Richard L. Dunbar, M.D.

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Adjunct Assistant Professor of Medicine
Department: Medicine

Contact information
3 Oak Terrace
Voorhees, NJ 08043
Education:
B.A. (Environmental Sciences)
University of Virginia, Charlottesville, VA, 1992.
M.D. (Medicine)
Medical College of Virginia, Richmond, VA, 1997.
M.S. (Translational Research)
University of Pennsylvania School of Medicine, Philadelphia, PA, 2008.
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Description of Research Expertise

Dr. Dunbar is interested in atherogenic dyslipidemia and its treatment, and has particular expertise in the mechanism of action and adverse effects of triglyceride-lowering drugs. He has worked with a variety of several novel triglyceride-lowering compounds, including niacin and novel niacin mimetics, fibrates and novel fibrates, novel fish oils, and a host of other emerging drugs: DGAT-1 inhibitor, MTP inhibitor, AngPTL3 inhibitor, ApoC3 inhibitor, a glitazar, and perhaps most uniquely, lipoprotein lipase gene replacement therapy. He also employs a variety of provoked outcomes in his research, such as oral fat tolerance testing with/without radiolabeled fat to trace chylomicrons, stable isotope lipoprotein kinetics, euglycemic-hyperinsulinemic clamp, FSIVGTT, indocyanine green to test hepatic function, other nutrient challenges, and a variety of modalities to measure niacin-associated skin toxicity. A common theme of these is the concept that perturbing a system reveals more as an outcome than the steady state. His research focuses on translating pre-clinical findings into humans, and indeed works exclusively on patient-oriented, clinical research.

Selected Publications

Dunbar RL, Copland C, Jiao L, Wang R, Wong K, Millar JS, Escobar M, Siri-Tarino P, Juliano RA: Icosapent Ethyl Mitigates Dyslipidemia by Both Slowing Triglyceride-Rich Lipoprotein Production and Hastening LDL Clearance [Poster Presentation] J Clin Lip December 2020 Notes: Presentation to the National Lipid Association 2020 Scientific Sessions.

Bhatt DL, Miller M, Steg G, Brinton EA, Jacobson TA, Ketchum SB, Juliano RA, Jiao L, Doyle RT, Copland C, Dunbar RL, Granowitz C, Martens FM, Budoff M, Nelson JR, Mason RP, Libby P, Ridker P, Tardif J-C, Ballantyne CM: EPA Levels and Cardiovascular Outcomes in the Reduction of Cardiovascular Events with Icosapent Ethyl–Intervention Trial [Poster Presentation] J Clin Lip December 2020 Notes: Presentation to the National Lipid Association 2020 Scientific Sessions.

Ueda M, Wolska A, Sampson M, Rader DJ, Dunbar RL, Remaley AT: Novel Approaches to Detect Outlier Triglyceride Levels: Identification of Pseudo-Hypertriglyceridemia and Glycerol Kinase Deficiency [Poster Presentation] J Clin Lip December 2020 Notes: Presentation to the National Lipid Association 2020 Scientific Sessions.

Dunbar RL, Copland C, Jiao L, Wang R, Wong K, Millar JS, Escobar M, Siri-Tarino P, Juliano RA: Comparing Eicosapentaenoic Acid Between Plasma and Serum From the VALUE Study: A Randomized, Controlled Clinical Trial [Poster Presentation] J Clin Lip December 2020 Notes: Presentation to the National Lipid Association 2020 Scientific Sessions.

Dunbar RL, Copland C, Jiao L, Wang R, Wong K, Millar JS, Escobar M, Siri-Tarino P, Juliano RA: Icosapent Ethyl Mitigates Dyslipidemia by Both Slowing Triglyceride-Rich Lipoprotein Production and Hastening LDL Clearance [Poster Presentation] ATVB May 2020 Notes: Presentation to Vascular Discovery: From Genes to Medicine (nee ATVB), May 5-7, 2020.

Ueda M, Goel H, Lalic D, Pollan P, Nathanson GA, Hoque J, Escobar M, Rader DJ, Dunbar RL: Contrasting Postprandial Triglyceride Response of Two Niacin Formulations and Regimens To Modify Coronary Heart Disease Risk [Poster Presentation] ATVB May 2020 Notes: Presentation to Vascular Discovery: From Genes to Medicine (nee ATVB), May 5-7, 2020.

Dunbar RL, Gaudet D, Davidson M, Rensfeldt M, Yang H, Nilsson C, Kvarnstrom M, Oscarsson J: Omega-3 Fatty Acid Exposure with a Low-Fat Diet in Patients with Past Hypertriglyceridemia-Induced Acute Pancreatitis: An Exploratory, Randomized, Open-Label Crossover Study. Lipids Health Dis 19(1): 117, May 2020.

Ueda M, Wolska A, Burke FM, Sampson M, Rader DJ, Dunbar RL, Remaley AT: A Rare Case of Laboratory Hypertriglyceridemia: Glycerol Kinase Deficiency [Poster Presentation] J Endo Soc April 2020 Notes: Presentation to the Endocrine Society 2020 Scientific Sessions.

Rastogi A, Dunbar RL, Thacker HP, Bhatt J, Parmar K, Parmar D: Abrogation of Postprandial Triglyceridemia with Dual PPAR α/γ Agonist in Type 2 Diabetes Mellitus: A Randomized, Placebo-Controlled Study. Acta Diabetologica February 2020.

Ueda M, Wolska A, Burke F, Escobar M, Walters L, Lalic D, Hegele RA, Remaley A, Rader DJ, Dunbar RL: Experimental Therapeutics for Challenging Clinical Care of a Patient with an Extremely Rare Homozygous APOC2 Mutation. Case Reports in Endocrinology 2020 Notes: Accepted for Publication 24 Dec 19.

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Last updated: 12/17/2020
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