Kirk J Wangensteen, MD, PhD

faculty photo
Assistant Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Division of Gastroenterology
421 Curie Boulevard, BRB 910
Philadelphia, PA 19104
Office: 2155737314
Fax: 2158980573
BA (Biological Sciences)
Northwestern University, 2000.
PhD (Biochemistry, Molecular Biology, and Biophysics)
University of Minnesota, 2007.
MD (Medicine)
University of Minnesota, 2009.
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Description of Clinical Expertise

Kirk Wangensteen, MD/PhD specializes in Gastroenterology and Hepatology and his clinical expertise includes genetic diseases of the gastrointestinal tract, pancreas, and liver.

Description of Research Expertise

Kirk Wangensteen, MD/PhD's research expertise includes liver biology and genetics. In particular, he is mapping the genetic pathways that enable liver regeneration and cause liver cancer. He has set up innovative in vivo screening systems to elucidate these pathways in a mouse model of liver injury and repopulation.

Selected Publications

Mahmud Nadim, Wangensteen Kirk J: Colocolic intussusception. Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology Feb 2019.

Kieckhaefer Julia E, Maina Flavio, Wells Rebecca G, Wangensteen Kirk J: Liver Cancer Gene Discovery Using Gene Targeting, Sleeping Beauty, and CRISPR/Cas9. Seminars in liver disease 39(2): 261-274, 05 2019.

Wang Amber W, Zahm Adam M, Wangensteen Kirk J: Cell Type-Specific Gene Expression Profiling in the Mouse Liver. JOVE 2019 Notes: In press.

Preziosi Morgan E, Zahm Adam M, Vázquez-Salgado Alexandra M, Ackerman Daniel, Gade Terence P, Kaestner Klaus H, Wangensteen Kirk J: LXR agonism potentiates Sorafenib activity in HCC by inducing metabolic stress. Hepatology 2019 Notes: Selected for the Professor Margit Hamosh Memorial Travel Award, presented to a fellow or junior investigator within three years of their appointment who submits the most outstanding abstract on hepatocellular carcinoma research for The Liver Meeting.

Preziosi, Morgan E., Zahm, Adam M., Kaestner, Klaus H., Wangensteen, Kirk J.: LXR agonism and Sorafenib treatment as novel combination therapy for hepatocellular carcinoma. The FASEB Journal. Federation of American Societies for Experimental Biology, 33(1_supplement): 126.9-126.9, 2019 Notes: Oral presentation.

Wangensteen Kirk J, Wang Yue J, Dou Zhixun, Wang Amber W, Mosleh-Shirazi Elham, Horlbeck Max A, Gilbert Luke A, Weissman Jonathan S, Berger Shelley L, Kaestner Klaus H: Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform. Hepatology (Baltimore, Md.) 68(2): 663-676, Aug 2018.

Wang Amber W*, Wangensteen Kirk J*, Wang Yue J, Zahm Adam M, Moss Nicholas G, Erez Noam, Kaestner Klaus H: TRAP-seq identifies cystine/glutamate antiporter as a driver of recovery from liver injury. The Journal of clinical investigation 128(6): 2297-2309, Jun 2018 Notes: * co-first authors.

Wang Chao, Chen Wen-Jian, Wu Ying-Fu, You Pu, Zheng Shang-Yong, Liu Chang-Cheng, Xiang Dao, Wang Min-Jun, Cai Yong-Chao, Zhao Qing-Hui, Borjigin Uyunbilig, Liu Wei, Xiong Wu-Jun, Wangensteen Kirk J, Wang Xin, Liu Zhong-Min, He Zhi-Ying: The extent of liver injury determines hepatocyte fate toward senescence or cancer. Cell death & disease 9(5): 575, May 2018.

Shoshkes-Carmel Michal, Wang Yue J, Wangensteen Kirk J, Tóth Beáta, Kondo Ayano, Massassa Efi E, Itzkovitz Shalev, Kaestner Klaus H: Subepithelial telocytes are an important source of Wnts that supports intestinal crypts. Nature 557(7704): 242-246, May 2018.

Mahmud Nadim, Wangensteen Kirk J: Endoscopic Band Ligation to Treat a Massive Hemorrhoidal Hemorrhage Following a Transrectal Ultrasound-Guided Prostate Biopsy. Annals of coloproctology 34(1): 47-51, Feb 2018.

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Last updated: 09/11/2019
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