Rizwan S Akhtar, MD, PhD

faculty photo
Assistant Professor of Neurology at the Pennsylvania Hospital
Department: Neurology

Contact information
330 South 9th St, Fourth Floor
Penn Neurological Institute
Philadelphia, PA 19107
Office: 2158296500
Fax: 2158296606
BS (Molecular Biology / Psychology)
Vanderbilt University, 2000.
MD (Medicine)
University of Alabama at Birmingham, 2007.
PhD (Neurobiology)
University of Alabama at Birmingham, 2007.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Clinical Expertise

Movement disorders, including Parkinson's disease, atypical parkinsonism, dystonia, ataxia, blepharospasm, and essential tremor.

Description of Research Expertise

Development of α-synuclein and amyloid-β biomarkers for Parkinson's disease and related neurodegenerative diseases.

Selected Publications

Irwin DJ, Xie SX, Coughlin D, Nevler N, Akhtar RS, McMillan CT, Lee EB, Wolk DA, Weintraub D, Chen-Plotkin AS, Duda JE, Spindler M, Siderowf AD, Hurtig HI, Shaw LM, Grossman M, Trojanowski JQ: CSF tau and amyloid-β predict cerebral synucleinopathy in autopsied Lewy Body disorders. Neurology 90(12): e1038-e1046, Mar 2018 Notes: doi: 10.1212/WNL.0000000000005166.

Akhtar RS, Licata JP, Luk KC, Shaw LM, Trojanowski JQ, Lee VM.: Measurements of auto-antibodies to α-synuclein in the serum and cerebral spinal fluids of patients with Parkinson's disease. Journal of Neurochemistry 145(6): 489-503, Jun 2018 Notes: doi: 10.1111/jnc.14330.

Covell DJ, Robinson JL, Akhtar RS, Grossman M, Weintraub D, Bucklin HM, Pitkin RM, Riddle D, Yousef A, Trojanowski JQ, and Lee VM: Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson’s disease. Neuropathology and Applied Neurobiology 43(7): 604-620, Dec 2017 Notes: doi: 10.1111/nan.12402.

Akhtar RS, Licata JP, Luk KC, Covell DJ, Trojanowski JQ, Lee VM: Epitope mapping of CSF auto-antibodies to α-synuclein. Movement Disorders 32(suppl 2): S231, Jun 2017.

Akhtar RS, Xie SX, Chen YJ, Rick J, Gross RG, Nasrallah IM, Van Deerlin VM, Trojanowski JQ, Chen-Plotkin AS, Hurtig HI, Siderowf AD, Dubroff JG, Weintraub D: Regional brain amyloid-β accumulation associates with domain-specific cognitive performance in Parkinson disease without dementia. PLoS One 12(5): e0177924, May 2017 Notes: doi:10.1371/pone.0177924.

Akhtar RS, Xie SX, Brennan L, Pontecorvo MJ, Hurtig HI, Trojanowski JQ, Weintraub D, and Siderowf AD: Amyloid-β PET imaging of Alzheimer pathology in Parkinson disease dementia. Movement Disorders Clinical Practice 3(4): 367-375, Jul-Aug 2016.

Pigott K, Rick J, Xie SX, Hurtig HI, Chen-Plotkin AS, Duda JE, Morley JF, Chahine LM, Dahodwala N, Akhtar RS, Siderowf AD, Trojanowski JQ, and Weintraub D: Longitudinal study of normal cognition in Parkinson’s Disease. Neurology 85(15): 1276-1282, Oct 2015.

Akhtar RS, Stern MB: New concepts in the early and preclinical detection of Parkinson's disease: therapeutic implications. Expert Review of Neurotherapeutics 12(12): 1429-1438, Dec 2012.

Akhtar RS, Horn SS: Psychiatric manifestations of common neurologic disorders. Principles and Practice of Geriatric Psychiatry 2 ed. Agronin ME, Maletta GJ (eds.). Lippincott, Williams & Wilkins, Philadelphia, Pennsylvania, Page: 735-744, 2011.

Akhtar RS, Latham CB, Siniscalco D, Fuccio C, Roth KA: Immunohistochemical detection with quantum dots. Methods in Molecular Biology. Hotz C, Bruchez Jr. M (eds.). Humana Press, Totowa, New Jersey, 374: 11-28, 2007.

Akhtar RS, Klocke BJ, Strasser A, Roth KA: Loss of BH3-only protein Bim inhibits apoptosis of hemopoietic cells in the fetal liver and male germ cells but not neuronal cells in bcl-x-deficient mice. Journal of Histochemistry and Cytochemistry 56(10): 921-927, Oct 2008.

Akhtar RS, Geng Y, Klocke BJ, Roth KA: Neural precursor cells possess multiple p53-dependent apoptotic pathways. Cell Death and Differentiation 13(10): 1727-1739, Oct 2006.

Akhtar RS, Roth KA: Regulation of neural stem cell death. Neural Development and Stem Cells 2 ed. Rao MS (eds.). Humana Press, Totowa, New Jersey, Page: 97-122, 2006.

Akhtar RS, Geng Y, Klocke BJ, Latham CB, Villunger A, Michalak EM, Strasser A, Carroll SL, Roth KA: BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death. The Journal of Neuroscience 26(27): 7257-7264, Jul 2006.

Ness JM, Akhtar RS, Latham CB, Roth KA: Combined tyramide signal amplification and quantum dots for sensitive and photostable immunofluorescence detection. Journal of Histochemistry and Cytochemistry 51(8): 981-987, Aug 2003.

Akhtar RS, Ness JM, Roth KA: Bcl-2 family regulation of neuronal development and neurodegeneration. Biochimica et Biophysica Acta 1644(2-3): 189-203, Mar 2004.

back to top
Last updated: 12/18/2018
The Trustees of the University of Pennsylvania