Ganesh S. Moorthy, PhD

faculty photo
Research Assistant Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care

Contact information
Children's Hospital of Philadelphia
Department of Anesthesiology and Critical Care Medicine
Bioanalytical Core Laboratory, The Center for Clinical Pharmacology
516A Abramson Pediatric Research Center
3615 Civic Center Blvd
Philadelphia, PA 19104
Office: 215 590 0142
Fax: 267 425 0025
Lab: 215 590 0142
Education:
BSc (Chemistry)
Bharathiyar University, Coimbatore, India , 1988.
MSc (Chemistry)
Indian Institute of Technology, Madras, India , 1990.
PhD (Chemistry)
Case Western Reserve University, 1997.
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Description of Clinical Expertise

Watson LIMS, PK sample collection kits, biorepository, and sample analysis.

Description of Other Expertise

Drug Discovery, Pharmacokinetics and Translational Research

Description of Research Expertise

Bioanalytical Chemistry and Clinical Pharmacology

The primary focus of my research is working with physicians and scientists to solve complex problems in pediatric drug development. Our laboratory is equipped with UPLC-MS/MS and UHPLC-MS/MS systems and Watson LIMS. We specialize in the development and validation of analytical methods and their implementation for pediatric and adult clinical sample analysis. Our clinical research is focused on the pharmacokinetic analysis of dexmedetomidine, midazolam, morphine, ketamine, cefepime, cefazolin, voriconazole, efavirenz, tenofovir,vancomycin and cannabinoids. We also have an expertise in the fast assay development for preclinical studies in various biological matrices. Our preclinical research involves the pharmacokinetic analysis of oxycodone, SN-38, irinotecan, vemurafenib, and secoisolariciresinol diglucoside. We continue to evaluate and utilize new tools and microsampling technologies to facilitate preclinical, translational and clinical research.

Selected Publications

Moorthy GS, Vedar C, Downes KJ, Fitzgerald JC, Scheetz MH, Zuppa AF.: Microsampling Assays for Pharmacokinetic Analysis and Therapeutic Drug Monitoring of Antimicrobial Drugs in Children: A Critical Review. Ther Drug Monit. Dec 2020 Notes: doi: 10.1097/FTD.0000000000000845. Online ahead of print.

Moorthy GS, Downes KJ, Vedar C, and Zuppa AF: A whole blood microsampling assay for vancomycin: Development, validation and application for pediatric clinical study. Bioanalysis Sep 2020.

Moorthy GS, Vedar C, Zane NR, Downes KJ, Zuppa AF: Development, validation and implementation of patient-centric Volumetric absorptive microsampling-LC-MS/MS assays for the analysis of anti-bacterial drugs in pediatric subject. American Society for Mass Spectrometry Annual Conference Jun 2020 Notes: Poster Presentation, Online.

Vedar C, Moorthy GS, Downes KJ, Zuppa AF: A microsampling Assay for the quantitation of vancomycin in human whole blood. American Society for Mass Spectrometry Annual Conference Jun 2020 Notes: Poster Presentation, Online.

Pais GM, Liu J, Zepcan S, Avedissian SN, Rhodes NJ, Downes K, Moorthy GS, Scheetz MH: Vancomycin induced kidney injury: Animal models of toxicodynamics, mechanisms of injury, human translation, and potential strategies for prevention. Pharmacotherapy 40(5): 438-454, May 2020.

Zanni G, DeSallea MJ, Deutscha HM, Barr GA, Eisch AJ: Female and male rats readily consume and prefer oxycodone to water in a chronic, continuous access, two-bottle oral voluntary paradigm. Neuropharmacology 167(5): 107978, May 2020.

Lalley-Chareczko L, Hiserodt E, Moorthy GS, Zuppa AF, Mounzer K, Koenig HC: Urine Assay to Measure Tenofovir Concentrations in Patients Taking Tenofovir Alafenamide. Frontiers in Pharmacology 11: 286, March 2020.

Moorthy GS, Vedar C, Zane NR, Downes KJ, Prodell JL, DiLiberto MA, Zuppa AF: Development and validation of a volumetric absorptive microsampling- liquid chromatography mass spectrometry method for the analysis of cefepime in human whole blood: Application to Pediatric Pharmacokinetic Study. Journal of Pharmaceutical and Biomedical Analysis 5(179): 113002, Feb 2020.

Moorthy GS, Lalley-Chareczko L, Koenig HC, Zuppa AF: Tenofovir urine assay to monitor adherence to HIV pre-exposure prophylaxis (PrEP). Curr Clin Pharmacol 15(2): 102-104, 2020.

Moorthy GS, Vedar C, DiLiberto MA, Zuppa AF: A patient-centric liquid chromatography-tandem mass spectrometry microsampling assay for analysis of cannabinoids in human whole blood: Application to pediatric pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci 1130-1131: 121828, Nov 2019.

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Last updated: 02/01/2021
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