Perelman School of Medicine at the University of Pennsylvania

Penn Institute for Immunology

Jan Joseph Melenhorst

faculty photo
Adjunct Associate Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
SPE South Tower, Rm. 9-105,
3400 Civic Center Boulevard, Blg. 421
Philadelphia, PA 19104-5156
Office: 215.573.6852
Lab: N/A
Education:
BSc (Biology, Geography, Associate Professor in Continuing Education)
Moller Institute, Netherlands, 1988.
MS (Medical Biology)
Nijmegen Katholic University, Netherlands, 1991.
PhD (Immunology)
Leiden University, Netherlands, 1998.
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Description of Clinical Expertise

As a translational immunologist my interest is in improving the potency and safety of adoptive immunogene therapy via correlative studies and product/process development. My translational interest also lies in streamlining the immunogene manufacturing process while maintaining or improving product potency.

Description of Other Expertise

Immunology of human allogeneic hematopoietic stem cell transplantation.

Description of Research Expertise

My expertise is in human T cell immunology and immunogene therapy, understanding and improving the anti-tumor efficacy of gene-engineered T cells for the treatment of cancers.

Selected Publications

Kristen B Long, Regina M Young, Alina C Boesteanu, Megan M Davis, J Joseph Melenhorst, Simon F Lacey, David A Degaramoda, Bruce L Levine, Joseph A Fraietta: CAR T cell therapy of non-hematopoietic malignancies - detours on the road to clinical success. Frontiers in Immunology 9: 2740, Dec 2018 Notes: No issue. Published online 2018 Dec 3. doi: 10.3389/fimmu.2018.02740.

Elise A. Chong, Jakub Svoboda, Sunita Dwivedy Nasta, Daniel J. Landsburg, Nicole Winchell, Ellen Napier, Anthony R. Mato, J. Joseph Melenhorst, Marco Ruella, Simon F Lacey, Carl H June and Stephen J. Schuster: Sequential Anti-CD19 Directed Chimeric Antigen Receptor Modified T-Cell Therapy (CART19) and PD-1 Blockade with Pembrolizumab in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphomas. Blood, American Society of Hematology Annual Meeting, San Diego, CA 132(Suppl 1), Nov 2018 Notes: Poster presentation.

Adam D. Cohen, J. Joseph Melenhorst, Alfred L. Garfall, Simon F Lacey, Megan Davis, Dan T. Vogl, Lifeng Tian, Vanessa Gonzalez, Iulian Pruteanu, Anne Marie Nelson, Gabriela Plesa, Adam Waxman, Regina M Young, Bruce L Levine, Carl H June, Edward A. Stadtmauer and Michael C. Milone: Predictors of T Cell Expansion and Clinical Responses Following B-Cell Maturation Antigen-Specific Chimeric Antigen Receptor T Cell Therapy (CART-BCMA) for Relapsed/Refractory Multiple Myeloma (MM). Blood, American Society of Hematology Annual Meeting, San Diego, CA 132(Suppl 1): 1974, Nov 2018 Notes: Poster presentation. doi: https://doi.org/10.1182/blood-2018-99-119665.

Ehren Dancy, Alfred L. Garfall, Adam D. Cohen, Joseph A Fraietta, Megan Davis, Bruce L Levine, Don L. Siegel, Edward A. Stadtmauer, Dan T. Vogl, Adam Waxman, Aaron P. Rapoport, Michael C. Milone, Carl H June and J. Joseph Melenhorst: Clinical Predictors of T Cell Fitness for CAR T Cell Manufacturing and Efficacy in Multiple Myeloma. Blood, American Society of Hematology Annual Meeting, San Diego, CA 132(Suppl 1): 1886, Nov 2018 Notes: Poster presentation. doi: https://doi.org/10.1182/blood-2018-99-115319.

Jaco A. C. Van Bruggen, Anne W. J. Martens, Joseph A Fraietta, Tom Hofland, Sanne Tonino, Eric Eldering, Mark-David Levin, Peter J. Siska, Sanne Endstra, Jeffrey C Rathmell, Carl H June, David L. Porter, J. Joseph Melenhorst, Gerritje J. W. van der Windt and Arnon P. Kater: Chronic Lymphocytic Leukemia Cells Impair Mitochondrial Fitness in CD8+ T Cells and Impede CAR T Cell Efficacy. Blood; presented at the American Society of Hematology Conference, San Diego, CA 132(Suppl 1): 235, Nov 2018 Notes: Poster presentation. doi: https://doi.org/10.1182/blood-2018-99-115911.

J. Joseph Melenhorst, David L. Porter, Lifeng Tian, Simon F. Lacey, Christopher Nobles, Joseph A. Fraietta, Noelle Frey, Irina Kulikovskaya, Minnal Gupta, Regina Young, David Ambrose, Donald Siegel, Frederic Bushman, Carl H June: Long-term Remission of CLL Sustained by Pauciclonal anti-CD19 Chimeric Antigen Receptor T (CTL019) Cell Clones. Blood, American Society of Hematology Annual Meeting, San Diego, CA 132(Suppl 1): 699, Nov 2018 Notes: Poster presentation. doi: https://doi.org/10.1182/blood-2018-99-117390

Luca Bernabei, Alfred L. Garfall, J. Joseph Melenhorst, Simon F Lacey, Edward A. Stadtmauer, Dan T. Vogl, Vanessa Gonzalez, Gabriela Plesa, Regina M Young, Adam Waxman, Bruce L Levine, Carl H June, Michael C. Milone and Adam D. Cohen: PD-1 Inhibitor Combinations As Salvage Therapy for Relapsed/Refractory Multiple Myeloma (MM) Patients Progressing after Bcma-Directed CAR T Cells. Blood, American Society of Hematology Annual Meeting, San Diego, CA 132(Suppl 1): 1973, Nov 2018 Notes: Poster presentation. doi: https://doi.org/10.1182/blood-2018-99-119514

Saar I. Gill, Vanessa Vides, Noelle V. Frey, Susan Metzger, Megan O'Brien, Elizabeth Hexner, Anthony R. Mato, Simon F Lacey, J. Joseph Melenhorst, Edward Pequignot, Whitney Lynn Gladney, Wei-Ting Hwang, Anne Lamontagne, Megan Davis, John C. Byrd, Stephen J. Schuster, Don L. Siegel, Randi E. Isaacs, Carl H June and David L. Porter: Prospective Clinical Trial of Anti-CD19 CAR T Cells in Combination with Ibrutinib for the Treatment of Chronic Lymphocytic Leukemia Shows a High Response Rate. Blood, American Society of Hematology Annual Meeting, San Diego, CA 132(Suppl 1): 298, Nov 2018 Notes: Poster presentation. doi: https://doi.org/10.1182/blood-2018-99-115418.

Christopher L Nobles, John K Everett, Shantan Reddy, Joseph A Fraietta, David L. Porter, Noelle V. Frey, Stephan A. Grupp, Don L. Siegel, Simon F Lacey, Carl H June, Frederic D Bushman and J. Joseph Melenhorst: Vector Integration and Efficacy of CD19-Directed CAR T Cell Therapy in Acute Lymphoblastic Leukemia (ALL) and Chronic Lymphocytic Leukemia (CLL). Blood, American Society of Hematology Annual Meeting, San Diego, CA 132(Suppl 1): 4548, Nov 2018 Notes: Poster presentation. doi: https://doi.org/10.1182/blood-2018-99-117034

Ruella M, Xu J, Barrett DM, Fraietta JA, Reich T, Ambrose DE, Klichinsky M, Shestova O, Patel PR, Kulikovskaya I, Nazimuddin F, Bhoj VG, Orlando E, Bitter H, Maude SL, Levine BL, Nobles CL, Bushman FD, Young RM, Scholler J, Gill SI, Fry TJ, June CH, Grupp SA, Lacey SF, Melenhorst JJ: Induction of Resistance to Chimeric Antigen Receptor (CAR) T Cell Therapy by Transduction of a Single Leukemic B Cell. Nature Med 24(10): 1499-1503, October 2018 Notes: See also the related News & Views piece by Sarwish Rafiq & Renier J. Brentjens in the same issue of Nature Med: "Tumors evading CARs—the chase is on", pp 1492 - 1493 .

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Last updated: 01/17/2019
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