Ganesh S. Moorthy, Ph.D.

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Research Assistant Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care

Contact information
The Children's Hospital of Philadelphia
Department of Anesthesiology and Critical Care Medicine
Bioanalytical Core, Center for Clinical Pharmacology
4012 Colket Translational Research Building
3501 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215 590 0142
Education:
B.Sc. (Chemistry)
Bharathiyar University, Coimbatore, India , 1988.
M.Sc. (Chemistry)
Indian Institute of Technology, Madras, India , 1990.
Ph.D. (Chemistry)
Case Western Reserve University, 1997.
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Description of Research Expertise

Bioanalytical Chemistry and PK/PD Analysis

The primary focus of my research is working with physicians and scientists to solve complex problems in pediatric drug development. Our laboratory is equipped with UPLC-MS/MS systems and Watson LIMS. We specialize in method development, validation and sample analysis for pediatric and adult clinical trials. We also have an expertise in the fast assay development for preclinical studies in various biological matrices. We continue to evaluate and utilize new tools and microsampling technologies to facilitate preclinical, translational and clinical research.

Selected Publications

Moorthy GS, Giaccone A, Zuppa AF. : Development and validation of a sensitive LC-MS/MS method for analysis of milrinone in pediatric plasma. American Society of Mass Spectrometry annual meeting, 04 June 2017, Indianapolis, IN (oral presentation). June 2017.

Vujkovic M, Bellamy SL, Zuppa AF, Gastonguay M, Moorthy GS, Ratshaa BR, Han X, Steenhoff AP, Mosepele M, Strom BL, Aplenc R, Bisson GP, Gross R.: CYP2B6 516G>T Minor Allele Protective of Late Virologic Failure in Efavirenz-treated HIV-Infected Patients in Botswana. J Acquir Immune Defic Syndr. May 2017 Notes: [Epub ahead of print]

Koenig HC, Mounzer K, Daughtridge GW, Sloan CE, Lalley-Chareczko L, Moorthy GS, Conyngham SC, Zuppa AF, Montaner LJ, Tebas P. : Urine assay for tenofovir to monitor adherence in real time to tenofovir disoproxil fumarate/emtricitabine as pre-exposure prophylaxis. HIV Med. April 2017 Notes: [Epub ahead of print]

Lalley-Chareczko L, Clark D, Zuppa AF, Moorthy G, Conyngham C, Mounzer K, Koenig H.: A case study of chewed Truvada® for PrEP maintaining protective drug levels as measured by a novel urine tenofovir assay. Antivir Ther. March 2017 Notes: [Epub ahead of print]

Busch CM, Desai AV, Moorthy GS, Fox E, Balis F.: A validated LC-MS/MS assay to measure ganglioside GD2 as a biomarker for childhood neuroblastoma. American Society for Clinical Pharmacology and Therapeutics (ASCPT) Annual Meeting, Late-breaking Poster Session. March 15-18, 2017, Washington DC Poster # LB-18, March 2017.

Moorthy GS, Jogiraju H, Vedar C, Zuppa AF. : Bioanalytical Core Laboratory: Expertise, Services and Resources. CHOP Research Poster Day Expo February 2017 Notes: February 22, 2017.

Lally-Charezko L, Clark D, Moorthy GS, Zuppa AF, Conyngham C, Mounzer K, Tebas P, Koenig HC: Urine tenofovir testing to measure prep adherence amount youth in a real world setting. Conference on Retroviruses and Opportunistic Infections (CROI) February 2017 Notes: Poster Presentation.

Giaccone A, Zuppa AF, Sood B, Cohen M, O’Byrne M, Moorthy GS, Mathur A, Kirpalani H. : Milrinone Pharmacokinetics and Pharmacodynamics in Neonates with Persistent Pulmonary Hypertension of the Newborn. Am J Perinatol. Page: doi: 10.1055/s-0036-1597996. January 2017 Notes: [Epub ahead of print]

Vujkovic M, Bellamy SL, Zuppa AF, Gastonguay M, Moorthy GS, Ratshaa BR, Han X, Steenhoff AP, Mosepele M, Strom BL, Bisson GP, Aplenc R, Gross R.: Polymorphisms in Cytochrome P450 are associated with Extensive Efavirenz Pharmacokinetics and Neuropsychiatric Toxicities in an HIV Cohort in Botswana. PLOS ONE (submitted) 2017.

Elia J, Jones G, Kao C, Ambrosini A, De Jesus-Rosario N, Larsen L, Chiavacci R, Wang T, Kurian C, Titchen K, Sykes B, Hwan S, Kumar B, Potts J, Davis J, Malatack J, Slattery E, Moorthy GS, Zuppa AF, Weller A, Byrne G, Li YR, Kraft WK, Hakonarson H.: Effects of NFC-1 in ADHD Adolescents Harboring Glutamatergic Gene Network Variants Disrupting mGluR Neurotransmitter Signaling. Nature Communications (submitted) 2017.

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Last updated: 05/26/2017
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