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Donald M. O'Rourke, M.D.

John Templeton, Jr., M.D. Professor in Neurosurgery
Faculty , Abramson Family Cancer Center, Cell and Development Biology Program, Cancer Biology Program, Translational Studies Program, University of Pennsylvania
Founding Member, Center for Cancer Pharmacology, University of Pennsylvania
Director, Human Brain Tumor Tissue Bank, University of Pennsylvania
Faculty Member, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania
Full Member, Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania
Founding Member, Philadelphia Coalition for a Cure (PC4C), The Children's Hospital of Philadelphia, University of Pennsylvania
Mack Technology Fellow, Mack Institute for Innovation Management, The Wharton School, University of Pennsylvania, University of Pennsylvania
Director, Glioblastoma Translational Center of Excellence, Abramson Cancer Center
Faculty, Penn Center for Cellular Immunotherapies
Department: Neurosurgery

Contact information
HUP - 3 Silverstein
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-3490
Fax: 215-349-5534
A.B. (Biochemistry and Molecular Biology)
Harvard University (Magna Cum Laude), 1983.
M.D. (Medicine)
University of Pennsylvania, 1987.
M.A. (Arts)
University of Pennsylvania, 2002.
Post-Graduate Training
Intern in General Surgery, Hospital of the University of Pennsylvania, Philadelphia, 1987-1988.
Resident in Neurosurgery, University of Pennsylvania, Philadelphia, 1988-1994.
Postdoctoral Research Fellow, M.D., University of Pennsylvania School of Medicine, Department of Pathology and Laboratory Medicine, 1994-1996.
Diplomate, National Board of Medical Examiners, 1988.
Diplomate, American Board of Neurological Surgeons, 1998.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Selected Publications

Durgin JS, Henderson F Jr, Nasrallah MP, Mohan S, Wang S, Lacey SF, Melenhorst JJ, Desai AS, Lee JYK, Maus MV, June CH, Brem S, O'Connor RS, Binder Z, O'Rourke DM: Case Report: Prolonged Survival Following EGFRvIII CAR T Cell Treatment for Recurrent Glioblastoma. Front Oncol 7(11): 669071, May 2021 Notes: eCollection 2021.

Rathore S, Mohan S, Bakas S, Sako C, Badve C, Pati S, Singh A, Bounias D, Ngo P, Akbari H, Gastounioti A, Bergman M, Bilello M, Shinohara RT, Yushkevich P, O'Rourke DM, Sloan AE, Kontos D, Nasrallah MP, Barnholtz-Sloan JS, Davatzikos C: Multi-institutional noninvasive in vivo characterization of IDH, 1p/19q, and EGFRvIII in glioma using neuro-Cancer Imaging Phenomics Toolkit (neuro-CaPTk). Neurooncol Adv 23(2 (Suppl 4)): iv22-iv34, Jan 2021 Notes: eCollection 2020 Dec.

Wenjuan Ma, Yanling Wang, Rongxin Zhang, Fan Yang, Duo Zhang, Menggui Huang, Lin Zhang, Jay F Dorsey, Zev A Binder, Donald M O’Rourke, Joseph A Fraietta, Yanqing Gong, Yi Fan: Targeting PAK4 to reprogram the vascular microenvironment and improve CAR-T immunotherapy for glioblastoma. Nature Cancer 2(1): 83-97, Jan 2021.

Bagley SJ, Till J, Abdalla A, Sangha HK, Yee SS, Freedman J, Black TA, Hussain J, Binder ZA, Brem S, Desai AS, O'Rourke DM, Long Q, Nabavizadeh SA, Carpenter E: Association of plasma cell-free DNA with survival in patients with IDH wild-type glioblastoma. Neurooncol Adv 3(1): vdab011, Jan 2021 Notes: eCollection 2021 Jan-Dec.

Tarrant JC, Binder ZA, Bugatti M, Vermi W, van den Oord J, Ranieri B, Assenmacher CA, Hoepp N, O'Rourke DM, Shan X, Danet-Desnoyers G, Radaelli E: Pathology of macrophage activation syndrome in humanized NSGS mice. Res Vet Sci 134: 137-146, Jan 2021 Notes: Epub 2020 Dec 16.

R Thokala, ZA Binder, L Zhang, JV Zhang, DY Zhang, MC Milone, DM O'Rourke: High Affinity Chimeric Antigen Receptor with Cross-Reactive scFv to Clinically Relevant EGFR Oncogenic Isoforms. BioRxiv 2021.

Mallela AN, Agarwal P, Goel NJ, Durgin J, Jayaram M, O'Rourke DM, Brem S, Abdullah KG: An additive score optimized by a genetic learning algorithm predicts readmission risk after glioblastoma resection. J Clin Neurosci 80: 1-5, October 2020 Notes: Epub 2020 Aug 17.

Nasrallah MLP, Desai A, O'Rourke DM, Surrey LF, Stein JM: A dual-genotype oligoastrocytoma with histologic, molecular, radiological and time-course features. Acta Neuropathol Commun 8(1): 115, Jul 2020.

Akbari H, Rathore S, Bakas S, Nasrallah MP, Shukla G, Mamourian E, Rozycki M, Bagley SJ, Rudie JD, Flanders AE, Dicker AP, Desai AS, O'Rourke DM, Brem S, Lustig R, Mohan S, Wolf RL, Bilello M, Martinez-Lage M, Davatzikos C: Histopathology-validated machine learning radiographic biomarker for noninvasive discrimination between true progression and pseudo-progression in glioblastoma. Cancer 126(11): 2625-2636, June 2020 Notes: Epub 2020 Mar 4.

Davatzikos C, Barnholtz-Sloan JS, Bakas S, Colen R, Mahajan A, Quintero CB, Capellades Font J, Puig J, Jain R, Sloan AE, Badve C, Marcus DS, Seong Choi Y, Lee SK, Chang JH, Poisson LM, Griffith B, Dicker AP, Flanders AE, Booth TC, Rathore S, Akbari H, Sako C, Bilello M, Shukla G, Fathi Kazerooni A, Brem S, Lustig R, Mohan S, Bagley S, Nasrallah M, O'Rourke DM: AI-based prognostic imaging biomarkers for precision neuro-oncology: the ReSPOND consortium. Neuro Oncol 22(6): 886-888, June 2020.

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Last updated: 06/10/2021
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