Dwight Gary Gilliland, MD, PhD

faculty photo
Department: Medicine

Contact information
Precision Medicine
Abramson Family Cancer Research Institute
Perelman School of Medicine, University of Pennsylvania
557 BRB II/III
421 Curie Boulevard
Philadelphia, PA 19104-6160
Education:
BS (Bacteriology)
University of California, Davis , 1975.
PhD (Microbiology)
University of California, Los Angeles , 1980.
MD (Internal Medicine)
University of California, San Francisco, 1984.
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Selected Publications

Guertin Amy D, Li Jing, Liu Yaping, Hurd Melissa S, Schuller Alwin G, Long Brian, Hirsch Heather A, Feldman Igor, Benita Yair, Toniatti Carlo, Zawel Leigh, Fawell Stephen E, Gilliland D Gary, Shumway Stuart D: Preclinical evaluation of the WEE1 inhibitor MK-1775 as single-agent anticancer therapy. Molecular cancer therapeutics 12(8): 1442-52, Aug 2013.

Morris Erick J, Jha Sharda, Restaino Clifford R, Dayananth Priya, Zhu Hugh, Cooper Alan, Carr Donna, Deng Yongi, Jin Weihong, Black Stuart, Long Brian, Liu Jenny, Dinunzio Edward, Windsor William, Zhang Rumin, Zhao Shuxia, Angagaw Minilik H, Pinheiro Elaine M, Desai Jagdish, Xiao Li, Shipps Gerald, Hruza Alan, Wang James, Kelly Joe, Paliwal Sunil, Gao Xiaolei, Babu Boga Sobhana, Zhu Liang, Daublain Pierre, Zhang Ling, Lutterbach Bart A, Pelletier Marc R, Philippar Ulrike, Siliphaivanh Phieng, Witter David, Kirschmeier Paul, Bishop W Robert, Hicklin Daniel, Gilliland D Gary, Jayaraman Lata, Zawel Leigh, Fawell Stephen, Samatar Ahmed A: Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. Cancer discovery 3(7): 742-50, Jul 2013.

Tam Winnie F, Hähnel Patricia S, Schüler Andrea, Lee Benjamin H, Okabe Rachel, Zhu Nan, Pante Saskia V, Raffel Glen, Mercher Thomas, Wernig Gerlinde, Bockamp Ernesto, Sasca Daniel, Kreft Andreas, Robinson Gertraud W, Hennighausen Lothar, Gilliland D Gary, Kindler Thomas: STAT5 is crucial to maintain leukemic stem cells in acute myelogenous leukemias induced by MOZ-TIF2. Cancer research 73(1): 373-84, Jan 2013.

Kalaitzidis Demetrios, Sykes Stephen M, Wang Zhu, Punt Natalie, Tang Yuefeng, Ragu Christine, Sinha Amit U, Lane Steven W, Souza Amanda L, Clish Clary B, Anastasiou Dimitrios, Gilliland D Gary, Scadden David T, Guertin David A, Armstrong Scott A: mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. Cell stem cell 11(3): 429-39, Sep 2012.

Wen Qiang, Goldenson Benjamin, Silver Serena J, Schenone Monica, Dancik Vlado, Huang Zan, Wang Ling-Zhi, Lewis Timothy A, An W Frank, Li Xiaoyu, Bray Mark-Anthony, Thiollier Clarisse, Diebold Lauren, Gilles Laure, Vokes Martha S, Moore Christopher B, Bliss-Moreau Meghan, Verplank Lynn, Tolliday Nicola J, Mishra Rama, Vemula Sasidhar, Shi Jianjian, Wei Lei, Kapur Reuben, Lopez Cécile K, Gerby Bastien, Ballerini Paola, Pflumio Francoise, Gilliland D Gary, Goldberg Liat, Birger Yehudit, Izraeli Shai, Gamis Alan S, Smith Franklin O, Woods William G, Taub Jeffrey, Scherer Christina A, Bradner James E, Goh Boon-Cher, Mercher Thomas, Carpenter Anne E, Gould Robert J, Clemons Paul A, Carr Steven A, Root David E, Schreiber Stuart L, Stern Andrew M, Crispino John D: Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL. Cell 150(3): 575-89, Aug 2012.

Liu Jianing, Mercher Thomas, Scholl Claudia, Brumme Kristina, Gilliland D Gary, Zhu Nan: A functional role for the histone demethylase UTX in normal and malignant hematopoietic cells. Experimental hematology 40(6): 487-98.e3, Jun 2012.

Rubin Eric H, Gilliland D Gary: Drug development and clinical trials--the path to an approved cancer drug. Nature reviews. Clinical oncology 9(4): 215-22, Apr 2012.

Wernig G, Kharas M G, Mullally A, Leeman D S, Okabe R, George T, Clary D O, Gilliland D G: EXEL-8232, a small-molecule JAK2 inhibitor, effectively treats thrombocytosis and extramedullary hematopoiesis in a murine model of myeloproliferative neoplasm induced by MPLW515L. Leukemia 26(4): 720-7, Apr 2012.

Zhao Ling, Melenhorst Jan J, Alemu Lemlem, Kirby Martha, Anderson Stacie, Kench Maggie, Hoogstraten-Miller Shelley, Brinster Lauren, Kamikubo Yasuhiko, Gilliland D Gary, Liu P Paul: KIT with D816 mutations cooperates with CBFB-MYH11 for leukemogenesis in mice. Blood 119(6): 1511-21, Feb 2012.

Rice K L, Lin X, Wolniak K, Ebert B L, Berkofsky-Fessler W, Buzzai M, Sun Y, Xi C, Elkin P, Levine R, Golub T, Gilliland D G, Crispino J D, Licht J D, Zhang W: Analysis of genomic aberrations and gene expression profiling identifies novel lesions and pathways in myeloproliferative neoplasms. Blood cancer journal 1(11): e40, Nov 2011.

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Last updated: 07/30/2014
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