Donald M. O'rourke - Faculty Biosketch

Donald M. O'Rourke, M.D.

John Templeton, Jr., M.D. Professor in Neurosurgery

Faculty , Abramson Family Cancer Center, Cell and Development Biology Program, Cancer Biology Program, Translational Studies Program, University of Pennsylvania

Founding Member, Center for Cancer Pharmacology, University of Pennsylvania

Director, Human Brain Tumor Tissue Bank, University of Pennsylvania

Faculty Member, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania

Full Member, Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania

Founding Member, Philadelphia Coalition for a Cure (PC4C), The Children's Hospital of Philadelphia, University of Pennsylvania

Mack Technology Fellow, Mack Institute for Innovation Management, The Wharton School, University of Pennsylvania, University of Pennsylvania

Director, Glioblastoma Translational Center of Excellence, Abramson Cancer Center

Faculty, Penn Center for Cellular Immunotherapies

Department: Neurosurgery

Contact information

HUP - 15th floor, South Perelman
3401 Civic Center Boulevard
Philadelphia, PA 19104

Office: 215-662-3490
Fax: 215-349-5534

Email:
donald.orourke@uphs.upenn.edu

Publications

Search PubMed for articles

Links
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Education:
A.B. (Biochemistry and Molecular Biology)
Harvard University (Magna Cum Laude), 1983.
M.D. (Medicine)
University of Pennsylvania, 1987.
M.A. (Arts)
University of Pennsylvania, 2002.

Post-Graduate Training
Intern in General Surgery, Hospital of the University of Pennsylvania, Philadelphia, 1987-1988.
Resident in Neurosurgery, University of Pennsylvania, Philadelphia, 1988-1994.
Postdoctoral Research Fellow, M.D., University of Pennsylvania School of Medicine, Department of Pathology and Laboratory Medicine, 1994-1996.

Certifications
Diplomate, National Board of Medical Examiners, 1988.
Diplomate, American Board of Neurological Surgeons, 1998.

Permanent link

> Perelman School of Medicine > Faculty > Details

Selected Publications

Bagley SJ, Logun M, Fraietta JA, Wang X, Desai AS, Bagley LJ, Nabavizadeh A, Jarocha D, Martins R, Maloney E, Lledo L, Stein C, Marshall A, Leskowitz R, Jadlowsky JK, Christensen S, Oner BS, Plesa G, Brennan A, Gonzalez V, Chen F, Sun Y, Gladney W, Barrett D, Nasrallah MP, Hwang WT, Ming GL, Song H, Siegel DL, June CH, Hexner EO, Binder ZA, O'Rourke DM: Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results. Nat Med. 30(5): 1320-1329, May 2024.

Reynolds DE, Sun Y, Wang X, Vallapureddy P, Lim J, Pan M, Fernandez Del Castillo A, Carlson JCT, Sellmyer MA, Nasrallah M, Binder Z, O'Rourke DM, Ming GL, Song H, Ko J.: Live Organoid Cyclic Imaging. Add Sci (Weinh) 11(14): e2309289, Apr 2024.

Sun Y, Wang X, Zhang DY, Zhang Z, Bhattarai JP, Wang Y, Dong W, Zhang F, Park KH, Galanaugh J, Sambangi A, Yang Q, Kim SH, Wheeler G, Goncalves T, Wang Q, Geschwind D, Kawaguchi R, Wang H, Xu F, Binder ZA, Chen IH, Pai EL, Stone S, Nasrallah M, Christian KM, Fuccillo M, O'Rourke DM, Ma M, Ming GL, Song H: Brain-wide neuronal circuit connectome of human glioblastoma. bioRxiv [Preprint] Page: 03.01.583047, Mar 2024.

Bagley SJ, Binder ZA, Lamrani L, Marinari E, Desai AS, Nasrallah MP, Maloney E, Brem S, Lustig RA, Kurtz G, Alonso-Basanta M, Bonté PE, Goudot C, Richer W, Piaggio E, Kothari S, Guyonnet L, Guerin CL, Waterfall JJ, Mohan S, Hwang WT, Tang OY, Logun M, Bhattacharyya M, Markowitz K, Delman D, Marshall A, Wherry EJ, Amigorena S, Beatty GL, Brogdon JL, Hexner E, Migliorini D, Alanio C, O'Rourke DM: Repeated peripheral infusions of anti-EGFRvIII CAR T cells in combination with pembrolizumab show no efficacy in glioblastoma: a phase 1 trial. Nat Cancer 5(3): 517-31, Mar 2024.

Guo J, Fathi Kazerooni A, Toorens E, Akbari H, Yu F, Sako C, Mamourian E, Shinohara RT, Koumenis C, Bagley SJ, Morrissette JJD, Binder ZA, Brem S, Mohan S, Lustig RA, O'Rourke DM, Ganguly T, Bakas S, Nasrallah MP, Davatzikos C.: Integrating imaging and genomic data for the discovery of distinct glioblastoma subtypes: a joint learning approach. Sci Rep. 28(14 (1)): 4922, Feb 2024.

Logun M, Wang X, Sun YY, Bagley S, Li N, Desai A, Zhang DY, Nasrallah M, Pai EL, Oner BS, Plesa G, Siegel D, Binder ZA, Ming GL, Song H, O’Rourke DM: Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy. BioRxiv 2024.

Zhang DY, Wang X, Sun Y, Cui Q, Nelson E, Zhang Z, Huang B, Giles J, Thokala R, Connolly DR, Jacob F, Wherry EJ, Lucas T, Chen HI, Shi Y, Brem S, Binder ZA, Nasrallah MP, Salinas RD, O'Rourke DM*, Ming G-L* and Song H: Temporal multi-modal single-cell analyses reveal dynamic interactions of CAR-T cells with glioblastoma and targeting of antigen-negative neoplastic cells BioRxiv 2024.

de Godoy LL, Lim KC, Rajan A, Verma G, Hanaoka M, O'Rourke DM, Lee JYK, Desai A, Chawla S, Mohan S. : Non-Invasive Assessment of Isocitrate Dehydrogenase-Mutant Gliomas Using Optimized Proton Magnetic Resonance Spectroscopy on a Routine Clinical 3-Tesla MRI. 2023 Sep 7;15(18):4453. Cancers (Basel) 7(15): 4453, Sept 2023.

Lee MD, Patel SH, Mohan S, Akbari H, Bakas S, Nasrallah MP, Calabrese E, Rudie J, Villanueva-Meyer J, LaMontagne P, Marcus DS, Colen RR, Balana C, Choi YS, Badve C, Barnholtz-Sloan JS, Sloan AE, Booth TC, Palmer JD, Dicker AP, Flanders AE, Shi W, Griffith B, Poisson LM, Chakravarti A, Mahajan A, Chang S, Orringer D, Davatzikos C, Jain R; ReSPOND Consortium: Association of partial T2-FLAIR mismatch sign and isocitrate dehydrogenase mutation in WHO grade 4 gliomas: results from the ReSPOND consortium. Neuroradiology 65(9): 1343-52, Sep 2023.

Nabavizadeh A, Bagley SJ, Doot RK, Ware JB, Young AJ, Ghodasara S, Zhao C, Anderson H, Schubert E, Carpenter EL, Till J, Henderson F Jr, Pantel AR, Chen HI, Lee JYK, Amankulor NM, O'Rourke DM, Desai A, Nasrallah MP, Brem S.: Distinguishing Progression from Pseudoprogression in Glioblastoma Using 18F-Fluciclovine PET. J Nucl Med 64(6), June 2023 Notes: Epub 2022 Dec 22.