Faculty

Susan K. Pierce, PhD

Department: Pathology and Laboratory Medicine

Contact information

Laboratory of Immunogenetics
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Twinbrook II
12441 Parklawn Drive, Room 200B, MSC 8180
Rockville, MD 208522

Education:
BS (Micriobiology)
Pennsylvania State University , 1971.
MS (Micriobiology)
Yale University, 1974.
PhD (Immunology)
University of Pennsylvania, 1976.

Permanent link

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Selected Publications

Waisberg Michael, Molina-Cruz Alvaro, Mizurini Daniella M, Gera Nidhi, Sousa Beatriz C, Ma Dongying, Leal Ana C, Gomes Tainá, Kotsyfakis Michalis, Ribeiro José M C, Lukszo Jan, Reiter Karine, Porcella Stephen F, Oliveira Carlo J, Monteiro Robson Q, Barillas-Mury Carolina, Pierce Susan K, Francischetti Ivo M B: Plasmodium falciparum infection induces expression of a mosquito salivary protein (Agaphelin) that targets neutrophil function and inhibits thrombosis without impairing hemostasis. PLoS pathogens 10(9): e1004338, Sep 2014.

Xu Yinsheng, Xu Liling, Zhao Meng, Xu ChenGuang, Fan Yilin, Pierce Susan K, Liu Wanli: No receptor stands alone: IgG B-cell receptor intrinsic and extrinsic mechanisms contribute to antibody memory. Cell research 24(6): 651-64, Jun 2014.

Wang Jing, Sohn Haewon, Sun Guangping, Milner Joshua D, Pierce Susan K: The autoinhibitory C-terminal SH2 domain of phospholipase C-γ2 stabilizes B cell receptor signalosome assembly. Science signaling 7(343): ra89, 2014.

Crompton Peter D, Moebius Jacqueline, Portugal Silvia, Waisberg Michael, Hart Geoffrey, Garver Lindsey S, Miller Louis H, Barillas-Mury Carolina, Pierce Susan K: Malaria immunity in man and mosquito: insights into unsolved mysteries of a deadly infectious disease. Annual review of immunology 32: 157-87, 2014.

Francischetti Ivo M B, Gordon Emile, Bizzarro Bruna, Gera Nidhi, Andrade Bruno B, Oliveira Fabiano, Ma Dongying, Assumpção Teresa C F, Ribeiro José M C, Pena Mirna, Qi Chen-Feng, Diouf Ababacar, Moretz Samuel E, Long Carole A, Ackerman Hans C, Pierce Susan K, Sá-Nunes Anderson, Waisberg Michael: Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria. PloS one 9(2): e87140, 2014.

Portugal Silvia, Pierce Susan K, Crompton Peter D: Young lives lost as B cells falter: what we are learning about antibody responses in malaria. Journal of immunology (Baltimore, Md. : 1950) 190(7): 3039-46, Apr 2013.

Illingworth Joseph, Butler Noah S, Roetynck Sophie, Mwacharo Jedida, Pierce Susan K, Bejon Philip, Crompton Peter D, Marsh Kevin, Ndungu Francis M: Chronic exposure to Plasmodium falciparum is associated with phenotypic evidence of B and T cell exhaustion. Journal of immunology (Baltimore, Md. : 1950) 190(3): 1038-47, Feb 2013.

Pierce Susan K, Liu Wanli: Encoding immunological memory in the initiation of B-cell receptor signaling. Cold Spring Harbor symposia on quantitative biology 78: 231-7, 2013.

Waisberg Michael, Lin Christina K, Huang Chiung-Yu, Pena Mirna, Orandle Marlene, Bolland Silvia, Pierce Susan K: The impact of genetic susceptibility to systemic lupus erythematosus on placental malaria in mice. PloS one 8(5): e62820, 2013.

Liu Xue Q, Stacey Katryn J, Horne-Debets Joshua M, Cridland Jasmyn A, Fischer Katja, Narum David, Mackay Fabienne, Pierce Susan K, Wykes Michelle N: Malaria infection alters the expression of B-cell activating factor resulting in diminished memory antibody responses and survival. European journal of immunology 42(12): 3291-301, Dec 2012.