James D. Lewis, MD, MSCE
Professor of Medicine (Gastroenterology)
Department: Medicine
Graduate Group Affiliations
Contact information
University of Pennsylvania
Division of Gastroenterology
Center for Clinical Epidemiology and Biostatistics
423 Guardian Drive
720 Blockley Hall
Philadelphia, PA 19104-6021
Division of Gastroenterology
Center for Clinical Epidemiology and Biostatistics
423 Guardian Drive
720 Blockley Hall
Philadelphia, PA 19104-6021
Office: (215) 573-5137
Fax: (215) 573-0813
Fax: (215) 573-0813
Email:
lewisjd@mail.med.upenn.edu
lewisjd@mail.med.upenn.edu
Publications
Education:
BA (Interdisciplinary Studies)
University of Virginia, 1987.
MD
University of Pennsylvania, 1991.
MSCE (Clinical Epidemiology)
University of Pennsylvania, 1998.
BA (Interdisciplinary Studies)
University of Virginia, 1987.
MD
University of Pennsylvania, 1991.
MSCE (Clinical Epidemiology)
University of Pennsylvania, 1998.
Links
Search PubMed for articles
Penn Medicine Inflammatory Bowel Diseases Program
University of Pennsylvania Leonard Davis Institute of Health Economics
University of Pennsylvania Perelman School of Medicine Center for Clinical Epidemiology and Biostatistics
Permanent linkSearch PubMed for articles
Penn Medicine Inflammatory Bowel Diseases Program
University of Pennsylvania Leonard Davis Institute of Health Economics
University of Pennsylvania Perelman School of Medicine Center for Clinical Epidemiology and Biostatistics
Description of CCEB Expertise
Dr. James Lewis earned a BA in Interdisciplinary Studies from the University of Virginia in 1987. He received his MD degree from the University of Pennsylvania in 1991. He completed a residency in Internal Medicine and subsequently served as Chief Medical Resident at Yale University. Following his residency, Dr. Lewis simultaneously completed a fellowship in Gastroenterology and obtained a master’s degree in Clinical Epidemiology at the University of Pennsylvania. He joined the faculty at the University of Pennsylvania in 1998 and currently is Professor of Medicine and Epidemiology, Senior Scholar at the Center for Clinical Epidemiology and Biostatistics, Senior Fellow in the Leonard Davis Institute of Health Economics, Associate Director of the Penn Inflammatory Bowel Disease Program, and Director of the Gastroenterology and Hepatology Clinical Research Program.Dr. Lewis has been actively involved in research related to inflammatory bowel disease since 1996 and has published more than 200 scholarly articles. His research covers a broad range of topics, but primarily focuses on issues related to medication safety and optimizing medical therapies. Examples include a series of studies investigating whether patients treated with various medications for IBD are at increased risk for cancer, infections, neurologic diseases, and death, and whether such risks are warranted given the effectiveness of the therapy. Dr. Lewis is one of limited number of investigators to lead NIH funded clinical trials of novel therapeutic strategies for IBD. He has directed two clinical trials of rosiglitazone to treat ulcerative colitis and a trial of using biomarkers to adjust medical therapy for ulcerative colitis. He is currently on the steering committee of an NIH funded trial examining the efficacy of methotrexate for ulcerative colitis. In recent years, Dr. Lewis and his colleagues have begun to focus their research on how diet and the microorganisms that inhabit the human intestine may influence the course of IBD. Dr. Lewis hopes that this research may help to identify novel strategies for treating IBD that are not based on systemic immunosuppression.
Description of Content-based Expertise
Cancer Epidemiology, GI Epidemiology, PharmacoepidemiologySelected Publications
Lewis James D, Scott Frank I, Brensinger Colleen M, Roy Jason A, Osterman Mark T, Mamtani Ronac, Bewtra Meenakshi, Chen Lang, Yun Huifeng, Xie Fenglong, Curtis Jeffrey R: Increased Mortality Rates With Prolonged Corticosteroid Therapy When Compared With Antitumor Necrosis Factor-α-Directed Therapy for Inflammatory Bowel Disease. The American journal of gastroenterology 113(3): 405-417, Mar 2018.Khan Nabeel, Lee Helen, Trivedi Chinmay, Kavani Himanshu, Medvedeva Elina, Xie Dawei, Lewis James D, Yang Yu-Xiao: Mortality Associated With Development of Squamous Cell Cancer in Patients With Inflammatory Bowel Disease Receiving Treatment With Thiopurines. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 17(11): 2262-2268, Mar 2019.
Albenberg L, Brensinger C M, Wu Q, Gilroy E, Kappelman M D, Sandler R S, Lewis J D: A Diet Low in Red and Processed Meat Does Not Reduce Rate of Crohn's Disease Flares. Gastroenterology 157(1): 128-136.e5, Mar 2019.
Scott, F. I., Hans, A. K., Gerich, M. E., Fennimore, B., Mamtani, R., Vajravelu, R. K., Lewis, J. D.: Identification of the Most Effective Position for Ustekinumab in Treatment Algorithms for Crohn''s Disease. Clin Gastroenterol Hepatol 2020.
Scott, F. I., Luo, M., Shah, Y., Lasch, K., Vajravelu, R. K., Mamtani, R., Fennimore, B., Gerich, M. E., Lewis, J. D.: Identification of the Most Cost-effective Position of Vedolizumab Among the Available Biologic Drugs for the Treatment of Ulcerative Colitis. J Crohns Colitis 14(5): 575-587, Jun 2020.
Tanes C, Bittinger K, Gao Y, Friedman ES, Nessel L, Paladhi UR, Chau L, Panfen E, Fischbach MA, Braun J, Xavier RJ, Clish CB, Li H, Bushman FD, Lewis JD, Wu GD.: Role of dietary fiber in the recovery of the human gut microbiome and its metabolome. Cell Host Microbe ell Host Microbe: 394-407, Mar 2021.
Lewis JD, Sandler R, Brotherton C, Brensinger C, Li H, Kappelman MD, Daniel SG, Bittinger K, Albenberg L, Valentine JF, Hanson J, Suskind D, Meyer A, Compher CW, Bewtra M, Saxena A, Dobes A, Cohen B, Flynn AD, Fischer M, Saha S, Swaminath A, Yacyshyn B, Scherl E, Horst S, Curtis JR, Braly K, Nessel L, McCauley M, McKeever L, Herfarth H; DINE-CD Study Group.: A Randomized Trial Comparing the Specific Carbohydrate Diet to a Mediterranean Diet in Adults With Crohn's Disease. Gastroenterology May 2021.
Raffals LE, Saha S, Bewtra M, Norris C, Dobes A, Heller C, O'Charoen S, Fehlmann T, Sweeney S, Weaver A, Bishu S, Cross R, Dassopoulos T, Fischer M, Yarur A, Hudesman D, Parakkal D, Duerr R, Caldera F, Korzenik J, Pekow J, Wells K, Bohm M, Perera L, Kaur M, Ciorba M, Snapper S, Scoville EA, Dalal S, Wong U, Lewis JD.: The Development and Initial Findings of A Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease (SPARC IBD). Inflamm Bowel Dis 28: 192-199, Aug 2021.
Chassaing B, Compher C, Bonhomme B, Liu Q, Tian Y, Walters W, Nessel L, Delaroque C, Hao F, Gershuni V, Chau L, Ni J, Bewtra M, Albenberg L, Bretin A, McKeever L, Ley RE, Patterson AD, Wu GD, Gewirtz AT, Lewis JD.: Randomized controlled-feeding study of dietary emulsifier carboxymethylcellulose reveals detrimental impacts on the gut microbiota and metabolome. Gastroenterology Nov 2021.