Zheng Cai, Ph.D.

faculty photo
Research Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
252 John Morgan Building
36th ST and Hamiltion walk
Philadelphia, PA 19104
Fax: 215-898-2401
Lab: 215-898-2870
B.S. (Biology)
University of Sci. and Tech. of China , 1997.
Ph.D. (Biochemistry and Molecular Biology)
University of Sci. and Tech. of China , 2004.
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Description of Research Expertise

-protein production(E.Coli, Insect, Mammalian)
-protein structure determination (NMR/Crystallization)
-protein/protein, protein/ligand interaction, ITC, SPR, co-crytallization
-structure-based drug design and development.

-Kinase inhibitors, small molecule drugs
-antibody mimetics, peptide drugs

-Targeted therapies for ErbB and related receptors.
-Breast cancer, lung cancer, Colon Cancer
-Heparin-induced thrombocytopenia

Selected Publications

Cai Z, Zhu Z, Greene MI, Cines DB: Atomic features of an autoantigen in heparin-induced thrombocytopenia (HIT). Autoimmun Rev 15(7): 752-5, Jul 2016.

Cai Z, Yarovoi SV, Zhu Z, Rauova L, Hayes V, Lebedeva T, Liu Q, Poncz M, Arepally G, Cines DB*, Greene MI*: Atomic description of the immune complex involved in heparin-induced thrombocytopenia. Nature Communications Page: 6:8277, Sep 22 2015 Notes: * Co-first author.

Cai Z, Yarovoi SV, Zhu Z, Rauova L, Lebedeva T, Liu Q, Poncz M, Arepally G, Cines DB*, and Greene MI*. : Atomic Level Description of the Immune Complex That Causes Heparin-Induced Thrombocytopenia (HIT). 56th ASH annual meeting, San Francisco, CA Dec 2014 Notes: * Co-first author.

Liu Q, Guo Y, Chang Y, Cai Z, Assur Z, Mancia F, Greene MI, Hendrickson WA.: Multi-crystal native SAD analysis at 6 keV. Acta Crystallogr D Biol Crystallogr 70(Pt 10): 2544-57, Oct 2014.

Cai Z, Fu T, Nagai Y, Lam L, Yee M, Zhu Z and Zhang H: scFv-based "grababody" as a general strategy to improve recruitment of immune effector cells to antibody-targeted tumors. Cancer Research 73(8): 2619-27, Apr 2013.

Runkle EA, Zhang H, Cai Z, Zhu Z, Karger BL, Wu SL, O'Rourke DM, Zhou Z, Wang Q, Greene MI: Reversion of the ErbB malignant phenotype and the DNA damage response. Experimental and molecular pathology 93(3): 324-33, Dec 2012.

Song X, Li B, Xiao Y, Chen C, Wang Q, Liu Y, Berezov A, Xu C, Gao Y, Li Z, Wu SL, Cai Z, Zhang H, Karger BL, Hancock WW, Wells AD, Zhou Z, Greene MI: Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function. Cell reports 1(6): 665-75, Jun 2012.

Berezov A, Cai Z, Freudenberg J A, Zhang H, Cheng X, Thompson T, Murali R, Greene M I, Wang Q: Disabling the mitotic spindle and tumor growth by targeting a cavity-induced allosteric site of survivin. Oncogene 31(15): 1938-48, Apr 2012.

Zhou Z*, Du X*, Cai Z*, Song X, Zhang H, Mizuno T, Suzuki E, Yee MR, Berezov A, Murali R, Wu SL, Karger BL, Greene MI, Wang Q. (* co-first author): Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope. The Journal of biological chemistry 287(8): 5317-26, Feb 2012 Notes: * Co-first author.

Cai Z, Zhang H, Liu J, Berezov A, Murali R, Wang Q, Greene MI.: Targeting erbB receptors. Seminars in cell & developmental biology 21(9): 961-6, Dec 2010.

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Last updated: 10/20/2017
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