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Sergei V. Zaytsev, Ph.D.

Sergei V. Zaytsev, Ph.D.

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Research Assistant Professor of Pharmacology
Department: Pharmacology

Contact information
Institute for Translational Medicine and Therapeutics
University of Pennsylvania School of Medicine
421 Curie Boulevard
Philadelphia, PA 19104-6160
Office: (215) 740-8970
Fax: (215) 898-0868
M.S. (Physics/Biophysics)
St. Petersburg State University, Russia, 1992.
Ph.D. (Biology)
Institute of Cytology, Russian Academy of Sciences, 2000.
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Selected Publications

Carnemolla R, Greineder CF, Chacko AM, Patel KR, Ding BS, Zaitsev S, Esmon CT, Muzykantov VR.: Platelet endothelial cell adhesion molecule targeted oxidant-resistant mutant thrombomodulin fusion protein with enhanced potency in vitro and in vivo. J Pharmacol Exp Ther. 347(2): 339-45, Nov 2013.

Carnemolla R, Patel KR, Zaitsev S, Cines DB, Esmon CT, Muzykantov VR: Quantative analysis of thrombomodulin-mediated conversion of protein C to APC: Translation from in vitro to in vivo. . J Immunol Methods PMID 22750541, Jun 27 2012.

Zaitsev S, Kowalska MA, Neyman M, Carnemolla R, Tliba S, Ding BS, Stonestrom A, Spitzer D, Atkinson JP, Poncz M, Cines DB, Esmon CT, Muzykantov VR.: Targeting recombinant thombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis. Blood 119(20): 4779-85, May 17 2012.

Pisapia JM, Xu X, Kelly J, Yeung J, Carrion G, Tong H, Meghan S, El-Falaky OM, Grady MS, Smith DH, Zaitsev S, Muzykantov VR, Stiefel MF, Stein SC.: Microthrombosis after Experimental Subarachnoid Hemorrhage: Time Course and Effect of Red Blood Cell-Bound Thrombin-Activated Pro-Urokinase and Clazosentan Exp Neurol. 233(1): 357-63, Jan 2012.

Armstead WM, Ganguly K, Riley J, Zaitsev S, Cines DB, Higazi AA, Muzykantov VR.: RBC-coupled tPA prevents whereas tPA aggravates JNK MAPK-mediated impairment of ATP- and Ca-sensitive K channel-mediated cerebrovasodilation after cerebral photothrombosis. Transl. Stroke Res. 3: 114-121, 2012.

Armstead WM, Ganguly K, Riley J, Kiessling JW, Cines DB, Higazi AA, Zaitsev S, Muzykantov VR: Red blood cell-coupled tissue plasminogen activator prevents impairment of cerebral vasodilatory responses through inhibition of c-Jun-N-terminal kinase and potentiation of p38 mitogen-activated protein kinase after cerebral photothrombosis in the newborn pig. Pediatr Crit Care Med 12(6): e369-75, Nov 2011.

Shuvaev VV, Ilies MA, Simone E, Zaitsev S, Kim Y, Cai S, Mahmud A, Dziubla T, Muro S, Discher DE, Muzykantov VR.: Endothelial targeting of antibody-decorated polymeric filomicelles. ACS Nano 5(9): 6991-9, Sep 27 2011.

Gersh KC, Zaitsev S, Cines DB, Muzykantov V, Weisel JW.: Flow-dependent channel formation in clots by an erythrocyte-bound fibrinolytic agent. Blood 117((18)): 4964-7, May 5 2011.

Gersh KC, Zaitsev S, Muzykantov V, Cines DB, Weisel JW: The spatial dynamics of fibrin clot dissolution catalyzed by erythrocyte-bound vs. free fibrinolytics. J Thromb Haemost 8(5): 1066-1074, 2010.

Zaitsev S, Spitzer D, Murciano JC, Ding BS, Tliba S, Kowalska MA, Marcos-Contreras OA, Kuo A, Stepanova V, Atkinson JP, Poncz M, Cines DB, Muzykantov VR: Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation. Blood 115(25): 5241-5248, 2010.

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Last updated: 10/08/2014
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