Mark E. Mikkelsen, MD, MSCE, FCCM

faculty photo
Associate Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Gates 05037
3400 Spruce Street
Hospital of the University of Pennsylvania
Philadelphia, PA 19104
Office: (215) 615-5416
Fax: (215) 614-0869
Lab: (267) 285-6602
BA (Political Science)
Colgate University, Hamilton, NY, 1996.
(Post-Baccalaureate Pre-Medical Degree Program)
Bryn Mawr College, Bryn Mawr, PA, 1997.
MD (Medical Degree)
University of Virginia School of Medicine, Charlottesville, VA, 2002.
MSCE (Clinical Epidemiology and Biostatistics)
University of Pennsylvania, Philadelphia, PA, 2008.
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Description of Research Expertise

Dr. Mikkelsen is the Chief of the Section of Medical Critical Care at Penn. He serves as Co-Chair of the UPHS Critical Care Alliance, PENN Medicine Sepsis Alliance and Medical Director of the Penn Presbyterian Medical Intensive Care Unit. Through these efforts, he supports the growth and development of a phenomenal group of multidisciplinary Penn providers who are collectively driven to educate the next generation of critical care clinicians, to deliver care of the highest quality to the critically ill, and to create and implement innovative science that advances the field of critical care medicine.

Research Program:
Through the lens of the patient and their family, Dr. Mikkelsen conducts patient-oriented research focused on sepsis, acute respiratory distress syndrome, and long-term outcomes in survivors of critical illness. He is passionate in his goal to improve the delivery of care to pulmonary and critical care patients and to improve the lives of survivors of critical illness by understanding how critical illness impacts one's life and one's health trajectory.

Dr. Mikkelsen encourages colleagues, as well as survivors of critical illness and their loved ones, who are committed to improving the quality of care delivered to critically ill patients to contact him at Together, we can "be the difference."

Description of Clinical Expertise

Dr. Mikkelsen's philosophy for patient care is to ensure that exceptional, compassionate care is delivered to patients with pulmonary disease and those who experience critical illness through outstanding, multi-disciplinary teamwork across the continuum of care, through the application of evidence-based care, and through systematic study to optimize our performance. Dr. Mikkelsen is an expert in pulmonary diseases and critical care medicine, and the devastating syndromes of sepsis, acute respiratory distress syndrome, and post-intensive care syndrome specifically.

Dr. Mikkelsen partners with state and national government agencies to improve care delivery for the critically ill. He served as Co-Chair of the Society of Critical Care Medicine's Thrive: Supporting Survivors of Critical Illness Initiative, Chair of the SCCM Internal Medicine Section, and was Co-Chair of the 2018 SCCM Congress in San Antonio, Texas. He served on the American Thoracic Society's Quality Improvement and Implementation Committee and Chairs the ATS Critical Care Assembly Planning Committee.

Description of Other Expertise

Dr. Mikkelse completed the LeadingSuccess Program through the Office of Organization Effectiveness, Raymond and Ruth Perelman School of Medicine, University of Pennsylvania, 2015-2016

Selected Publications

Ginestra JC, Atkins J, Mikkelsen ME, Mitchell OJL, Gutsche J, Jablonski J, Panchanadam V, Junker P, Schweickert W, Fuchs BD, Wani A: The I-READI quality and safety framework: a health system's response to airway complications in mechanically ventilated COVID-19 patients. NEJM Cat 2(1), Jan 2021 Notes: DOI:

McPeake J, Iwashyna TJ, Boehm LM, Hibbert E, Bakhru RN, Bastin AJ, Butcher BW, Eaton TL, Harris W, Hope AA, Jackson J, Meyer J, Montgomery-Yates A, Mikkelsen ME, Slack A, Wade D, Still M, Netzer G, Hopkins RO, Quasim T, Sevin CM, Haines KJ: Benefits of peer support for intensive care unit survivors: sharing experiences, care debriefing, and altruism. Am J Crit Care 30(2): 145-149, 2021.

Dubin R, Veith JM, Grippi MA, McPeake J, Harhay MO, Mikkelsen ME : Functional outcomes, goals, and goal attainment amongst chronically critically ill long-term acute care hospital patients Ann Amer Thorac Soc 2021.

Kerlin MP, Klaiman T, Gutsche JT, Jablonski J, Mikkelsen ME: Critical care clinician well-being during the COVID-19 pandemic: a longitudinal analysis. TBD 2021.

Haines KJ, Hibbert E, Leggett N, Boehm LM, Hall T, Bakhru RN, Bastin AJ, Butcher BW, Eaton TL, Harris W, Hope AA, Jackson J, Johnson A, Kloos JA, Korzick KA, Mactavish P, Meyer J, Montgomery-Yates A, Qasim T, Slack A, Wade D, Still M, Netzer G, Hopkins RO, Iwashyna TJ, Mikkelsen ME, McPeake J, Sevin CM: Transitions of care after critical illness: challenges to recovery and adaptive problem solving. Crit Care Med 2021.

Hope AA, Johnson A, McPeake J, Felt H, Sevin CM, Mikkelsen ME, Iwashyna TJ, Lassen-Greene CL, Haines KJ, Agarwal S, Bakhru R, Bastin A, Beesley S, Boehm LM, Butcher B, Drumright K, Eaton T, Hibbert E, Hirshberg E, Hoehn S, Hornstein D, Imperato-Shedden H, Jackson JC, Kloos J, Lewis A, Puri N, Rojas V, Schorr C, Wade D, Williams C: Establishing a peer support program for survivors of COVID-19: a report from the Critical and Acute Illness Recovery Organization. Am J Crit Care 2021 Notes: doi:

Maley JH, Mikkelsen ME: The intersection of health and critical illness: preservation and restoration. Am J Respir Crit Care Med 2021 Notes: Editorial

Anesi GL, Jablonski J, Harhay MO, Atkins JH, Bajaj J, Baston C, Brennan PJ, Candeloro CL, Catalano LM, Cereda MF, Chandler JM, Christie JD, Collins T, Courtright KR, Fuchs BD, Gordon E, Greenwood JC, Gudowski S, Hanish A, Hanson CW, Heuer M, Kinniry P, Kornfield ZN, Kruse GB, Lane-Fall, Martin ND, Mikkelsen ME, Negoianu D, Pascual JL, Patel MB, Pugliese SC, Qasim ZA, Reilly, Salmon J, Schweickert WD, Scott MJ, Shashaty MGS, Sicoutris CP, Wang JK, Wang W, Wani AA, Anderson BJ, Gutsche JT: Characteristics, outcomes, and trends of patients with COVID-19–related critical illness at a learning health system in the U.S. Annals Intern Med 2021 Notes: 2021 Jan 19;M20-5327. doi: 10.7326/M20-5327. Online ahead of print.

Derry HM, Mikkelsen ME: Early forecasting of later PTSD symptoms after critical illness: partly cloudy but clearing Crit Care Med 48(11): 1694-1696, Nov 2020.

Usman AA, Han J, Acker A, Olia SE, Bermudez C, Cucchiara B, Mikkelsen ME, Wald J, Mackay E, Szeto W, Vernick WJ, Gutsche JT: A case series of devastating intracranial hemorrhage during venovenous extracorporeal membrane oxygenation for COVID-19. J Cardio Vasc Anes 34(11): 3006-3012, Nov 2020.

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Last updated: 04/29/2021
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