Perelman School of Medicine at the University of Pennsylvania

McKay Orthopaedic Research Laboratory


Motomi Enomoto-Iwamoto

faculty photo
Research Associate Professor of Orthopaedic Surgery
Department: Orthopaedic Surgery

Contact information
The Children's Hospital of Philadelphia
Translational Research Program in Pediatric Orthopaedics
Division of Orthopaedic Surgery
Department of Surgery
3615 Civic Center Boulevard
Abramson Research Center 902A
Philadelphia, PA 19104
Office: 267-425-2071
Fax: 267-426-2215
Osaka University, 1983.
Ph.D. (Biochemistry)
Osaka University , 1987.
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Selected Publications

Shimono, K., Tung, W. E., Macolino, C., Chi, A. H., Didizian, J. H., Mundy, C., Chandraratna, R. A., Mishina, Y., Enomoto-Iwamoto, M., Pacifici, M., Iwamoto, M.: Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-gamma agonists. Nat Med 17(4): 454-60, 2011.

Yasuhara, R., Ohta, Y., Yuasa, T., Kondo, N., Hoang, T., Addya, S., Fortina, P., Pacifici, M., Iwamoto, M., Enomoto-Iwamoto, M.: Roles of beta-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells. Lab Invest 2011.

Zhang, X., Siclari, V. A., Lan, S., Zhu, J., Koyama, E., Dupuis, H. L., Enomoto-Iwamoto, M., Beier, F., Qin, L.: The critical role of the epidermal growth factor receptor in endochondral ossification. J Bone Miner Res 2011.

Mundy, C., Yasuda, T., Kinumatsu, T., Yamaguchi, Y., Iwamoto, M., Enomoto-Iwamoto, M., Koyama, E., Pacifici, M.: Synovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spine. Dev Biol 351(1): 70-81, 2011.

Kondo, N., Yuasa, T., Shimono, K., Tung, W., Okabe, T., Yasuhara, R., Pacifici, M., Zhang, Y., Iwamoto, M., Enomoto-Iwamoto, M.: Intervertebral Disc Development Is Regulated by Wnt/beta-catenin Signaling. Spine (Phila Pa 1976) 36(8): E513-E518, 2011.

Williams, J. A., Kane, M., Okabe, T., Enomoto-Iwamoto, M., Napoli, J. L., Pacifici, M., Iwamoto, M.: Endogenous retinoids in mammalian growth plate cartilage: analysis and roles in matrix homeostasis and turnover. J Biol Chem 285(47): 36674-81, 2010.

Yasuhara, R., Yuasa, T., Williams, J. A., Byers, S. W., Shah, S., Pacifici, M., Iwamoto, M., Enomoto-Iwamoto, M.: Wnt/beta-catenin and retinoic acid receptor signaling pathways interact to regulate chondrocyte function and matrix turnover. J Biol Chem 285(1): 317-27, 2010.

Yuasa, T., Kondo, N., Yasuhara, R., Shimono, K., Mackem, S., Pacifici, M., Iwamoto, M., Enomoto-Iwamoto, M.: Transient activation of Wnt/{beta}-catenin signaling induces abnormal growth plate closure and articular cartilage thickening in postnatal mice. Am J Pathol 175(5): 1993-2003, 2009.

Williams, J. A., Kondo, N., Okabe, T., Takeshita, N., Pilchak, D. M., Koyama, E., Ochiai, T., Jensen, D., Chu, M. L., Kane, M. A., Napoli, J. L., Enomoto-Iwamoto, M., Ghyselinck, N., Chambon, P., Pacifici, M., Iwamoto, M.: Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse. Dev Biol 328(2): 315-27, 2009.

Nagayama, M., Iwamoto, M., Hargett, A., Kamiya, N., Tamamura, Y., Young, B., Morrison, T., Takeuchi, H., Pacifici, M., Enomoto-Iwamoto, M., Koyama, E.: Wnt/beta-catenin signaling regulates cranial base development and growth. J Dent Res 87(3): 244-9, 2008.

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Last updated: 10/21/2011
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