Shawn C. Little

faculty photo
Assistant Professor of Cell and Developmental Biology
Department: Cell and Developmental Biology

Contact information
1112 Biomedical Research Building II/III
421 Curie Boulevard
Philadelphia, PA 19143
Office: 215-898-7886
Fax: 215-746-5511
B.S. (Biomedical Engineering)
Northwestern University, 1997.
Ph.D. (Department of Cell and Developmental Biology)
University of Pennsylvania, 2008.
Post-Graduate Training
Research Assistant in Microbiology and Immunology, Loyola University Medical Center , 1998-2001.
Postdoctoral Research Associate in Molecular Biology, Princeton University, 2008-2016.
Postdoctoral Research Associate in Cell and Developmental Biology, University of Pennsylvania , 2008-2008.
Permanent link
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Selected Publications

Aleman JR, Kuhn TM, Pascual-Garcia P, Gospocic J, Lan Y, Bonasio R, Little SC, Capelson M: Correct dosage of X chromosome transcription is controlled by a nuclear pore component. Cell Reports 35(11), June 2021.

Pascual-Garcia P, Capelson M, and Little SC: Nup98-dependent amplification of transcriptional potential occurs independently of transcription. Elife Accepted 2021.

Sheng L, Shields EJ, Gospocic J, Glastad KM, Ratchasanmuang P, Berger SL, Raj A, Little SC, and Bonasio R: Social reprogramming in ants induces longevity-associated glia remodeling. Science Advances August 2020.

Kuhn T, Little SC, and Capelson M: Preparation of Drosophila polytene chromosomes, followed by immunofluorescence analysis of chromatin structure by multi-fluorescence correlations. Bio-protocol 10, July 2020.

Fasolino M, Goldman N, Wang W, Cattau B, Zhou Y, Petrovic J, Link V, Cote A, Chandra A, Silverman M, Joyce EF, Little SC, HPAP consortium, Kaestner KH, Naji A, Raj A, Henao-Mejia J, Faryabi RB, and Vahedi G.: Genetic variation in type 1 diabetes reconfigures the 3D chromatin organization of T cells and alters gene expression. Immunity 52, February 2020.

Kuhn T, Pascual-Garcia P, Gozalo A, Little SC, Capelson M: Chromatin targeting of nuclear pore proteins induces decondensation. J Cell Biol 218(9), Sept 2019.

Hui Chen, Lily C. Einstein, Shawn C. Little, Matthew C. Good: Spatiotemporal Patterning of Zygotic Genome Activation In A Model Vertebrate Embryo. Dev Cell June 2019.

Petrovic J, Zhou Y, Fasolino M, Goldman N, Schwartz GW, Mumbach MR, Nguyen SC, Rome KS, Sela Y, Zapataro Z, Blacklow SC, Kruhlak MJ, Shi J, Aster JC, Joyce EF, Little SC, Vahedi G, Pear WS, Faryabi RB: Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques. Mol Cell 73(6): 1174-1190, March 2019.

Zoller Benjamin, Little Shawn C, Gregor Thomas: Diverse spatial expression patterns emerge from unified kinetics of transcriptional bursting. Cell 175(3): 835-847, October 2018.

Little Shawn C, Gregor Thomas: Single mRNA molecule detection in Drosophila. Methods in Molecular Biology. Imre Gaspar (eds.). Humana Press, 1679: 127-142, January 2018.

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Last updated: 10/06/2021
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