Faculty

Bhavya S Doshi, MD

Assistant Professor of Pediatrics (Hematology) at the Children's Hospital of Philadelphia

Department: Pediatrics

Graduate Group Affiliations

Cell and Molecular Biology

Contact information

Children's Hospital of Philadelphia
3501 Civic Center Boulevard
CTRB 5024
Philadelphia, PA 19104

Office: 267-425-7973
Fax: 215-590-3992

Publications

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Education:
BS (Biology)
Emory University, 2008.
MD
Emory University School of Medicine, 2012.

Links
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Permanent link

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Description of Clinical Expertise

Disorders of hemostasis and thrombosis with a focus on hemophilia and inhibitor development as well as laboratory diagnosis of coagulation disorders.

Description of Research Expertise

My laboratory studies the development of neutralizing alloantibodies ("inhibitors") in hemophilia. We are interested in improving the understanding of the drivers of inhibitor development with a current focus on pathways that regulate B and T cell development in the evolving immune response with the goal to leverage these findings to identify new therapies to prevent and/or treat inhibitors. Additionally, the lab is pursuing collaborative work to understand antibodies that complicate delivery of hemophilia gene therapy. Finally, in my capacity as Assistant Director of the Children's Hospital of Philadelphia Special Coagulation Laboratory, I am interested in identifying clinical factors that improve laboratory diagnostic pathways for patients with hemostatic and thrombotic disorders.

Selected Publications

Doshi BS, Rana J, Castaman G, Shaheen MA, Kaczmarek R, Butterfield JSS, Meeks SL, Leissinger C, Biswas M*, Arruda VR*: B cell activating factor modulates the factor VIII immune response in hemophilia A. J Clin Invest 131(8): e142906, Apr 2021.

Doshi BS, Rogers RS, Whitworth HB, Stabnick EA, Britton J, Butler RB, Obstfeld A, and Witmer CM: Utility of Repeat Testing in the Evaluation for von Willebrand Disease in Pediatric Patients. J Thromb Haemost 17(11): 1838-47, Nov 2019.

Doshi BS, Raffini LJ, George LA: Combined Anti-CD20 and mTOR Inhibition with Factor VIII for Immune Tolerance Induction in Hemophilia A Patients with Refractory Inhibitors. J Thromb Haemost 18(4): 848-852, Apr 2020.

Doshi BS, Witmer CM: Recurrence of a high titer factor VIII inhibitor in a hemophilia A patient on emicizumab prophylaxis. Haemophilia 27(4): e551-e553, Jul 2021.

Doshi BS, Kamdar A, Lambert MP, Obstfeld A: Hemolysis after medication exposure in pediatric patients with G6PD deficiency. J Pediatr Hematol Oncol 44(5): 261-263, Jul 2022.

Doshi BS, Ellison AM: Diagnosis and Management of Pediatric Venous Thromboembolism: New Therapies on the Horizon. Pediatric Emergency Care 37(5): 273-279, May 2021.

Doshi BS, Arruda VR: Gene therapy for hemophilia: what does the future hold? Ther Adv Hematol 9(9): 273-293, Aug 27 2018.

Arruda VR, Doshi BS: Gene therapy for hemophilia: facts and quandaries in the 21st century. Mediterr J Hematol Infect Dis 12(1): e2020069, Aug 2020.

Meeks SL, Cox CL, Healey JF, Parker ET, Doshi BS, Gangadharan B, Barrow RT, Lollar P: A major determinant of the immunogenicity of factor VIII in a murine model is independent of its procoagulant function. Blood 120(12): 2512-20, Sep 2012.

Doshi BS, Gangadharan B, Doering CB, Meeks SL.: Potentiation of thrombin generation in hemophilia A plasma by coagulation factor VIII and characterization of antibody-specific inhibition. PloS One 7(10): e48172, 2012.