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Yugong Ho, Ph.D.

Yugong Ho, Ph.D.

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Research Assistant Professor of Genetics
Department: Genetics

Contact information
Department of Genetics
University of Pennsylvania School of Medicine
545 Clinical Research Building
415 Curie Boulevard
Philadelphia, PA 19104-6145
Office: 215-573-1886
Lab: 215-898-0391
Education:
B.S. (Biology)
Jinan University, Guangzhou, P.R. China, 1983.
M.A. (Biology)
Temple University, Philadelphia, PA, 1992.
Ph.D. (Biology)
Temple University, Philadelphia, PA, 1999.
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Selected Publications

Yugong Ho*, Nancy E. Cooke, and Stephen A. Liebhaber : An auto-regulatory pathway establishes the definitive chromatin conformation at the Pit-1 locus Molecular and Cellular Biology In press, 2015 Notes: Corresponding author.

Harms, M. J., Lim, H., Ho, Y., Shapira, S. N., Ishibashi, J., Rajakumari, S., Steger, D. J., Lazar, M. A., Won, K., and Seale, P.: PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program. Genes and Development 29(3): 298-307, 2015.

Yashiro-Ohtani Y, Wang H, Zang C, Arnett KL, Bailis W, Ho Y, Knoechel B, Lanauze C, Louis L, Forsyth KS, Chen S, Chung Y, Schug J, Blobel GA, Liebhaber SA, Bernstein BE, Blacklow SC, Liu XS, Aster JC, Pear WS.: Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia. Proc. Natl. Acad. Sci. U S A. 111(46): E4946-53, 2014.

Ho, Y.,* Shewchuk, B. M., Liebhaber, S. A., Cooke, N. E.: Distinct chromatin configurations regulate the initiation and the maintenance of hGH gene expression. Molecular and cellular biology 33(9): 1723-34, 2013 Notes: *Corresponding author.

Fleetwood, M. R., Ho, Y., Cooke, N. E., Liebhaber, S. A.: DNase I hypersensitive site II of the human growth hormone locus control region mediates an essential and distinct long-range enhancer function. The Journal of biological chemistry 287(30): 25454-65, 2012.

Ho, Y.,* Liebhaber, S. A., Cooke, N. E.: The role of the hGH locus control region in somatotrope restriction of hGH-N gene expression. Molecular endocrinology 25(5): 877-84, 2011 Notes: *Corresponding author.

Sizova, D., Ho, Y., Cooke, N. E., Liebhaber, S. A.: Research resource: T-antigen transformation of pituitary cells captures three novel cell lines in the Pit-1 lineage. Molecular endocrinology 24(11): 2232-40, 2010.

Ho, Y., Tadevosyan, A., Liebhaber, S. A., Cooke, N. E.: The juxtaposition of a promoter with a locus control region transcriptional domain activates gene expression. EMBO Rep 9(9): 891-8, 2008.

Ho, Y., Elefant, F., Liebhaber, S. A., Cooke, N. E.: Locus control region transcription plays an active role in long-range gene activation. Mol Cell 23(3): 365-75, 2006.

Ho, Y., Elefant, F., Cooke, N., Liebhaber, S.: A defined locus control region determinant links chromatin domain acetylation with long-range gene activation. Mol Cell 9(2): 291-302, 2002.

Shewchuk, B. M., Ho, Y., Liebhaber, S. A., Cooke, N. E.: A single base difference between Pit-1 binding sites at the hGH promoter and locus control region specifies distinct Pit-1 conformations and functions. Mol Cell Biol 26(17): 6535-46, 2006.

Ho, Y., Liebhaber, S. A., Cooke, N. E.: Activation of the human GH gene cluster: roles for targeted chromatin modification. Trends Endocrinol Metab 15(1): 40-5, 2004.

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Last updated: 04/14/2015
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