Mark E. Mikkelsen, MD, MSCE, FCCM

faculty photo
Associate Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Gates 05042
3400 Spruce Street
Hospital of the University of Pennsylvania
Philadelphia, PA 19104
Office: (215) 615-5416
Fax: (215) 614-0869
Lab: (267) 285-6602
BA (Political Science)
Colgate University, Hamilton, NY, 1996.
(Post-Baccalaureate Pre-Medical Degree Program)
Bryn Mawr College, Bryn Mawr, PA, 1997.
MD (Medical Degree)
University of Virginia School of Medicine, Charlottesville, VA, 2002.
MSCE (Clinical Epidemiology and Biostatistics)
University of Pennsylvania, Philadelphia, PA, 2008.
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Description of Research Expertise

Dr. Mikkelsen is the Chief of the Section of Medical Critical Care at Penn. He serves as Co-Chair of the UPHS Critical Care Committee and Medical Director of the Penn Presbyterian Medical Intensive Care Unit. Through these efforts, he supports the growth and development of a phenomenal group of multidisciplinary Penn providers who are collectively driven to educate the next generation of critical care clinicians, to deliver care of the highest quality to the critically ill, and to create and implement innovative science that advances the field of critical care medicine.

Research Program:
Through the lens of the patient and their family, Dr. Mikkelsen conducts patient-oriented research focused on sepsis, acute respiratory distress syndrome, and long-term outcomes in survivors of critical illness. He is passionate in his goal to improve the delivery of care to critically ill patients and to improve the lives of survivors of critical illness by understanding how critical illness impacts one's life and one's health trajectory.

Dr. Mikkelsen encourages colleagues, as well as survivors of critical illness and their loved ones, who are committed to improving the quality of care delivered to critically ill patients to contact him at Together, we can "be the difference."

Description of Clinical Expertise

Dr. Mikkelsen's philosophy for patient care is to ensure that exceptional, compassionate care is delivered to critically ill patients and their family members through outstanding, multi-disciplinary teamwork across the continuum of care, through the application of evidence-based care, and through systematic study to optimize our performance. Dr. Mikkelsen is an expert in critical care medicine, and the devastating syndromes of sepsis, acute respiratory distress syndrome, and post-intensive care syndrome specifically.

Dr. Mikkelsen partners with state and national government agencies to improve care delivery for the critically ill. He serves as Co-Chair of the Society of Critical Care Medicine's Thrive: Supporting Survivors of Critical Illness Initiative, Chair of the SCCM Internal Medicine Section, and was Co-Chair of the 2018 SCCM Congress in San Antonio, Texas. He also serves on the American Thoracic Society's Quality Improvement and Implementation Committee.

Selected Publications

Kerlin MP, McPeake J, Mikkelsen ME: Burnout, and joy, in the profession of critical care medicine. Crit Care 2020 Notes: In press.

Maley JH, Mikkelsen ME: A Post-intensive care syndrome (PICS) free future -- what we need to address now. Improving critical care survivorship. Haines K, Sevin C, McPeake J (eds.). Springer, 2020 Notes: Chapter.

McPeake J, Mikkelsen ME, Quasim T, Hibbert E, Cannon P, Shaw M, Ankori J, Iwashyna TJ, Haines KJ: Return to employment following critical illness and its association with psychosocial outcomes: a systematic review and meta-analysis. Ann Am Thor Soc 2019 Notes: In press.

Bowles KH, Murtaugh CM, Jordan L, Barron Y, Mikkelsen ME, Whitehouse CR, Chase JD, Ryvicker M, Feldman PH: A profile of sepsis survivors transitioned to home health care and early readmission risk factors JAMDA 2019.

Mikkelsen ME, Hopkins RO, Sevin CM: Post-Intensive Care Syndrome (PICS) and Strategies to Mitigate PICS Development Society of Critical Care Medicine ICU Liberation. Ward K (eds.). 2019.

McPeake JM, Harhay MO, Devine H, Iwashyna TJ, MacTavish, Mikkelsen ME. Shaw M, Qasim T : Exploring patients’ goals within the intensive care unit rehabilitation setting. Am J Crit Care 28(5), 393-400 2019.

Amaral ACKB, Vincent JL, Rose L, Mikkelsen ME, Webb S, Ramos GV, Pinto R, Salluh J.: An international perspective on the frequency, perception of utility, and quality of interprofessional rounds practices in intensive care units. J Crit Care 2019 Notes: In press.

Lee JT, Mikkelsen ME, Qi M, Werner RM: Health care utilization after admissions for sepsis. Ann Am Thorac Soc 2019 Notes: In press.

Deb P, Murtaugh CM, Bowles KH, Mikkelsen ME, Khajavi HN, Moore S, Barrón Y, Hollander Feldman P: Does Early Follow-up Improve the Outcomes of Sepsis Survivors Discharged to Home Health Care? Med Care 2019 Notes: In press.

Mikkelsen ME, Anderson BJ, Bellini L, Schweickert WD, Fuchs BD, Prasad Kerlin M: Burnout, and fulfillment, in the profession of critical care medicine. Am J Respir Crit Care Med 2019 Notes: In press.

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Last updated: 12/20/2019
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