Seung-Cheol Lee, Ph.D.

faculty photo
Research Assistant Professor of Radiology
Department: Radiology

Contact information
B6 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104
Office: 215-746-7387
Fax: 215- 573-2113
B.S. (Physics)
Korea Advanced Institute of Science and Technology, 1993.
M.S. (Solid State Physics)
Korea Advanced Institute of Science and Technology, 1995.
Ph.D. (Solid State Physics)
Korea Advanced Institute of Science and Technology, 2001.
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Description of Research Expertise

MRI and MRS of cancer cells, animal models and human patients
Prediction and early detection of therapeutic response in non-Hodgkin's lymphoma

Selected Publications

Nath, K., Roman, J., Nelson, D.S., Guo, L., Lee, S.C., Orlovskiy, S., Muriuki, K., Heitjan, D.F., Pickup, S., Leeper, D., Blair, I.A., Putt, M.E., Glickson, J.D. : Effect of differences in metabolic activity of melanoma models on response to lonidamine plus doxorubicin. Scientific Reports 8(1): 14654, October 2018.

Nath, K., Nelson, D.S., Roman, J., Putt, M.E., Lee, S.C., Leeper, D.B., Glickson, J.D.: Effect of lonidamine systemic therapy of DB-1 human melanoma xenografts with Temozolomide. Anticancer Research 37(7): 3413-3421, July 2017.

Nath, K., Guo, L., Nancolas, B., Nelson, D.S., Shestov, A.A., Lee, S.C., Roman, J., Zhou, R., Leeper, D.B., Halestrap, A.P., Blair, I.A., Glickson, J.D.: Mechanism of antineoplastic activity of lonidamine. Biochim Biophys Acta 1866(2): 151-162, August 2016.

Shestov, A.A., Lee, S.C., Nath, K., Guo, L., Nelson, D.S., Roman, J.C., Leeper, D.B., Wasik, M.A., Blair, I., Glickson, J.D.: 13C MRS and LC-MS flux analysis of tumor intermediary metabolism. Frontiers in Oncology 6: 135, June 2016.

Shestov AA, Mancuso A, Lee SC, Guo L, Nelson DS, Roman JC, Henry PG, Leeper DB, Blair IA, Glickson JD.: Bonded cumomer analysis of human melanoma metabolism monitored by 13C NMR spectroscopy of perfused tumor cells. Journal of Biological Chemistry 291(10): 5157-5171, March 2016.

Arias-Mendoza, F., Payne, G.S., Zakian, K., Stubbs, M., O'Conner, O.A., Mojahed, H., Smith, M.R., Schwarz, A.J., Shukla-Dave, A., Howe, F., Poptani, H., Lee, S.C., Pettengel ,R., Schuster, S.J., Cunningham, D., Heerschap, A., Glickson, J.D., Griffiths, J.R., Koutcher, J.A., Leach, M.O., Brown, T.R. : Noninvasive phosphorus magnetic resonance spectroscopic imaging predicts outcome to first-line chemotherapy in newly diagnosed patients with diffuse large B-Cell lymphoma. Academic Radiology 20(9): 1122-1129, September 2013.

Xu, H.N., Zhao, H., MIR, T.A., Lee, S.C., Feng, M., Choe, R., Glickson, J.D., Li, L.Z.: CHOP therapy induced mitochondrial redox state alteration in non-Hodgkin's lymphoma xenografts. Journal of Innovative Optical Health Sciences 6(2): 1350011, April 2013.

Nath, K., Nelson, D.S., Ho, A., Lee, S.C., Darpolar, M., Pickup, S., Zhou, R., Heitjan, D.F., Leeper, D.B., Glickson, J.D.: 31P and 1H MRS of DB-1 melanoma xenografts: lonidamine selectively decreases tumor intracellular pH and energy status and sensitizes tumors to melphalan. NMR in Biomedicine 26(1): 98-105, January 2013.

Lee, S.C., Marzec, M., Liu, X., Wehrli, S., Kantekure, K., Ragunath, P.N., Nelson, D.S., Delikatny, E.J., Glickson, J.D., Wasik, M.A.: Decreased lactate concentration and glycolytic enzyme expression reflect inhibition of mTOR signal transduction pathway in B-cell lymphoma. NMR in Biomedicine 26(1): 106-114, January 2013.

Xu, H.N., Mir, T.A., Lee, S.C., Feng, M., Farhad, N., Choe, R., Glickson, J.D., Li, L.Z.: Mapping the redox state of CHOP-treated non-Hodgkin's lymphoma xenografts in mice. Advances in Experimental Medicine and Biology 789: 243-249, January 2013.

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Last updated: 12/01/2018
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