Paschalis-Thomas Doulias, PhD

faculty photo
Research Assistant Professor of Pediatrics
Department: Pediatrics

Contact information
Children’s Hospital of Philadelphia Research Institute
416D Abramson Center
34th Street and Civic Center Boulevard
Philadelphia, PA 19104
Fax: (215) 590-4267
Lab: (215) 590-5319
BS (Chemistry)
University of Ioannina, Greece, 1998.
PhD (Biological Chemistry)
Medical School, University of Ioannina, Greece, 2005.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Selected Publications

Urbano R., Karlinsey J.E. , Stephen J. Libby S.J., Doulias PT, Harry Ischiropoulos H., Helen I. Warheit-Niemi H.I., Liggitt D.H., Alexander R. Horswill A.R., Ferric C. Fang F.C.: Host Nitric Oxide Disrupts Microbial Cell-to-Cell Communication to Inhibit Staphylococcal Virulence. Cell Host and Microbe 2018.

Doulias P-T, Tenopoulos M, Zura G, Nakamoto K, Faust M, Li L, Ischiropoulos H: Bioactive nitric oxide for metabolic syndrome. Poster presentation, Cell Symposia: Metabolic Disease Therapies, San Diego, CA Oct 2017.

Lin W, Vann DR, Doulias PT, Wang T, Landesberg G, Li X, Ricciotti E, Scalia R, He M, Hand NJ,Daniel J, Rader DJ: Hepatic SLC39A8/ZIP8 regulates whole-body manganese homeostasis and the activity of Mn-dependent enzymes. J Clin Invest 127(6): 2407-2417, June 2017 Notes: DOI: 10.1172/JCI90896.

Zamani P, Tan VX, Soto-Calderon H, Beraun M, Brandimarto J, Trieu L, Varakantam S, Doulias PT, Townsend RR, Chittams J, Margulies KB, Cappola TP, Poole DC, Ischiropoulos H, Chirinos JA: Pharmacokinetics and Pharmacodynamics of Inorganic Nitrate in Heart Failure With Preserved Ejection Fraction. Circ Res 120(7): 1151-1161, Mar 2017.

Zamani P, French B, Brandimarto JA, Doulias PT, Javaheri A, Chirinos JA, Margulies KB, Townsend RR, Sweitzer NK, Fang JC, Ischiropoulos H, Cappola TP: Effect of Heart Failure With Preserved Ejection Fraction on Nitric Oxide Metabolites. Am J Cardiol 118(15): 1855-1860, Dec 2016.

Chirinos JA, Akers SR, Trieu L, Ischiropoulos H, Doulias PT, Tariq A, Vassim I, Koppula MR, Syed AA, Soto-Calderon H, Townsend RR, Cappola TP, Margulies KB, Zamani P: Heart Failure, Left Ventricular Remodeling, and Circulating Nitric Oxide Metabolites. J Am Heart Assoc 5(10): e004133, Oct 2016.

Trieu L, Zamani P, Tran V, Soto-Calderon H, Beraun M, Brandimarto JA, Varakantam S, Paschalis-Thomas Doulias P-T, Townsend RR, Chittams J, Margulies KB, Cappola TP, Poole DC, Ischiropoulos H, Chirinos JA. : Inorganic Nitrate Does Not Worsen Physical Activity. Journal of Cardiac Failure. Poster presentation, Proceedings of the 20th Annual Scientific Meeting of The Heart Failure Society of America (HSFA), Gaylord Palms, FL Sep-Oct 2016.

Chen F, Wang Y, Rafikov R, Haigh S, Zhi WB, Kumar S, Doulias PT, Rafikova O, Pillich H, Chakraborty T, Lucas R, Verin AV, Catravas JD, She JX, Black SM, Fulton D Jr: RhoA S-nitrosylation as a regulatory mechanism influencing endothelial barrier function in response to G+-bacterial toxins. Biochem Pharmacol 127: 34-45, 2016.

Irie T, Sips PY, Kai S, Kida K, Ikeda K, Hirai S, Moazzami K, Jiramongkolchai P, Bloch DB, Doulias PT, Armoundas AA, Kaneki M, Ischiropoulos H, Kranias E, Bloch KD, Stamler J, Ichinose F: S-Nitrosylation of Calcium-Handling Proteins in Cardiac Adrenergic Signaling and Hypertrophy. Circ Res 117(9): 793-803, Oct 2015.

Raju K, Doulias PT, Evans P, Krizman EN, Jackson JG, Horyn O, Daikhin Y, Nissim I, Yudkoff M, Nissim I, Sharp KA, Robinson MB, Ischiropoulos H : Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation. Science Sig 8(384): ra68, Jul 2015.

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Last updated: 06/21/2018
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