Krzysztof Laudanski, MD, PhD, MA, FCCM, MHCI

faculty photo
Assistant Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania
Department: Anesthesiology and Critical Care

Contact information
JMB 127
3620 Hamilton Walk
Philadelphia, PA 19104
Office: +1 (352) 222-5202
Lab: +1 (215) 746-1398
Education:
M.D. (Medicine)
The Warsaw Medical University, 1998.
B.Sc (Psychology)
The Warsaw University, 2000.
M.A (Psychology)
The Warsaw University, 2001.
Ph.D. (Anesthesiology & Immunology)
The Military Institute of Medicine, 2012.
MHCI (Healthcare Innovation)
The University of Pennsylvania, 2020.
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Description of Clinical Expertise

I split my medical practice between working in the Neuro, Heart & Vascular, Neuro, and Trauma Intensive Care Unit. Sine 2012 I accumulated a rich experience in managing patients using remote means by working at Penn eLert, a tele-ICU part of the PennMedicine. I provide anesthesia in various settings. I also hold the Regional Anesthesia Certificate by the American Association of Anesthesiologists. I am Board certified in Anesthesiology and Critical Care.

My clinical experience focuses on managing ECMO, VAD, postoperative recovery, sepsis, postoperative cognitive decline, and telemedicine. Since my fellowship at the BIDMC bedside ultrasonography is an important part of my clinical toolbox.

Description of Other Expertise

Dr. Laudanski lectures on the subjects of medical decision making, ECMO and sepsis. However, his passion is providing support to future generations of medical professionals. Being a mentor is creative and fulfilling work that begins with creating a tailored plan that fits both the mentee’s and mentor’s interests, goals and passion. Dr. Laudanski provides a mentee an opportunity to focus her research in the clinical setting, analyzing data from charts or in the lab, or conducting bench-side work in molecular biology. He is part of the CURF program at the University of Pennsylvania. He is also mentoring three PhD students, and advises several junior investigators. His past mentees work at various academic positions (Stanford, Yale), private companies (Merck), or were awarded prestigious scholarships (NSF).

Description of Research Expertise

Immune system abnormalities are the focus of my research. I am particularly interested in the performance of the immune system long-term. I believe passionately that after any severe critical care insult, the immune system in certain individuals has a long-term and persistent aberration in the function of the immune system. It is possible that the immune system never goes back to its original performance. Instead, a new state of immunostasis emerges that is mediated by changes in the regulation of DNA expression. This notion is of great importance for my clinical practice. As a critical care physician, I believe that my mission is to reunite my patients with family and life in a meaningful way.

I focus on abnormalities in monocytes, lack of dendritic cells, and T cell anergy in patients after burn, trauma cancer, surgery, or COVID-19. I demonstrated the emergence of several immune system abnormalities in the wakes of the critical care illness even in seemingly recovered individuals.

My lab utilizes a variety of techniques from DNA, RNA, protein, and functional assays. The majority of my research involves individuals with sepsis, undergoing cardiac surgery or experiencing neurotrauma. I also worked in humanized mice models or Drosophila.

Selected Publications

Laudanski K, Zawadka M, Polosak J, Modi J, DiMeglio M, Gutsche J, Szeto WY, Puzianowska-Kuzmicka M : Acquired immunological imbalance after surgery with cardiopulmonary bypass due to to epigenetic over-activation of PU.1/M-CSF. Journal of Translational Medicine 143(16): 1-13, May 2018 Notes: corresponding and first author.

Laudanski K, Lapko N, Zawadka M, Danet-Desnoyer G, Worthen GS: The clinical and immunological performance of 28 days survival model of cecal ligation and puncture in humanized mice. PLoS One 12(7): e0180377, Jul 2017.

Lapko N, Zawadka M, Polosak J, Worthen GS, Danet-Desnoyers G, Puzianowska-Kuzmicka M, Laudanski K : Long-term monocyte dysfunction after sepsis in humanized mice is related to persisted activation of M-CSF and demethylation of PU.1 and it can be reversed by blocking M-CSF in vitro or by transplanting naïve autologous stem cells in vivo Frontiers in Immunology 8: 401-412, 2017.

Zawadka M, Wahome J, Oszkiel H, Szeto WY, Cobb B, Laudanski K: Long-term alterations in monocyte function after elective cardiac surgery Anaesthesia 72(7): 879-888, Jul 2017.

Laudanski K, Miller-Graziano C, Xiao W, Mindrinos MN, Richards DR, De A, Moldawer LL, Maier RV, Bankey P, Baker HV, Brownstein BH, Cobb JP, Calvano SE, Davis RW, Tompkins RG: Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways. Proceedings of the National Academy of Sciences of the United States of America 103(42): 15564-15569, Oct 2006.

Laudanski K, Eckenhoff R: Anesthesia-induced neuroinflammation. Journal of Anesthesia and Peri-Operative Medicine 1(2): 120-124, 2014.

Laudanski K, Qing M, Zawadka M, Oszkiel H, Lapko N, Nowak Z, Worthen SG: Ketamine affects the differentiation of monocytes into immature dendritic cells via Transforming Growth Factor. Anesthesiology 123(3): 628-641, Sep 2015.

Joseph T, DiMeglio M, Huffenberger, Laudanski K: Electrolyte Repletion in Intensive Care Units. Anesthesia & Analgesia 124(4), 2018 Notes: Annual Meeting. The International Anesthesia Research Society.

Laudanski K, Valagapudi V: ICU Capacity Strain: The need for standardization of definitions. Critical Care Connection Page: 14, June/July 2018.

Pieczynski LM, Laudanski K, Speck RM, McCunn M: Analysis of field reports from anaesthesia volunteers in low- to middle-income countries. Medical Education 47(10): 1029-1036, Oct 2013.

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Last updated: 04/17/2021
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