Issam A. Mardini, MD, PhD

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Associate Professor of Clinical Anesthesiology and Critical Care
Attending Physician, Hospital of the University of Pennsylvania
Attending Physician, Penn Presbyterian Medical Center
Department: Anesthesiology and Critical Care

Contact information
Department of Anesthesiology and Critical Care
Penn Presbyterian Medical Center
Philadelphia, PA 19104
Office: (610) 416-4145
University of Damascus, Damascus, Syria, 1978.
Ph.D. (Physiology & Pharmacology)
University of South Dakota, 1985.
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> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

Anti-inflammatory drugs, cyclooxygenases ,prostaglandins, mechanisms of pain

Description of Clinical Expertise

Acute pain management, perioperative pain control, chronic pain medicine, nerve blocks and regional anesthesia, injection/ablation for chronic pain, anesthesia for orthopedic and gynecological surgery,anesthesia for urological surgery, anticoagulation agents in the perioperative period and their interactions with regional anesthesia.Anesthesia for EP procedures, GI procedures and Bronchoscopy

Description of Other Expertise

Educational development for professional students and graduate/postgraduate physicians

Selected Publications

Aksoy MO, Mardini IA, Yang Y, Bin W, Zhou S, Kelsen SG: Glucocorticoid effects on the beta-adrenergic receptor-adenylyl cyclase system of human airway epithelium. J Allergy Clin Immunol 109(3): 491-7, Mar 2002.

McAdam BF, Mardini IA, Habib A, Burke A, Lawson JA, Kapoor S, FitzGerald GA: Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation. J Clin Invest 105(10): 1473-82, May 2000.

McAdam BF, Catella-Lawson F, Mardini IA, Kapoor S, Lawson JA, FitzGerald GA: Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2. Proc Natl Acad Sci U S A 96(1): 272-7, Jan 1999.

Kelsen SG, Higgins NC, Zhou S, Mardini IA, Benovic JL: Expression and function of the beta-adrenergic receptor coupled-adenylyl cyclase system on human airway epithelial cells. Am J Respir Crit Care Med 152(6 Pt 1): 1774-83, Dec 1995.

Kelsen SG, Zhou S, Anakwe O, Mardini IA, Higgins N, Benovic JL: Expression of the beta-adrenergic receptor-adenylyl cyclase system in basal and columnar airway epithelial cells. Am J Physiol 267(4 Pt 1): L456-63, Oct 1994.

Mardini IA, Higgins NC, Zhou S, Benovic JL, Kelsen SG: Functional behavior of the beta-adrenergic receptor-adenylyl cyclase system in rabbit airway epithelium. Am J Respir Cell Mol Biol 11(3): 287-95, Sep 1994.

Kelsen SG, Sexauer WP, Mardini IA, Criner GJ: The comparative effects of elastase-induced emphysema on costal and crural diaphragm and parasternal intercostal muscle contractility. Am J Respir Crit Care Med 149(1): 168-73, Jan 1994.

Kelsen SG, Bao S, Thomas AJ, Mardini IA, Criner GJ: Structure of parasternal intercostal muscles in the adult hamster: topographic effects. J Appl Physiol (1985) 75(3): 1150-4, Sep 1993.

Kelsen SG, Mardini IA, Zhou S, Benovic JL, Higgins NC: A technique to harvest viable tracheobronchial epithelial cells from living human donors. Am J Respir Cell Mol Biol 7(1): 66-72, Jul 1992.

Mardini IA, Zhou S, Blank K, Kelsen SG: Eicosanoids PGE2 and PGF2 alpha enhance the attachment of rabbit tracheal epithelial cells to a collagen substrate. Chest 101(3 Suppl): 25S, Mar 1992.

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Last updated: 06/16/2022
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