Ganesh S. Moorthy, PhD

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Research Assistant Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care

Contact information
The Children's Hospital of Philadelphia
Department of Anesthesiology and Critical Care Medicine
Bioanalytical Core Laboratory, The Center for Clinical Pharmacology
4012 Colket Translational Research Building
3501 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215 590 0142
Fax: 267 425 0025
Lab: 215 590 0142
Education:
B.Sc. (Chemistry)
Bharathiyar University, Coimbatore, India , 1988.
M.Sc. (Chemistry)
Indian Institute of Technology, Madras, India , 1990.
Ph.D. (Chemistry)
Case Western Reserve University, 1997.
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Description of Clinical Expertise

Experienced in preparing PK sample collection kits, management, analysis, and biorepository.

Description of Other Expertise

Drug Discovery, Drug Metabolism and Pharmacokinetics

Description of Research Expertise

Bioanalytical Chemistry and Clinical Pharmacology

The primary focus of my research is working with physicians and scientists to solve complex problems in pediatric drug development. Our laboratory is equipped with UPLC-MS/MS and UHPLC-MS/MS systems and Watson LIMS. We specialize in the development and validation of analytical methods and their implementation for pediatric and adult clinical sample analysis. Our clinical research is focused on the pharmacokinetic analysis of dexmedetomidine, midazolam, morphine, ketamine, cefepime, cefazolin, voriconazole, efavirenz, tenofovir,vancomycin and cannabinoids. We also have an expertise in the fast assay development for preclinical studies in various biological matrices. Our preclinical research involves the pharmacokinetic analysis of oxycodone, SN-38, irinotecan, vemurafenib, and secoisolariciresinol diglucoside. We continue to evaluate and utilize new tools and microsampling technologies to facilitate preclinical, translational and clinical research.

Selected Publications

Busch CM, Desai AV, Moorthy GS, Fox E, Balis FM: A validated HPLC-MS/MS method for estimating the concentration of the ganglioside, GD2, in human plasma or serum J Chromatogr B Analyt Technol Biomed Life Sci. 1102-1103: 60-65, Dec 1 2018.

Zuppa, AF; Zane, NR; Moorthy, G; Dalton, HJ; Abraham, A; Reeder, RW; Carcillo, JA; Yates, AR; Meert, KL; Berg, RA; Sapru, A; Mourani, P; Notterman, DA; Dean, JM; Gastonguay, MR for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN: A Population Pharmacokinetic Analysis to Study the Effect of Extracorporeal Membrane Oxygenation on Cefepime Disposition in Children Pediatric Critical Care Medicine P, November 2018 Notes: doi: 10.1097/PCC.0000000000001786.

Lalley-Chareczko L, Clark D, Conyngham C, Zuppa A, Moorthy G, Mounzer K, Koenig H: Delivery of TDF/FTC for Pre-exposure Prophylaxis to Prevent HIV-1 Acquisition in Young Adult Men Who Have Sex With Men and Transgender Women of Color Using a Urine Adherence Assay. J Acquir Immune Defic Syndr. 79(2): 173-178, Oct 2018.

Adam A, Vedar C, Moorthy GS, Prodell JL, DiLiberto MA, and Zuppa AF. : Sensitivity Enhancement for the Quantitation of Three Cannabinoids by Volumetric Absorptive Microsampling in Human Whole Blood. CPSA Oct 2018 Notes: Poster presentation at the Clinical and Pharmaceutical Solutions through Analysis USA, Langhorne, PA, October 15-18, 2018.

Moorthy AS, Vedar C, Moorthy GS, Villanueve J, Winkler JD, Marmorstein R, and Zuppa AF. : An ultra-performance liquid chromatography-tandem mass spectrometric method for the quantitation of vemurafenib and vem-BisAmide-2 in small volume of mouse plasma: Application to mouse pharmacokinetic study. CPSA Oct 2018 Notes: Poster presentation at the Clinical and Pharmaceutical Solutions through Analysis USA, Langhorne, PA, October 15-18, 2018.

Shah N, Cohen A, Vedar C, Moorthy GS, DiLiberto MA, and Zuppa AF. : Development of LC-MS/MS Method for Analysis of Oxycodone in Small Volume of Rat Plasma and Rat Serum, Plasma and Aqueous Buffers. CPSA Oct 2018 Notes: Poster presentation at the Clinical and Pharmaceutical Solutions through Analysis USA, Langhorne, PA, October 15-18, 2018.

Vedar C, Moorthy GS, Adam A, and Zuppa AF. : Bioanalytical Method Validation for Cefepime in Human Plasma: Stability of Cefepime in Blood, Dried Blood Spot, Volumetric Absorptive Microsampling, Plasma and Aqueous Buffers. CPSA Oct 2018 Notes: Poster presentation at Clinical and Pharmaceutical Solutions through Analysis USA, Langhorne, PA, October 15-18.

Moorthy GS, Vedar C, Moorthy AS, Prodell JL, and Zuppa AF. : An improved liquid chromatography-tandem mass spectrometric method for the quantitation of dexmedetomidine in small volume of pediatric plasma. Clinical Pharmacology in Drug Development 7(S1): 25, Sep 2018 Notes: Poster presentation (Number 028) at the American College of Clinical Pharmacology Annual Meeting, Bethesda, MD, September 23 - 25, 2018.

Vedar C, Moorthy GS*, Zane NR, Prodell JL, and Zuppa AF.: Assay for Bergamottin and 6,7-Dihydroxybergamottin in Grapefruit Juice and a Microsampling Assay for Analysis of Voriconazole and Voriconazole N-Oxide in Human Whole Blood. Clinical Pharmacology in Drug Development 7(S1): 29-31, Sep 2018 Notes: Poster presentation (Number 034) at the American College of Clinical Pharmacology Annual Meeting, Bethesda, MD, September 23 - 25, 2018. *Presenting Author.

DiLiberto MA, Prodell JL, Moorthy GS, Vedar C, Irizarry J, and Zuppa AF. : Implementation of a Pediatric Medical Cannabis Research Program. Clinical Pharmacology in Drug Development 7(S1): 64, Sep 2018 Notes: Poster presentation (number 079)at the American College of Clinical Pharmacology Annual Meeting, Bethesda, MD, September 23 - 25, 2018.

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Last updated: 11/16/2018
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