Kirk J Wangensteen, MD, PhD

faculty photo
Assistant Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Division of Gastroenterology
421 Curie Boulevard, BRB 910
Philadelphia, PA 19104
Office: 2155737314
Fax: 2158980573
BA (Biological Sciences)
Northwestern University, 2000.
PhD (Biochemistry, Molecular Biology, and Biophysics)
University of Minnesota, 2007.
MD (Medicine)
University of Minnesota, 2009.
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Description of Clinical Expertise

Kirk Wangensteen, MD/PhD specializes in Gastroenterology and Hepatology and his clinical expertise includes genetic diseases of the gastrointestinal tract, pancreas, and liver.

Description of Research Expertise

Kirk Wangensteen, MD/PhD's research expertise includes liver biology and genetics. In particular, he is mapping the genetic pathways that enable liver regeneration and cause liver cancer. He has set up innovative in vivo screening systems to elucidate these pathways in a mouse model of liver injury and repopulation.

Selected Publications

Wangensteen KJ, Chang KM.: Multiple Roles for Hepatitis B and C Viruses and the Host in the Development of Hepatocellular Carcinoma. Hepatology 73: 27-37, Jan 2021.

Huasheng Yu, Kirk Wangensteen, Tong Deng, Yulong Li, Wenqin Luo: MRGPRX4 in Cholestatic Pruritus. Seminars in Liver Disease 2021 Notes: In Press.

Kumar S, Dudzik CM, Reed M, Long JM, Wangensteen KJ, Katona BW.: Upper Endoscopic Surveillance in Lynch Syndrome Detects Gastric and Duodenal Adenocarcinomas. Cancer Prev Res (Phila) 13: 1047-1054, Dec 2020.

Yin Dingzi, Wang Amber W, Erez Noam, Wangensteen Kirk J: An in vivo dropout CRISPRi screen for regulators of liver regeneration. Hepatology November 2020 Notes: Poster at the AASLD Liver Meeting Digital Experience.

Yin Dingzi, Erez Noam, Wangensteen Kirk J: A pooled in vivo CRISPRi screen identifies synthetic lethal partners of MYC in hepatocellular carcinoma development. Hepatology November 2020 Notes: Oral presentation at the AASLD Liver Meeting Digital Experience.

Yin Dingzi and Wangensteen Kirk J: Incapacitated Capicua in Sorafenib-Resistant HCC. Cell Mol Gastroenterol Hepatol 10(2): 428-429, Apr 2020.

Zahm Adam M, Wang Amber W, Wang Yue J, Schug Jonathan, Wangensteen Kirk J*, Kaestner Klaus H*: A High-Content Screen Identifies MicroRNAs That Regulate Liver Repopulation After Injury in Mice. Gastroenterology 158(4): 1044-1057 e17, Mar 2020 Notes: *co-corresponding.

Zhao Xiao*, Wangensteen Kirk J*: Inflammasome-more Injury in Cholestasis. Cell Mol Gastroenterol Hepatol 9(4): 711-712, 2020 Notes: *co-corresponding.

Mezina Anya, Philips Neil, Bogus Zoe, Erez Noam, Nathanson Katherine, Hoteit Maarouf, Wangensteen Kirk J: Prevalence of pathogenic germline variants in cancer-risk genes in hepatocellular carcinoma. Gastroenterology 2020 Notes: Poster. (Conference canceled due to COVID-19.).

Wang Amber W, Wang Yue J, Zahm Adam M, Morgan Ashley R, Wangensteen Kirk J, Kaestner Klaus H.: The Dynamic Chromatin Architecture of the Regenerating Liver. Cell Mol Gastroenterol Hepatol 9(1): 121-143, 2020.

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Last updated: 04/05/2021
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