Paschalis-Thomas Doulias, PhD

faculty photo
Research Assistant Professor of Pediatrics
Department: Pediatrics

Contact information
Children’s Hospital of Philadelphia Research Institute
416D Abramson Center
34th Street and Civic Center Boulevard
Philadelphia, PA 19104
Fax: (215) 590-4267
Lab: (215) 590-5319
Education:
BS (Chemistry)
University of Ioannina, Greece, 1998.
PhD (Biological Chemistry)
Medical School, University of Ioannina, Greece, 2005.
Permanent link
 
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Selected Publications

Zamani P, Tan VX, Soto-Calderon H, Beraun M, Brandimarto J, Trieu L, Varakantam S, Doulias PT, Townsend RR, Chittams J, Margulies KB, Cappola TP, Poole DC, Ischiropoulos H, Chirinos JA: Pharmacokinetics and Pharmacodynamics of Inorganic Nitrate in Heart Failure With Preserved Ejection Fraction. Circ Res 120(7): 1151-1161, Mar 2017.

Lin W, Vann DR, Doulias PT, Wang T, Landesberg G, Li X, Ricciotti E, Scalia R, He M, Hand NJ,Daniel J, Rader DJ: Hepatic SLC39A8/ZIP8 regulates whole-body manganese homeostasis and the activity of Mn-dependent enzymes. J Clin Invest 2017 Notes: In press.

Zamani P, French B, Brandimarto JA, Doulias PT, Javaheri A, Chirinos JA, Margulies KB, Townsend RR, Sweitzer NK, Fang JC, Ischiropoulos H, Cappola TP: Effect of Heart Failure With Preserved Ejection Fraction on Nitric Oxide Metabolites. Am J Cardiol 118(15): 1855-1860, Dec 2016.

Chirinos JA, Akers SR, Trieu L, Ischiropoulos H, Doulias PT, Tariq A, Vassim I, Koppula MR, Syed AA, Soto-Calderon H, Townsend RR, Cappola TP, Margulies KB, Zamani P: Heart Failure, Left Ventricular Remodeling, and Circulating Nitric Oxide Metabolites. J Am Heart Assoc 5(10): e004133, Oct 2016.

Trieu L, Zamani P, Tran V, Soto-Calderon H, Beraun M, Brandimarto JA, Varakantam S, Paschalis-Thomas Doulias P-T, Townsend RR, Chittams J, Margulies KB, Cappola TP, Poole DC, Ischiropoulos H, Chirinos JA. : Inorganic Nitrate Does Not Worsen Physical Activity. Journal of Cardiac Failure. Poster presentation, Proceedings of the 20th Annual Scientific Meeting of The Heart Failure Society of America (HSFA), Gaylord Palms, FL Sep-Oct 2016.

Chen F, Wang Y, Rafikov R, Haigh S, Zhi WB, Kumar S, Doulias PT, Rafikova O, Pillich H, Chakraborty T, Lucas R, Verin AV, Catravas JD, She JX, Black SM, Fulton D Jr: RhoA S-nitrosylation as a regulatory mechanism influencing endothelial barrier function in response to G+-bacterial toxins. Biochem Pharmacol 127: 34-45, 2016.

Irie T, Sips PY, Kai S, Kida K, Ikeda K, Hirai S, Moazzami K, Jiramongkolchai P, Bloch DB, Doulias PT, Armoundas AA, Kaneki M, Ischiropoulos H, Kranias E, Bloch KD, Stamler J, Ichinose F: S-Nitrosylation of Calcium-Handling Proteins in Cardiac Adrenergic Signaling and Hypertrophy. Circ Res 117(9): 793-803, Oct 2015.

Raju K, Doulias PT, Evans P, Krizman EN, Jackson JG, Horyn O, Daikhin Y, Nissim I, Yudkoff M, Nissim I, Sharp KA, Robinson MB, Ischiropoulos H : Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation. Science Sig 8(384): ra68, Jul 2015.

Tenopoulou M, Chen J, Bastin J, Bennett MJ, Ischiropoulos H, Doulias PT: Strategies for correcting very long chain acyl-CoA dehydrogenase deficiency. J Biol Chem 290(16): 10486-10494, Apr 2015.

Trieu L, Zamani P, Doulias P-T, Rawat D, Shiva Kumar P, Bhuva R, Vadde N, Dunde A, Soto-Calderon H, Tariq A, Javaheri A, Haines P, Ischiropoulos H, Akers S, Chirinos Medina J: Plasma Levels of Nitric Oxide Metabolites are lower in HFpEF subjects compared to HFrEF and hypertensives. Poster presentation, American College of Cardiology, San Diego, CA Mar 2015.

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Last updated: 05/24/2017
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