Vijay Srinivasan, MD
Department of Anesthesiology and Critical Care Medicine
3401 Civic Center Boulevard
Philadelphia, PA 19104-4399
All-India Institute of Medical Sciences, New Delhi, India, 1995.
All-India Institute of Medical Sciences, New Delhi, India, 1998.
Description of Clinical ExpertiseDr. Srinivasan is a full-time attending physician at the Pediatric Intensive Care Unit (PICU) and Progressive Care Unit (PCU) at CHOP. The PICU at CHOP is a 55-bed tertiary care medical/surgical unit with approximately 3700 admissions every year and serves the Delaware Valley region of south-eastern Pennsylvania and adjoining southern New Jersey with national international referrals. The PICU offers advanced modes of ventilation, nitric oxide therapy, surfactant therapy, continuous and intermittent renal replacement therapies, extracorporeal life support therapy and advanced modes of blood exchanges. The PICU offers an accredited 3 year fellowship program supervised by board-certified PICU faculty members. The PICU manages all patients with close input from multiple consulting services and sub-specialties.
Description of Other ExpertiseDr. Srinivasan is an invited small group facilitator for the Doctoring program for medical students at the Perelman School of Medicine at the University of Pennsylvania and has been active in this role for over 10 years. He is also an invited course facilitator for FR601 – Frontiers in Bioethics and Professionalism, for 4th year medical students at the Perelman School of Medicine at the University of Pennsylvania.
Description of Research ExpertiseDr. Srinivasan is engaged in research in endocrinopathies and nutrition in critically ill children. He is a Co-Investigator (10% effort) and local site PI on the NHLBI funded Heart and Lung Failure - Pediatric Insulin Titration (HALF-PINT) study (NHLBI/HL107681 PI: Agus/Nadkarni) involving multiple PALISI sites. He is also site PI for the ancillary study Coagulation and Fibrinolysis - Pediatric Insulin Titration (CAF-PINT) with HALF-PINT. Locally, he studies the association of stress hyperglycemia/ blood glucose variability with key outcomes in the PICU population. Dr. Srinivasan also seeks to improve anthropometry measurements and delivery of enteral nutrition in the PICU population. He is PI of a CHOP CTRC supported study on measurement and validation of resting energy expenditure in children chronically mechanically ventilated via tracheostomy. He is PI of an industry sponsored study with NIH SBIR/STTR support to evaluate the efficacy of using TubeClear to restore patency in occluded enteral access devices in children in the ICU. He is collaborating with Dr. Katri Typpo (University of Arizona) to study the role of biomarkers of effects of enteral/parenteral nutrition on intestinal epithelium in the SUPPER study.
Selected PublicationsMarsillio LE, Asaro LA, Srinivasan V, Wypij D. Sorce LR, Agus MSD, Nadkarni VM for the Heart And Lung Failure-Pediatric INsulin Titration (HALF-PINT) Study Investigators: Outcomes associated with multiple organ dysfunction syndrome in critically ill children with hyperglycemia. Pediatric Critical Care Medicine 20(12): 1147-1156, December 2019.
Srinivasan V, Hasbani N, Mehta NM, Irving SY, Kandil S, Allen HC, Typpo KV, Cvijanovich N, Faustino EVS, Wypij D, Agus MSD, and Nadkarni VM for the HALF-PINT Study Investigators: Early enteral nutrition is associated with improved clinical outcomes in critically ill children: a secondary analysis of nutrition support in the HALF-PINT study. Pediatric Critical Care Medicine October 2. Epub ahead of print 2019.
Faustino EVS, Hirshberg EL, Asaro LA, Biaga KV, Pinto N, Srinivasan V, Bagdure DN, Steil GM, Coughlin-Wells K, Wypij D, Nadkarni VM, Agus MSD for the HALF-PINT Study Investigators. : Short-term adverse outcomes associated with hypoglycemia in critically ill children. Critical Care Medicine 47(5): 706-714, May 2019.
Irving SY, Daly B, Verger J, Typpo KV, Brown AM, Hanlon A, Weiss SL, Fitzgerald JC, Nadkarni VM, Thomas NJ, Srinivasan V: The association of nutrition status expressed as body mass index z-score with outcomes in children with severe sepsis: a secondary analysis from the Sepsis Prevalence, Outcomes and Therapies (SPROUT) study. Critical Care Medicine 46(11): e1029-e1039, November 2018 Notes: Senior author.
Stinson HR, Srinivasan V, Topjian AA, Sutton RM, Nadkarni VM, Berg RA, Raymond TT, for the American Heart Association Get with the Guidelines-Resuscitation Investigators: Failure of invasive airway placement on the first attempt is associated with progression to cardiac arrest in pediatric acute respiratory compromise. Pediatric Critical Care Medicine 19(1): 9-16, January 2018.
Nichols B, Kubis SE, Hewlett JL, Yehya N, Srinivasan V: Hydrocortisone therapy in catecholamine resistant pediatric septic shock: a pragmatic analysis of clinician practice and association with outcomes. Pediatric Critical Care Medicine 18(9): e406-e414, September 2017.
Srinivasan V, Pung D, O'Neil SP: Conversion from Prolonged Intravenous Fentanyl Infusion to Enteral Methadone in Critically Ill Children World Journal of Clinical Pediatrics 6(2): 110-117, May 2017.
Srinivasan V, Seiple S, Nagle M, Falk S, Kubis S, Lee HM, Sisko M, Mascarenhas M, Irving S: Improving the Performance of Anthropometry Measurements in the Pediatric Intensive Care Unit Pediatric Quality and Safety 2(e22), May 2017 Notes: doi: 10.1097/pq9.0000000000000022.
Agus MS, Hirshberg E, Srinivasan V, Faustino EV, Luckett PM, Curley MAQ, Alexander J, Asaro LA, Coughlin-Wells K, Duva D, French J, Hasbani N, Sisko MT, Soto-Rivera CL, Steil G, Wypij D, Nadkarni VM, and HALF-PINT Study Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators Network.: Design and rationale of Heart and Lung Failure – Pediatric INsulin Titration Trial (HALF-PINT): A randomized clinical trial of tight glycemic control in hyperglycemic critically ill children. Contemporary Clinical Trials 53: 178-187, February 2017 Notes: doi: 10.1016/j.cct.2016.12.023 [Epub ahead of print, December 2016]
Agus MSD, Wypij D, Hirshberg EL, Srinivasan V, Faustino EV, Luckett PM, Alexander JL, Asaro, LA, Curley MAQ, Steil GM, Nadkarni VM, for the HALF-PINT Study Investigators and PALISI Network. : Tight glycemic control in critically ill children. New England Journal of Medicine 376: 729-741, February 2017 Notes: PI at CHOP and Co-I on national trial - enrolled 85 subjects (maximum enrollment of all 33 centers) at CHOP; also enrolled 44 subjects for ancillary study (CAF-PINT) at CHOP (maximum enrollment of all 33 centers).