Faculty

Nicholas P. Restifo, MD

Department: Pathology and Laboratory Medicine

Contact information

CRC Room 3-5762, National Cancer Institute, NIH
Bethesda, MD 20892

Office: (301) 496-4904

Education:
BA
Johns Hopkins University, Baltimore, MD , 1983.
MD
New York University School of Medicine, New York, NY , 1987.

Permanent link

> Perelman School of Medicine > Faculty > Details

Selected Publications

Moogk Duane, Zhong Shi, Yu Zhiya, Liadi Ivan, Rittase William, Fang Victoria, Dougherty Janna, Perez-Garcia Arianne, Osman Iman, Zhu Cheng, Varadarajan Navin, Restifo Nicholas P, Frey Alan B, Krogsgaard Michelle: Constitutive Lck Activity Drives Sensitivity Differences between CD8+ Memory T Cell Subsets. Journal of immunology (Baltimore, Md. : 1950) 197(2): 644-54, Jul 2016.

Crompton Joseph G, Narayanan Manikandan, Cuddapah Suresh, Roychoudhuri Rahul, Ji Yun, Yang Wenjing, Patel Shashank J, Sukumar Madhusudhanan, Palmer Douglas C, Peng Weiqun, Wang Ena, Marincola Francesco M, Klebanoff Christopher A, Zhao Keji, Tsang John S, Gattinoni Luca, Restifo Nicholas P: Lineage relationship of CD8(+) T cell subsets is revealed by progressive changes in the epigenetic landscape. Cellular & molecular immunology 13(4): 502-13, Jul 2016.

Goff Stephanie L, Dudley Mark E, Citrin Deborah E, Somerville Robert P, Wunderlich John R, Danforth David N, Zlott Daniel A, Yang James C, Sherry Richard M, Kammula Udai S, Klebanoff Christopher A, Hughes Marybeth S, Restifo Nicholas P, Langhan Michelle M, Shelton Thomas E, Lu Lily, Kwong Mei Li M, Ilyas Sadia, Klemen Nicholas D, Payabyab Eden C, Morton Kathleen E, Toomey Mary Ann, Steinberg Seth M, White Donald E, Rosenberg Steven A: Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 34(20): 2389-97, Jul 2016.

Roychoudhuri Rahul, Clever David, Li Peng, Wakabayashi Yoshiyuki, Quinn Kylie M, Klebanoff Christopher A, Ji Yun, Sukumar Madhusudhanan, Eil Robert L, Yu Zhiya, Spolski Rosanne, Palmer Douglas C, Pan Jenny H, Patel Shashank J, Macallan Derek C, Fabozzi Giulia, Shih Han-Yu, Kanno Yuka, Muto Akihiko, Zhu Jun, Gattinoni Luca, O'Shea John J, Okkenhaug Klaus, Igarashi Kazuhiko, Leonard Warren J, Restifo Nicholas P: BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers. Nature immunology 17(7): 851-60, Jul 2016.

Restifo Nicholas P, Smyth Mark J, Snyder Alexandra: Acquired resistance to immunotherapy and future challenges. Nature reviews. Cancer 16(2): 121-6, Feb 2016.

Klebanoff Christopher A, Rosenberg Steven A, Restifo Nicholas P: Prospects for gene-engineered T cell immunotherapy for solid cancers. Nature medicine 22(1): 26-36, Jan 2016.

Sukumar Madhusudhanan, Liu Jie, Mehta Gautam U, Patel Shashank J, Roychoudhuri Rahul, Crompton Joseph G, Klebanoff Christopher A, Ji Yun, Li Peng, Yu Zhiya, Whitehill Greg D, Clever David, Eil Robert L, Palmer Douglas C, Mitra Suman, Rao Mahadev, Keyvanfar Keyvan, Schrump David S, Wang Ena, Marincola Francesco M, Gattinoni Luca, Leonard Warren J, Muranski Pawel, Finkel Toren, Restifo Nicholas P: Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy. Cell metabolism 23(1): 63-76, Jan 2016.

Nelson Michelle H, Bowers Jacob S, Bailey Stefanie R, Diven Marshall A, Fugle Caroline W, Kaiser Andrew D M, Wrzesinski Claudia, Liu Bei, Restifo Nicholas P, Paulos Chrystal M: Toll-like receptor agonist therapy can profoundly augment the antitumor activity of adoptively transferred CD8(+) T cells without host preconditioning. Journal for immunotherapy of cancer 4: 6, 2016.

Palmer Douglas C, Guittard Geoffrey C, Franco Zulmarie, Crompton Joseph G, Eil Robert L, Patel Shashank J, Ji Yun, Van Panhuys Nicholas, Klebanoff Christopher A, Sukumar Madhusudhanan, Clever David, Chichura Anna, Roychoudhuri Rahul, Varma Rajat, Wang Ena, Gattinoni Luca, Marincola Francesco M, Balagopalan Lakshmi, Samelson Lawrence E, Restifo Nicholas P: Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance. The Journal of experimental medicine 212(12): 2095-113, Nov 2015.

Rodriguez-Peña A B, Gomez-Rodriguez J, Kortum R L, Palmer D C, Yu Z, Guittard G C, Wohlfert E A, Silver P B, Misplon J A, Sommers C L, Feigenbaum L, Epstein S L, Caspi R R, Belkaid Y, Restifo N P, Samelson L E, Balagopalan L: Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules. Gene therapy 22(10): 781-92, Oct 2015.