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Ran Reshef, MD, MSc

Ran Reshef, MD, MSc

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Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Hospital of the University of Pennsylvania
Division of Hematology & Oncology
Perelman Center for Advanced Medicine, 2nd floor West
3400 Civic Center Blvd.
Philadelphia, PA 19104
Office: 2153498940
Fax: 2156155887
Lab: 2155730642
B.Med.Sci. (Medical Science)
Tel-Aviv University, Israel, 1996.
M.D. (Medicine)
Sackler School of Medicine at Tel-Aviv University, Israel, 2003.
M.Sc. (Translational Research)
University of Pennsylvania, 2011.
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Description of Clinical Expertise

I conduct translational research in cellular therapy. My research focuses on finding new ways to modulate the graft-versus-host and graft-versus-tumor effects and improve the outcomes of stem-cell transplants in patients with blood cancers. Ongoing projects include determining the role of chemokine receptors in transplantation, and incorporating genomic methods to characterize the risk for graft-versus-host disease in order to develop targeted and personalized strategies to prevent it.

Description of Research Expertise

I am a physician scientist with a translational research focus in immunotherapy and cellular therapy. My research goals are to advance the understanding of immune responses mediated by cellular therapies, and to develop approaches that improve their efficacy and/or mitigate their toxicity. In particular, I am interested in how genetic variability affects immune responses and explains the heterogeneity in outcomes of cellular therapies and other immunotherapies. My chief hypothesis is that cellular therapies can be optimized by using personalized approaches that are based on understanding of the genetic heterogeneity of tumors, hosts and donors. In this context, my lab studies the role of lymphocyte trafficking receptors in anti-host and anti-tumor responses, which we have translated into a therapeutic intervention in humans using the CCR5 antagonist maraviroc.

Selected Publications

Reshef R, Huffman AP, Gao A, Luskin MR, Hexner EO, Loren AW, Frey NV, Stadtmauer EA, Luger SM, Mangan JK, Nasta SD, Gill SI, Sell M, Kambayashi T, Richman LP, Vonderheide RH, Mick R, Porter DL : High Graft CD8 Cell Dose Predicts Improved Survival and Enables Better Donor Selection In Allogeneic Stem-Cell Transplantation With Reduced-Intensity Conditioning. J Clin Oncol In Press, 2015.

Karimi M, Richman LP, Bryson JL, Fesnak AD, Leichner TM, Satake A, Vonderheide RH, Raulet DH, Reshef R, Kambayashi T : Transient NKG2D Blockade Attenuates Graft-versus-Host Disease While Preserving Graft-versus-Tumor Effects. Blood In Press, 2015.

Reshef R, Porter DL: Reduced-intensity conditioning for allogeneic stem-cell transplantation in adults with acute myeloid leukemia. Bone Marrow Transplant In Press, 2015.

Reshef R, Hexner EO, Loren AW, Frey NV, Stadtmauer EA, Luger SM, Gill SI, Vassilev P, Lafferty KA, Smith J, Van Deerlin VM, Mick R, Porter DL : Early donor chimerism levels predict relapse and survival after allogeneic stem-cell transplantation with reduced intensity conditioning. Biol Blood Marrow Transplant 20(11): 1758-66, November 2014.

Levine JE, Hogan WJ, Harris AC, Litzow MR, Efebra YA, Devine SM, Reshef R, Ferrara JLM : Improved accuracy of acute graft-versus-host disease staging among multiple centers. Best Prac Res Clin Haematol 27(3-4): 283-287, Sept.-Dec. 2014.

Reshef R, Luger SM, Hexner EO, Loren AW, Frey NV, Nasta SD, Goldstein SC, Stadtmauer EA, Smith J, Bailey S, Mick R, Heitjan DF, Emerson SG, Hoxie JA, Vonderheide RH, Porter DL: Blockade of lymphocyte chemotaxis in visceral graft-versus-host disease. N Engl J Med 367(2): 135-45, July 2012.

Hardy NM, Fellowes V, Rose JJ, Hakim FT, Odom J, Pittaluga S, Steinberg SM, Blacklock-Schuver B, Avila DN, Memon S, Kurlander RJ, Khuu HM, Stetler-Stevenson M, Mena Gonzalez E, Dwyer AJ, Levine BL, June CH, Reshef R, Vonderheide RH, Gress RE, Fowler DH, Hakim FT, Bishop MR: Costimulated tumor-infiltrating lymphocytes are a feasible and safe alternative donor cell therapy for relapse after allogeneic stem cell transplantation. Blood 119(12): 2956-9, March 2012

Reshef R, Vardhanabhuti S, Luskin MR, Heitjan DF, Hadjiliadis D, Goral S, Krok KL, Goldberg LR, Porter DL, Stadtmauer EA, Tsai DE: Reduction of Immunosuppression as Initial Therapy for Post-Transplantation Lymphoproliferative Disorder. Am J Transplant 11(2): 336-347, 2011.

Reshef R, Luskin MR, Kamoun M, Vardhanabhuti S, Tomaszewski JE, Stadtmauer EA, Porter DL, Heitjan DF, Tsai DE: Association of HLA Polymorphisms with Post-Transplant Lymphoproliferative Disorder in Solid-Organ Transplant Recipients. Am J Transplant 11(4): 817-825, 2011.

Beatty GL, Smith JS, Reshef R, Patel KP, Colligon TA, Vance BA, Frey NV, Johnson FB, Porter DL, Vonderheide RH: Functional unresponsiveness and replicative senescence of myeloid leukemia antigen- specific CD8+ T cells after allogeneic stem cell transplantation. Clin Cancer Res 15: 4944-53, 2009.

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Last updated: 03/05/2015
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