Cell 159(3): 514-29, October 2014 Notes: (* co-first authors).

Thaiss CA*, Zmora N*, Levy M*, Elinav E.: The microbiome and innate community. Nature 535(7610): 65-74, July 2016 Notes: (* co-first authors).

Gury-BenAri M*, Thaiss CA*, Serafini N, Winter DR, Giladi A, Lara-Astiaso D, Levy M, Salame TM, Weiner A, David E, Shapiro H, Dori-Bachash M, Pevsner-Fischer M, Lorenzo-Vivas E, Keren-Shaul H, Paul F, Harmelin A, Eberl G, Itzkovitz S, Tanay A, Di Santo JP, Elinav E, Amit I.: The spectrum and regulatory landscape of intestinal innate lymphoid cells are shaped by the microbiome. Cell 166(5): 1231-1246, August 2016 Notes: (* co-first authors).

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Last updated: 06/11/2020
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