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Mark E. Mikkelsen, MD, MSCE, FCCM

Associate Professor of Medicine at the Hospital of the University of Pennsylvania
Associate Scholar, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine of the University of Pennsylvania
Chief, Section of Medical Critical Care, Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania Health System
Director, Medical Intensive Care Unit, Penn Presbyterian Medical Center
LDI Senior Fellow, Leonard Davis Institute, University of Pennsylvania
Department: Medicine

Contact information
Gates 05042
3400 Spruce Street
Hospital of the University of Pennsylvania
Philadelphia, PA 19104
Office: (215) 615-5416
Fax: (215) 614-0869
Lab: (267) 285-6602
BA (Political Science)
Colgate University, Hamilton, NY, 1996.
(Post-Baccalaureate Pre-Medical Degree Program)
Bryn Mawr College, Bryn Mawr, PA, 1997.
MD (Medical Degree)
University of Virginia School of Medicine, Charlottesville, VA, 2002.
MSCE (Clinical Epidemiology and Biostatistics)
University of Pennsylvania, Philadelphia, PA, 2008.
Post-Graduate Training
Internship, Internal Medicine, Hospital of the University of Pennsylvania, 2002-2003.
Residency, Internal Medicine, Hospital of the University of Pennsylvania, 2003-2005.
Post-Doctoral Fellow, Pulmonary, Allergy and Critical Care Division, Hospital of the University of Pennsylvania, 2005-2008.
LeadingSuccess Program, Office of Organization Effectiveness, Raymond and Ruth Perelman School of Medicine, University of Pennsylvania, 2015-2016.
American Board of Internal Medicine, Internal Medicine , 2005.
American Board of Internal Medicine, Pulmonary Disease, 2008.
American Board of Internal Medicine, Critical Care Medicine, 2009.
American Board of Internal Medicine, Internal Medicine Maintenance of Certification, 2015.
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Description of Research Expertise

Dr. Mikkelsen is the Chief of the Section of Medical Critical Care at Penn. He serves as Co-Chair of the UPHS Critical Care Committee and Medical Director of the Penn Presbyterian Medical Intensive Care Unit. Through these efforts, he supports the growth and development of a phenomenal group of multidisciplinary Penn providers who are collectively driven to educate the next generation of critical care clinicians, to deliver care of the highest quality to the critically ill, and to create and implement innovative science that advances the field of critical care medicine.

Research Program:
Through the lens of the patient and their family, Dr. Mikkelsen conducts patient-oriented research focused on sepsis, acute respiratory distress syndrome, and long-term outcomes in survivors of critical illness. He is passionate in his goal to improve the delivery of care to critically ill patients and to improve the lives of survivors of critical illness by understanding how critical illness impacts one's life and one's health trajectory.

Dr. Mikkelsen encourages colleagues, as well as survivors of critical illness and their loved ones, who are committed to improving the quality of care delivered to critically ill patients to contact him at Together, we can "be the difference."

Description of Clinical Expertise

Dr. Mikkelsen's philosophy for patient care is to ensure that exceptional, compassionate care is delivered to critically ill patients and their family members through outstanding, multi-disciplinary teamwork across the continuum of care, through the application of evidence-based care, and through systematic study to optimize our performance. Dr. Mikkelsen is an expert in critical care medicine, and the devastating syndromes of sepsis, acute respiratory distress syndrome, and post-intensive care syndrome specifically.

Dr. Mikkelsen partners with state and national government agencies to improve care delivery for the critically ill. He serves as Co-Chair of the Society of Critical Care Medicine's Thrive: Supporting Survivors of Critical Illness Initiative, Chair of the SCCM Internal Medicine Section, and was Co-Chair of the 2018 SCCM Congress in San Antonio, Texas. He also serves on the American Thoracic Society's Quality Improvement and Implementation Committee.

Selected Publications

Detsky, Kohn R, Delman AM, Buehler AE, Kent SA, Ciuffetelli IV, Mikkelsen ME, Turnbull AE, Harhay MO: Patients' perceptions and ICU clinicians predictions of quality of life following critical illness. J Crit Care 2018.

Maley JH, Mikkelsen ME: What happens to critically ill patients after they leave the ICU? Evidence-Based Practice of Critical Care, 3rd Edition. Elsevier, 2018 Notes: Chapter.

Burling S: Words that heal: ICU journals at Penn help patients and staff. Philadelphia Inquirer 2018 Notes: Published April 20, 2018: article available at

McPeake J, Mikkelsen ME: The evolution of post-intensive care syndrome. Crit Care Med 46(9): 1551-1552, 2018 Notes: Editorial.

Meyer N, Harhay MO, Small DS, Prescott HC, Bowles KH, Gaieski DF, Mikkelsen ME: Temporal trends in incidence, sepsis-related mortality, and hospital-based acute care after sepsis. Crit Care Med 46(3): 354-360, 2018.

Sepsis Alliance and Society of Critical Care Medicine: Life after sepsis Sepsis Alliance, SCCM and YouTube 2018 Notes: Co-designed informational video for sepsis survivors and caregivers.

Martin N, Pascual JL, Crowe D, Toevs C, Cereda MF, Mikkelsen M, Kaplan LJ: Comfort at the crossroads: service, therapy and emotional support animals in the ICU and at the end-of-life J Trauma Acute Care Surg 84(6): 978-984, 2018.

Kohn R, Harhay MO, Bayes B, Mikkelsen ME, Ratcliffe SJ, Halpern SD, Kerlin MP: Ward capacity strain: a novel predictor of of 30-day hospital readmissions J Gen Intern Med 2018 Notes: In press.

Gutsche JT, Miano TA, Vernick W, Raiten J, Bermudez C, Vallabjoysula P, Milewski K, Szeto W, Fall ML, Williams ML, Patel P, Mikkelsen ME, Chiu C, Ramakrishna H, Canon J, Augoustides JG: Does a mobile ECLS program reduce mortality for patients transported for ECLS therapy for severe acute respiratory failure? J Cardiothorac Vasc 32(3): 1137-1141, 2018.

Anderson BJ, Mikkelsen ME: A new direction: sleep and neuropsychological impairment after critical illness. Ann Am Thorac Soc 15(1): 114, 2018.

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Last updated: 12/09/2018
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