Vijay Srinivasan, MBBS, MD

faculty photo
Associate Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania and the Children's Hospital of Philadelphia
Adjunct Faculty, University of Pennsylvania School of Nursing, Philadelphia, PA
Member, Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA, University of Pennsylvania
Advisory Dean, Nathan Mossell House, Perelman School of Medicine, University of Pennsylvania
Member, Penn Center for Nutritional Science and Medicine (PenNSAM), University of Pennsylvania, Philadelphia, PA
Education Advisor, Ex-officio Member, Committee on Appointments and Promotions, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
Department: Anesthesiology and Critical Care

Contact information
Department of Anesthesiology and Critical Care Medicine
6036, Wood Building 6th floor
The Children's Hospital of Philadelphia
3401 Civic Center Blvd
Philadelphia, PA 19104-4399
Office: 215-590-5505
Fax: 267-426-5574
Education:
MBBS
All-India Institute of Medical Sciences, New Delhi, India, 1995.
MD (Pediatrics)
All-India Institute of Medical Sciences, New Delhi, India, 1998.
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Description of Clinical Expertise

Dr. Srinivasan is a full-time attending physician at the Pediatric Intensive Care Unit (PICU) and Progressive Care Unit (PCU) at CHOP. The PICU at CHOP is a 68-bed tertiary care medical/surgical unit with approximately 4200 admissions every year and serves the Delaware Valley region of south-eastern Pennsylvania and adjoining southern New Jersey with national international referrals. The PICU offers advanced modes of ventilation, nitric oxide therapy, surfactant therapy, continuous and intermittent renal replacement therapies, extracorporeal life support therapy and advanced modes of blood exchanges. The PICU offers an accredited 3 year fellowship program supervised by board-certified PICU faculty members. The PICU manages all patients with close input from multiple consulting services and sub-specialties.

Description of Other Expertise

Dr. Srinivasan is an Advisory Dean at the Perelman School of Medicine at the University of Pennsylvania. He serves as an invited small group facilitator for the Doctoring program for medical students at the Perelman School of Medicine at the University of Pennsylvania and has been active in this role for over 10 years. He is also an invited course facilitator for FR601 – Frontiers in Bioethics and Professionalism, for 4th year medical students at the Perelman School of Medicine at the University of Pennsylvania. Dr. Srinivasan also champions wellness initiatives for students and colleagues using observation and reflection with art in medicine.

Description of Research Expertise

Dr. Srinivasan is engaged in research in endocrinopathies and nutrition in critically ill children. He was a Co-Investigator (10% effort) and local site PI on the NHLBI funded Heart and Lung Failure - Pediatric Insulin Titration (HALF-PINT) study (NHLBI/HL107681 PI: Agus/Nadkarni) involving multiple PALISI sites. He was also site PI for the ancillary study Coagulation and Fibrinolysis - Pediatric Insulin Titration (CAF-PINT) with HALF-PINT. Locally, he studies the association of stress hyperglycemia/ blood glucose variability with key outcomes in the PICU population. Dr. Srinivasan also seeks to improve anthropometry measurements and delivery of enteral nutrition in the PICU population. He is PI of a CHOP CTRC supported study on measurement and validation of resting energy expenditure in children chronically mechanically ventilated via tracheostomy. He is PI of an industry sponsored study with NIH SBIR/STTR support to evaluate the efficacy of using TubeClear to restore patency in occluded enteral access devices in children in the ICU. He is collaborating with Dr. Katri Typpo (University of Arizona) to study the role of biomarkers of effects of enteral/parenteral nutrition on intestinal epithelium in the SUPPER study. Dr. Srinivasan is a founding member of the PALISI Nutrinet group to define nutrition specific common data elements for clinical trials of nutrition in critically ill children.

Selected Publications

Mataya LA, Bittermann T, Quarshie WO, Griffis H, Srinivasan V, Rand EB, Alcamo AM.: Status 1B designation does not adequately prioritize children with acute on chronic liver failure (ACLF) for liver transplantation. Liver Transplantation February 1 2022 Notes: Epub ahead of print. DOI: 10.1002/lt.26436.

Hunter RB, Guzman H, Christiano J, Lord K, Kirschen M, Srinivasan V: Diagnosis and Management of Central Diabetes Insipidus in Critically Ill Children Varies Between Critical Care Medicine and Endocrinology Providers. Journal of Pediatric Intensive Care revisions 2022.

Kienzle MF, Morgan RW, Dewan M, Hebbar KH, Nadkarni VM, Srinivasan V, Tegtmeyer K, Sutton RM, Wolfe HA: Weight-Based Versus Flat Dosing of Epinephrine During Cardiac Arrest in the Pediatric Intensive Care Unit: A Multi-Center Survey. Pediatric Critical Care Medicine in press 2022.

Brown AM, Irving SY, Pringle C, Allen CH, Brown M, Nett S, Singleton MN, Mikhailov TA, Madsen E, Srinivasan V, Anthony H, Forbes M: Bolus gastric feeds improve nutritional delivery to mechanically ventilated pediatric medical patients: results of the COntinuous vs Bolus (COBO2) multi-center trial. JPEN J Parenteral Enteral Nutrition December 8 2021 Notes: doi: 10.1002/jpen.2305. Epub ahead of print.

LaMarra D, French J, Bailey C, Sisko MT, Coughlin-Wells K, Agus MSD, Srinivasan V, Nadkarni VM for the HALF-PINT Study Investigators: A novel framework using remote telesimulation with standardized parents to improve research staff preparedness for informed consent in pediatric critical care research. Pediatric Critical Care Medicine 21(12): e1042-e1051, December 2020.

Srinivasan V, Hasbani N, Mehta NM, Irving SY, Kandil S, Allen HC, Typpo KV, Cvijanovich N, Faustino EVS, Wypij D, Agus MSD, and Nadkarni VM for the HALF-PINT Study Investigators: Early enteral nutrition is associated with improved clinical outcomes in critically ill children: a secondary analysis of nutrition support in the HALF-PINT study. Pediatric Critical Care Medicine 21(3): 213-221, March 2020.

Kaushal T, Lord K, Olsen R, Mehta S, Clark S, Laskin B, Traynor D, Taylor A, Shaw K, Srinivasan V. : Improving disposition decision-making for pediatric DKA: A quality improvement study. Pediatric Quality and Safety 5(2): e260, March/April 2020 Notes: doi: 10.1097/pq9.0000000000000260.

Marsillio LE, Asaro LA, Srinivasan V, Wypij D. Sorce LR, Agus MSD, Nadkarni VM for the Heart And Lung Failure-Pediatric INsulin Titration (HALF-PINT) Study Investigators: Outcomes associated with multiple organ dysfunction syndrome in critically ill children with hyperglycemia. Pediatric Critical Care Medicine 20(12): 1147-1156, December 2019.

Faustino EVS, Hirshberg EL, Asaro LA, Biaga KV, Pinto N, Srinivasan V, Bagdure DN, Steil GM, Coughlin-Wells K, Wypij D, Nadkarni VM, Agus MSD for the HALF-PINT Study Investigators. : Short-term adverse outcomes associated with hypoglycemia in critically ill children. Critical Care Medicine 47(5): 706-714, May 2019.

Irving SY, Daly B, Verger J, Typpo KV, Brown AM, Hanlon A, Weiss SL, Fitzgerald JC, Nadkarni VM, Thomas NJ, Srinivasan V: The association of nutrition status expressed as body mass index z-score with outcomes in children with severe sepsis: a secondary analysis from the Sepsis Prevalence, Outcomes and Therapies (SPROUT) study. Critical Care Medicine 46(11): e1029-e1039, November 2018 Notes: Senior author.

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Last updated: 06/28/2022
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