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Donald M. O'Rourke, M.D.

John Templeton, Jr., M.D. Professor in Neurosurgery
Faculty , Abramson Family Cancer Center, Cell and Development Biology Program, Cancer Biology Program, Translational Studies Program, University of Pennsylvania
Founding Member, Center for Cancer Pharmacology, University of Pennsylvania
Director, Human Brain Tumor Tissue Bank, University of Pennsylvania
Faculty Member, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania
Full Member, Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania
Founding Member, Philadelphia Coalition for a Cure (PC4C), The Children's Hospital of Philadelphia, University of Pennsylvania
Mack Technology Fellow, Mack Institute for Innovation Management, The Wharton School, University of Pennsylvania, University of Pennsylvania
Director, Glioblastoma Translational Center of Excellence, Abramson Cancer Center
Faculty, Penn Center for Cellular Immunotherapies
Department: Neurosurgery

Contact information
HUP - 3 Silverstein
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3490
Fax: 215-349-5534
Graduate Group Affiliations
Education:
A.B. (Biochemistry and Molecular Biology)
Harvard University (Magna Cum Laude), 1983.
M.D. (Medicine)
University of Pennsylvania, 1987.
M.A. (Arts)
University of Pennsylvania, 2002.
Post-Graduate Training
Intern in General Surgery, Hospital of the University of Pennsylvania, Philadelphia, 1987-1988.
Resident in Neurosurgery, University of Pennsylvania, Philadelphia, 1988-1994.
Postdoctoral Research Fellow, M.D., University of Pennsylvania School of Medicine, Department of Pathology and Laboratory Medicine, 1994-1996.
Certifications
Diplomate, National Board of Medical Examiners, 1988.
Diplomate, American Board of Neurological Surgeons, 1998.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Selected Publications

Henderson F Jr, Brem S, O'Rourke DM, Nasrallah M, Buch VP, Young AJ, Doot RK, Pantel A, Desai A, Bagley SJ, Nabavizadeh SA.: 18F-Fluciclovine PET to distinguish treatment-related effects from disease progression in recurrent glioblastoma: PET fusion with MRI guides neurosurgical sampling. Neurooncol Pract 7(2): 152-7, March 2020 Notes: Epub 2019 Dec 8.

Davatzikos C, Barnholtz-Sloan JS, Bakas S, Colen R, Mahajan A, Quintero CB, Font JC, Puig J, Jain R, Sloan AE, Badve C, Marcus DS, Choi YS, Lee SK, Chang JH, Poisson LM, Griffith B, Dicker AP, Flanders AE, Booth TC, Rathore S, Akbari H, Sako C, Bilello M, Shukla G, Kazerooni AF, Brem S, Lustig R, Mohan S, Bagley S, Nasrallah M, O'Rourke DM: AI-based Prognostic Imaging Biomarkers for Precision Neurooncology: the ReSPOND Consortium. Neuro Oncol March 2020 Notes: pii: noaa045. doi: 10.1093/neuonc/noaa045. [Epub ahead of print]

Fathi Kazerooni A, Akbari H, Shukla G, Badve C, Rudie JD, Sako C, Rathore S, Bakas S, Pati S, Singh A, Bergman M, Ha SM, Kontos D, Nasrallah M, Bagley SJ, Lustig RA, O'Rourke DM, Sloan AE, Barnholtz-Sloan JS, Mohan S, Bilello M, Davatzikos C: Cancer Imaging Phenomics via CaPTk: Multi-Institutional Prediction of Progression-Free Survival and Pattern of Recurrence in Glioblastoma. JCO Clin Cancer Inform 4: 234-244, March 2020.

Akbari H, Rathore S, Bakas S, Nasrallah MP, Shukla G, Mamourian E, Rozycki M, Bagley SJ, Rudie JD, Flanders AE, Dicker AP, Desai AS, O'Rourke DM, Brem S, Lustig R, Mohan S, Wolf RL, Bilello M, Martinez-Lage M, Davatzikos C: Histopathology-validated machine learning radiographic biomarker for noninvasive discrimination between true progression and pseudo-progression in glioblastoma. Cancer March 2020 Notes: [Epub ahead of print]

Reardon DA, Desjardins A, Vredenburgh JJ, O'Rourke DM, Tran DD, Fink KL, Nabors LB, Li G, Bota DA, Lukas RV, Ashby LS, Duic JP, Mrugala MM, Cruickshank S, Vitale L, He Y, Green JA, Yellin MJ, Turner CD, Keler T, Davis TA, Sampson JH; ReACT trial investigators: Rindopepimut with Bevacizumab for Patients with Relapsed EGFRvIII-Expressing Glioblastoma (ReACT): Results of a Double-Blind Randomized Phase II Trial. Clin Cancer Res February 2020 Notes: CCR-18-1140. [Epub ahead of print]

Huang M, Zhang D, Wu JY, Xing K, Yeo E, Li C, Zhang L, Holland E, Yao L, Qin L, Binder ZA, O'Rourke DM, Brem S, Koumenis C, Gong Y, Fan Y.: Wnt-mediated endothelial transformation into mesenchymal stem cell-like cells induces chemoresistance in glioblastoma. Sci Transl Med 12: 532, February 2020 Notes: pii: eaay7522.

Nabavizadeh SA, Ware JB, Guiry S, Nasrallah MP, Mays JJ, Till JE, Hussain J, Abdalla A, Yee SS, Binder ZA, O'Rourke DM, Brem S, Desai AS, Wolf R, Carpenter EL, Bagley SJ.: Imaging and histopathologic correlates of plasma cell-free DNA concentration and circulating tumor DNA in adult patients with newly diagnosed glioblastoma. Neurooncol Adv 2(1), Jan-Dec 2020 Notes: vdaa016. doi: 10.1093/noajnl/vdaa016. Epub 2020 Feb 27.

Kvint S, Ramchand P, Cox M, Sedora-Roman NI, Bagley L, O'Rourke DM, Hurst RW, Choudhri OA: Type V Dural Arteriovenous Fistula Supplied by the Artery of Wollschlaeger and Wollschlaeger Causing Cervical Myelopathy and Quadriparesis. World Neurosurg 137: 55-61, January 2020 Notes: [Epub ahead of print]

S Mohan, S Wang, G Coban, F Kural, S Chawla, D O’Rourke, H Poptani: Detection of Occult Neoplastic Infiltration in the Corpus Callosum and Prediction of Overall Survival in Patients with Glioblastoma using Diffusion Tensor Imaging. European Journal of Radiology January 2019

Rathore S, Akbari H, Bakas S, Pisapia JM, Shukla G, Rudie JD, Da X, Davuluri RV, Dahmane N, O'Rourke DM, Davatzikos C.: Multivariate Analysis of Preoperative Magnetic Resonance Imaging Reveals Transcriptomic Classification of de novo Glioblastoma Patients. Front Comput Neurosci 13(81), December 2019.

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Last updated: 03/26/2020
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