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Donald M. O'Rourke, M.D.

John Templeton, Jr., M.D. Professor in Neurosurgery
Faculty , Abramson Family Cancer Center, Cell and Development Biology Program, Cancer Biology Program, Translational Studies Program, University of Pennsylvania
Founding Member, Center for Cancer Pharmacology, University of Pennsylvania
Director, Human Brain Tumor Tissue Bank, University of Pennsylvania
Faculty Member, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania
Full Member, Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania
Founding Member, Philadelphia Coalition for a Cure (PC4C), The Children's Hospital of Philadelphia, University of Pennsylvania
Mack Technology Fellow, Mack Institute for Innovation Management, The Wharton School, University of Pennsylvania, University of Pennsylvania
Director, Glioblastoma Translational Center of Excellence, Abramson Cancer Center
Faculty, Penn Center for Cellular Immunotherapies
Department: Neurosurgery

Contact information
HUP - 15th floor, South Perelman
3401 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-662-3490
Fax: 215-349-5534
A.B. (Biochemistry and Molecular Biology)
Harvard University (Magna Cum Laude), 1983.
M.D. (Medicine)
University of Pennsylvania, 1987.
M.A. (Arts)
University of Pennsylvania, 2002.
Post-Graduate Training
Intern in General Surgery, Hospital of the University of Pennsylvania, Philadelphia, 1987-1988.
Resident in Neurosurgery, University of Pennsylvania, Philadelphia, 1988-1994.
Postdoctoral Research Fellow, M.D., University of Pennsylvania School of Medicine, Department of Pathology and Laboratory Medicine, 1994-1996.
Diplomate, National Board of Medical Examiners, 1988.
Diplomate, American Board of Neurological Surgeons, 1998.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Selected Publications

Nabavizadeh A, Bagley SJ, Doot RK, Ware JB, Young AJ, Ghodasara S, Zhao C, Anderson H, Schubert E, Carpenter EL, Till J, Henderson F Jr, Pantel AR, Chen HI, Lee JYK, Amankulor NM, O'Rourke DM, Desai A, Nasrallah MP, Brem S.: Distinguishing Progression from Pseudoprogression in Glioblastoma Using 18F-Fluciclovine PET. J Nucl Med 64(6), June 2023 Notes: Epub 2022 Dec 22.

de Godoy LL, Chawla S, Brem S, Wang S, O'Rourke DM, Nasrallah MP, Desai A, Loevner LA, Liau LM, Mohan S: Assessment of treatment response to dendritic cell vaccine in patients with glioblastoma using a multiparametric MRI-based prediction model. J Neurooncol 163(1), May 2023 Notes: Epub 2023 May 2.

de Godoy LL, Mohan S, Wang S, Nasrallah MP, Sakai Y, O'Rourke DM, Bagley S, Desai A, Loevner LA, Poptani H, Chawla S: Validation of multiparametric MRI based prediction model in identification of pseudoprogression in glioblastomas. J Transl Med 21(1), Apr 2023.

Hosseini SA, Hosseini E, Hajianfar G, Shiri I, Servaes S, Rosa-Neto P, Godoy L, Nasrallah MP, O'Rourke DM, Mohan S, Chawla S.: MRI-Based Radiomics Combined with Deep Learning for Distinguishing IDH-Mutant WHO Grade 4 Astrocytomas from IDH-Wild-Type Glioblastomas. Cancers (Basel) 15(3), Feb 2023.

Reed-Guy L, Desai AS, Phillips RE, Croteau D, Albright K, O'Neill M, Brem S, O'Rourke DM, Amankulor NM, Bagley SJ.: Risk of intracranial hemorrhage with direct oral anticoagulants vs low molecular weight heparin in glioblastoma: A retrospective cohort study. Neuro Oncol 24(12): 2172-2179, Dec 2022.

Song EZ, Wang X, Philipson BI, Zhang Q, Thokala R, Zhang L, Assenmacher CA, Binder ZA, Ming GL, O'Rourke DM, Song H, Milone MC: The IAP antagonist birinapant enhances chimeric antigen receptor T cell therapy for glioblastoma by overcoming antigen heterogeneity. Mol Therapy Oncolytics 27(288-304): 288-304, Nov 2022 Notes: eCollection 2022 Dec 15.

Bakas S, Sako C, Akbari H, Bilello M, Sotiras A, Shukla G, Rudie JD, SantamarĂ­a NF, Kazerooni AF, Pati S, Rathore S, Mamourian E, Ha SM, Parker W, Doshi J, Baid U, Bergman M, Binder ZA, Verma R, Lustig RA, Desai AS, Bagley SJ, Mourelatos Z, Morrissette J, Watt CD, Brem S, Wolf RL, Melhem ER, Nasrallah MP, Mohan S, O'Rourke DM, Davatzikos C: The University of Pennsylvania glioblastoma (UPenn-GBM) cohort: advanced MRI, clinical, genomics, & radiomics. Sci Data 9(1): 453, July 2022.

Alanio C, Binder ZA, Chang RB, Nasrallah MP, Delman D, Li JH, Tang OY, Zhang LY, Zhang JV, Wherry EJ, O'Rourke DM, Beatty GL.: Immunological features in de novo and recurrent glioblastoma are associated with survival outcomes. Cancer Immunol Res. 10(7): 800-10, july 2022.

Yin Y, Rodriguez JL, Li N, Thokala R, Nasrallah MP, Hu L, Zhang L, Zhang JV, Logun MT, Kainth D, Haddad L, Zhao Y, Wu T, Johns EX, Long Y, Liang H, Qi J, Zhang X, Binder ZA, Lin Z, O'Rourke DM: Locally secreted BiTEs complement CAR T cells by enhancing killing of antigen heterogeneous solid tumors. Mol. Ther. 30(7): 2537-2553, July 2022.

Fathi Kazerooni A, Saxena S, Toorens E, Tu D, Bashyam V, Akbari H, Mamourian E, Sako C, Koumenis C, Verginadis I, Verma R, Shinohara RT, Desai AS, Lustig RA, Brem S, Mohan S, Bagley SJ, Ganguly T, O'Rourke DM, Bakas S, Nasrallah MP, Davatzikos C.: Clinical measures, radiomics, and genomics offer synergistic value in AI-based prediction of overall survival in patients with glioblastoma. Sci Rep 12(1), May 2022.

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Last updated: 07/17/2023
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