Penn Institute for Immunology
Perelman School of Medicine at the University of Pennsylvania

Angela Haczku

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Research Associate Professor of Medicine
Department: Medicine

Contact information
Pulmonary, Critical Care and Sleep Medicine
UC Davis Health System
6510 Genome and Biomedical Sciences Facility
One Shields Avenue
Davis, CA 95616
Office: (530)-754-6932
Fax: (530)-752-8632
M.D. (General Medicine)
University Medical School Debrecen, Hungary, 1986.
Ph.D. (Immunology)
University of London, United Kingdom, 1997.
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Description of Research Expertise

The lung has an immunoprotective, hyporesponsive environment that helps prevent inappropriate immune and inflammatory responses to inhaled toxic, infectious or allergenic material. The long-term goal of my research is to unravel the the mechanisms that impair the innate and adaptive immune crosstalk during development of allergic and infectious inflammatory changes in the lung. To investigate T-cell related pathologies such as the allergic airway response my laboratory has established various in vitro and in vivo (rodent) model systems suitable to study pulmonary inflammation as well as the resulting changes in lung physiology. My laboratory is one of the few that study the importance of the pulmonary surfactant and in particular, the lung collectins, (SP-A and SP-D), in asthma and chronic obstructive pulmonary disease. Our observations support the novel concept that these lectin-like innate immune molecules play an essential protective regulatory role during inflammatory changes. Our studies are important because they may provide unique, novel therapeutical opportunities to control and manipulate the immune system in the lung.
Keywords: pulmonary medicine, allergy and clinical immunology, asthma, airway inflammation, lung physiology, cell biology, animal models, tissue culture, molecular biology, pulmonary surfactant, T cells, cytokines

Selected Publications

Adam VS, Crosariol M, Kumar S, Ge MQ, Czack SE, Roy S, Haczku A, Tretiakova A, Wilson JM, Limberis MP.: AAV9-mediated airway expression of antibody protects old and immunodeficient mice against influenza. Clin Vaccine Immunol Sep 2014.

Myint M, Limberis MP, Bell P, Somanathan S, Haczku A, Wilson JM, Diamond SL: In Vivo Evaluation of Adeno-Associated Virus Gene Transfer in Airways of Mice with Acute or Chronic Respiratory Infection. Hum Gene Ther Sep 2014.

Qi Yang, Moyar Q. Ge, Blerina Kokalari, Imre G. Redai, Xinxin Wang, Avinash Bhandoola, Angela Haczku : Group-2 Innate Lymphoid Cells Promote Air-Pollutant Induced Airway Inflammation and Hyperresponsiveness (AHR) J Allergy Clin Immunol 133(2S): AB232, Mar 2014.

Moyar Q. Ge, Monica Soni, Imre Redai, Blerina Kokalari, Angela Haczku, Zhilong Jiang: Antagonistic Effects Of Ozone (O3) Exposure and Glucocorticoid Treatment On Airway Hyperresponsiveness (AHR) and Surfactant Protein D (SP-D) Production In Mice. J Allergy Clin Immunol 133(2S): AB161, Mar 2014.

Vasiliki Gemou-Engesaeth, N. Laliotou, Chris J. Corrigan, George P. Chrousos, Angela Haczku: Serum Interleukin 13 (IL-13) and Surfactant Protein D (SP-D) Expression Is Differentially Associated With Disease Status In Pediatric Asthma Patients. J Allergy Clin Immunol 133(2S): AB148, Mar 2014.

Stephanie Kubala, Moyar Q. Ge, Imre Redai, Monica Soni, Bei Chen, Qi Yang, Avinash Bhandoola, Noam A. Cohen, Angela Haczku: Ozone Inhalation Induces Epithelial IL-33 and Thymic Stromal Lymphopoietin (TSLP) and Leads To Eosinophilic Airway Inflammation. J Allergy Clin Immunol 133(2S): AB145, Mar 2014.

Vasiliki Gemou-Engesaeth, Nikoletta Laliotou, Chris J Corrigan, George Chrousos, Angela Haczku: Expression of pulmonary surfactant protein D (SP-D) and interleukin 13 in the serum of atopic and non-atopic severe pediatric asthmatics: effects of glucocorticoid and sodium cromoglycate treatment. Clinical and Translational Allergy 4(S1): O3, Feb 2014.

Kim WK, Jain D, Sánchez MD, Koziol-White CJ, Matthews K, Ge MQ, Haczku A, Panettieri RA Jr, Frieman MB, López CB.: Deficiency of melanoma differentiation-associated protein 5 results in exacerbated chronic postviral lung inflammation. Am J Respir Crit Care Med 189(4): 437-48, Feb 2014.

M.Q. Ge, J. Hwang, I.G. Redai, B. Kokalari, L.R. Forbes, C.M.T. Bauer, C.S. Stevenson, A. Haczku: O3 Inhalation Attenuates The Effects Of Budesonide On Allergic Airway Inflammation And Surfactant Protein D (SP-D) Production In The Lung Of Balb/C Mice. Am J Respir Crit Care Med 187: A2658, May 2013.

Q. Yang, PhD, P. Cejas, B. Ducka, M.Q. Ge, I.G. Redai, A. Bhandoola, A. Haczku: Ozone Exposure Induced Increased IL-5 Production By Type 2 Innate Lymphoid Cells (ILC2) In Balb/c Mice. Am J Respir Crit Care Med 187: A2662, May 2013.

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Last updated: 10/16/2014
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