Krzysztof Laudanski, MD, PhD, MA, FCCM
3620 Hamilton Walk
Philadelphia, PA 19104
Lab: +1 (215) 746-1398
The Warsaw Medical University, 1998.
The Warsaw University, 2000.
The Warsaw University, 2001.
Ph.D. (Anesthesiology & Immunology)
The Military Institute of Medicine, 2012.
M.H.I. (Health Innovation)
The University of Pennsylvania, 2020.
Description of Clinical ExpertiseKrzysztof “Kris” Laudanski, MD is an Assistant Professor of the Department of Anesthesiology and Critical Care at the University of Pennsylvania. He is board certified in both anesthesiology and critical care physician. He is the Fellow of Critical Care, an award given by the Society of Critical Care Medicine. He splits his practice between Heart & Vascular, Trauma and Neuro Intensive Care Unit. His clinical experience focuses on managing ECMO, VAD, post-operative recovery, sepsis, and post-operative cognitive decline. He holds the Regional Anesthesia Certificate by the American Association of Anesthesiologists.
Description of Other ExpertiseDr. Laudanski lectures on the subjects of medical decision making, ECMO and sepsis. However, his passion is providing support to future generations of medical professionals. Being a mentor is creative and fulfilling work that begins with creating a tailored plan that fits both the mentee’s and mentor’s interests, goals and passion. Dr. Laudanski provides a mentee an opportunity to focus her research in the clinical setting, analyzing data from charts or in the lab, or conducting bench-side work in molecular biology. He is part of the CURF program at the University of Pennsylvania. He is also mentoring three PhD students, and advises several junior investigators. His past mentees work at various academic positions (Stanford, Yale), private companies (Merck), or were awarded prestigious scholarships (NSF).
Description of Research ExpertiseDr. Laudanski's research focuses on the three distinctive areas: regulation of DNA expression in survivors after critical care illnesses, health care operations/medical decision making processes, and medical volunteerism. On the first subject, he is a PI on the NIH-funded project focusing on the long-term regulation of gene expression after a critical care event and the impact on the recovery of the patient after critical care illness and anesthesia/surgery. He is also very interested in medical decision making and health care operations as the primary determinant of patient recovery. His research investigates the cognitive process, biases and the effect of emotional imprints on the decisions made by medical professionals. His work showed that suboptimal decision making processes may expose patients to unnecessary risk and have negative economic consequences for hospital systems. Optimizing health care in the ICU is another area of interest. The ICU environment is demanding with significant swings in demand. Improving existing health care models, or envisioning new health care models, may have a potentially significant impact on individual and population health. Dr. Laudanski is particularly interested in tele-ICU, especially in terms of integration with wearable devices and alternative models of health care delivery. He uses simulation, narrative studies, and cognitive testing to discover operating problems and provide the staff with unique experiences. Finally, adjusting health care operations and delivery based on the availability, cultural specificity, and local demands is another area of interest that is frequently pursued by Kris in the austere and remote settings.
Selected PublicationsLaudanski K, Zawadka M, Polosak J, Modi J, DiMeglio M, Gutsche J, Szeto WY, Puzianowska-Kuzmicka M : Acquired immunological imbalance after surgery with cardiopulmonary bypass due to to epigenetic over-activation of PU.1/M-CSF. Journal of Translational Medicine 143(16): 1-13, May 2018 Notes: corresponding and first author.
Laudanski K, Lapko N, Zawadka M, Danet-Desnoyer G, Worthen GS: The clinical and immunological performance of 28 days survival model of cecal ligation and puncture in humanized mice. PLoS One 12(7): e0180377, Jul 2017.
Lapko N, Zawadka M, Polosak J, Worthen GS, Danet-Desnoyers G, Puzianowska-Kuzmicka M, Laudanski K : Long-term monocyte dysfunction after sepsis in humanized mice is related to persisted activation of M-CSF and demethylation of PU.1 and it can be reversed by blocking M-CSF in vitro or by transplanting naïve autologous stem cells in vivo Frontiers in Immunology 8: 401-412, 2017.
Zawadka M, Wahome J, Oszkiel H, Szeto WY, Cobb B, Laudanski K: Long-term alterations in monocyte function after elective cardiac surgery Anaesthesia 72(7): 879-888, Jul 2017.
Laudanski K, Miller-Graziano C, Xiao W, Mindrinos MN, Richards DR, De A, Moldawer LL, Maier RV, Bankey P, Baker HV, Brownstein BH, Cobb JP, Calvano SE, Davis RW, Tompkins RG: Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways. Proceedings of the National Academy of Sciences of the United States of America 103(42): 15564-15569, Oct 2006.
Laudanski K, Eckenhoff R: Anesthesia-induced neuroinflammation. Journal of Anesthesia and Peri-Operative Medicine 1(2): 120-124, 2014.
Laudanski K, Qing M, Zawadka M, Oszkiel H, Lapko N, Nowak Z, Worthen SG: Ketamine affects the differentiation of monocytes into immature dendritic cells via Transforming Growth Factor. Anesthesiology 123(3): 628-641, Sep 2015.
Joseph T, DiMeglio M, Huffenberger, Laudanski K: Electrolyte Repletion in Intensive Care Units. Anesthesia & Analgesia 124(4), 2018 Notes: Annual Meeting. The International Anesthesia Research Society.
Laudanski K, Valagapudi V: ICU Capacity Strain: The need for standardization of definitions. Critical Care Connection Page: 14, June/July 2018.
Pieczynski LM, Laudanski K, Speck RM, McCunn M: Analysis of field reports from anaesthesia volunteers in low- to middle-income countries. Medical Education 47(10): 1029-1036, Oct 2013.