Faculty

Patrick J. Grohar, M.D., Ph.D.

faculty photo
Associate Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
Children's Hospital of Philadelphia
Division of Oncology
Department of Pediatrics
3401 Civic Center Boulevard
Philadelphia, PA 19104
Education:
BS (Chemistry)
Villanova University, 1995.
PhD (Chemistry and Biochemistry)
Wayne State University, 2001.
MD
Wayne State University, 2003.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Selected Publications

Gedminas, JM, Chasse MH, McBrairy M, Beddows I, Kitchen-Goosen, SM, Grohar PJ: Desmoplastic small round cell tumor is dependent on the EWS-WT1 transcription factor. Oncogenesis Apr 2020.

Flores, G., Everett J.H., Boguslawski, E. A., Oswald, B. M., Madaj, Z. B., Beddows, I., Dikalov, S., Adams, M., Klumpp-Thomas, C. A., Kitchen-Goosen, S. M., Martin, S. E., Caplen, N. J., Helman, L. J., Grohar, P. J.: CDK9 Blockade Exploits Context-Dependent Transcriptional Changes to Improve Activity and Limit Toxicity of Mithramycin for Ewing Sarcoma. Molecular Cancer Therapeutics Mar 2020.

Dirksen, U., Grohar, P.J., DuBois, S., Davidson, D.,Hogendoorn, P.C.W., Lessnick, S.L.: Ewing sarcoma. Pediatric Oncology. Pizzo and Poplack (eds.). Page: In press, 2020.

Harlow M.L., Chasse M.H., Boguslawski E.A., Sorensen K.M., Gedminas J.M., Kitchen-Goosen S.M., Rothbart S.B.5., Taslim C., Lessnick S.L., Peck A.S., Madaj Z.B., Bowman M.J., Grohar P.J.: Trabectedin inhibits EWS-FLI1 and evicts SWI/SNF from chromatin in a schedule dependent manner. Clinical Cancer Research 25(11): 3417-3429, Jun 2019.

Sissung T.M., Huang P.A., Hauke, R.J., McCrea, E.M., Peer, C.J., Barbier, R.H., Strope, J.D., Ley, A.M., Zhang, M., Hong, J.A., Venzon, D., Jackson, J.P., Brouwer, K.R., Grohar, P., Glod, J., Widemann, B.C., Heller, T., Schrump, D.S., Figg, W.D.: Severe hepatotoxicity of mithramycin therapy caused by altered expression of hepatocellular bile transporters. Molecular Pharmacology. Epub 2019 Jun 7. 96(2): 158-167, Jun 2019.

Gedminas J.M., Boguslawski E., Kitchen-Goosen S.M., Chasse M.H., Beddows I., Grohar P.J.: Lurbinectedin targets the EWS-WT1 transcription factor in desmoplastic small round cell tumor. Peer Reviewed Poster Presentation, Annual meeting of the American Society of Pediatric Hematology-Oncology, New Orleans, LA May 2019.

Bailey, K.M., Cost, C.R., Davis, I.J., Glade-Bender, J., Grohar, P.J., Houghton, P.J., Isakoff, M.S., Stewart, E., Laack, N., Yustein, J.T., Reed, D.R., Janeway, K.A., Gorlick, R., Lessnick, S.L., DuBois, S.G., Hingorani, P.: Emerging novel agents for patients with advanced Ewing sarcoma: a report from the Children’s Oncology Group (COG) new agents for Ewing sarcoma task force. F1000 Research Page: doi.org/10.12688, Apr 2019 Notes: epub ahead of print.

Flores, G., Kitchen-Goosen, S., Oswald, B.M., Boguslawski, E.A., Adams, M., Beddows, I., Madaj, Z.B., Grohar, P.J.: Mithramycin impedes EWS-FLI1 driven transcription by preventing target promoter clearance. Peer reviewed Poster Presentation at the Annual Meeting of the American Association for Cancer Research, Atlanta GA Apr 2019 Notes: AACR Minority Scholar-in-Training Award.

Chasse, M.H., Johnson, B.K., Boguslawski, E.A., Sorensen, K.M., Beddows, I., Madaj, Z.B., Foxa, G.E., Rybski, K.J., Kitchen-Goosen, S.M., Williams, B.O., Triche Jr., T.J., Grohar, P.J.: Mithramycin evicts SWI/SNF from chromatin to induce epigenetic reprogramming in rhabdoid tumor. Peer Reviewed Poster Presentation Invited for an Oral Presentation at the 18th Annual State of Michigan Pediatric Research Day, East Lansing MI Mar 2019.

Gedminas J.M., Boguslawski E., Kitchen-Goosen S.M., Chasse M.H., Beddows I., Grohar P.J.: Lurbinectedin inhibits the expression of EWS-WT1 in desmoplastic small round cell tumor. Peer Reviewed Poster Presentation Invited for an Oral Presentation at the 18th Annual State of Michigan Pediatric Research Day, East Lansing MI Mar 2019 Notes: Won Best Overall Poster Presentation.

back to top
Last updated: 05/22/2020
The Trustees of the University of Pennsylvania