Hongtao Zhang, Ph.D.

faculty photo
Research Associate Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
Department of Pathology / Lab Medicine
252 John Morgan Bldg
3620 Hamilton Walk
Philadelphia, PA 19104
Office: 215-573-9256
Fax: 215-898-2401
B.S. (Biochemistry)
Beijing University, China, 1991.
M.S. (Molecular Biology)
Beijing University, China, 1994.
Ph.D (Pharmacology)
University of Pennsylvania, 1998.
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Description of Research Expertise

-Targeted therapies for ErbB and related receptors (EGFR, HER2)
-Inhibitors for TNF family of receptors: TNFR, RANK etc.
-Protein engineering for antibody -like proteins
-Biomarkers to facilitate treatment for Breast cancer and Melanoma

Selected Publications

Kumar, S. M., Liu, S., Lu, H., Zhang, H., Zhang, P. J., Gimotty, P. A., Guerra, M., Guo, W., Xu, X. : Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiation. Oncogene 31(47): 4898-911, Nov 2012 Notes: doi: 10.1038/onc.2011.656. Epub 2012 Jan 30.

Song, X., Li, B., Xiao, Y., Chen, C., Wang, Q., Liu, Y., Berezov, A., Xu, C., Gao, Y., Li, Z., Wu, S., Cai, Z., Zhang, H., Karger, B., Hancock, W.H., Wells, A. D., Zhou, Z. and Greene, M.I. : Structural and Biological features of Insights of FOXP3 Dimerization Relevent to Regulatory T Cell Function. Coiled Coil Subdomain in Oligomerization-Dependent Immune Modulation. Cell reports 1(6): 665-75, Jun 2012 Notes: doi: 10.1016/j.celrep.2012.04.012. Epub 2012 Jun 15.

Tchou J, Wang LC, Selven B, Zhang H, Conejo-Garcia J, Borghaei H, Kalos M, Vondeheide RH, Albelda SM, June CH, Zhang PJ. : Mesothelin, a novel immunotherapy target for triple negative breast cancer. Breast Cancer Res Treat. 133(2): 799-804, June 2012 Notes: doi: 10.1007/s10549-012-2018-4. Epub 2012 Mar 15.

Lam, L., McAndrew, N., Yee, M., Fu, T., Tchou, J.C., and Zhang, H.: Challenges in the clinical utility of the serum test for HER2 ECD. Biochimica et biophysica acta 1826(1): 199-208, Aug 2012 Notes: doi: 10.1016/j.bbcan.2012.03.012. Epub 2012 Apr 3.

Zhou, Z., Du, X., Cai, Z., Song, X., Zhang, H., Mizuno, T., Suzuki, E., Yee, M. R., Berezov, A., Murali, R., Wu, S. L., Karger, B. L., Greene, M. I., Wang, Q.: Structure of Sad1-UNC84 Homology (SUN) Domain Defines Features of Molecular Bridge in Nuclear Envelope. The Journal of biological chemistry 287(8): 5317-26, Feb 2012.

Zhang, H., Xiao, Y., Zhu, Z., Li, B., Greene, M. I.: Immune regulation by histone deacetylases: a focus on the alteration of FOXP3 activity. Immunol Cell Biol 90(1): 95-100, Jan 2012 Notes: doi: 10.1038/icb.2011.101. Epub 2011 Nov 29.

Zhou, H., Zha, Z., Liu, Y., Zhang, H., Zhu, J., Hu, S., Cheng, L., Niu, L., Greene, M.I. , Teng, M. and Liu, J. : Structural insights into the down-regulation of overexpressed p185her2/neu of transformed cells by the antibody chA21. JBC 286(36): 31676-83, Sept 2011 Notes: doi: 10.1074/jbc.M111.235184. Epub 2011 Jun 16.

Fu, W., Madan, E., Yee, M., Zhang, H.: Progress of molecular targeted therapies for prostate cancers. Biochimica et biophysica acta 1825(2): 140-152, Apr 2011 Notes: doi: 10.1016/j.bbcan.2011.11.003. Epub 2011 Nov 29.

Zhang H, Fu T, McGettigan S, Kumar S, Liu S, Speicher D, Schuchter L, and Xu X. : IL8 and Cathepsin B as Melanoma Serum Biomarkers. Int j Mol Sci 12(3): 1505-1518, June 2011 Notes: doi:10.3390/ijms12031505. Epub 2011 Feb 25.

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Last updated: 01/15/2021
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