Ting-Chin David Shen, MD, PhD

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Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
421 Curie Boulevard
914 Biomedical Research Building II/III
Philadelphia, PA 19104
Education:
B.A. (Biochemistry)
Columbia College, Columbia University, 2004.
M.D. (Medicine)
College of Physicians and Surgeons, Columbia University, 2008.
Ph.D. (Cell and Molecular Biology)
Perelman School of Medicine, University of Pennsylvania, 2016.
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Description of Clinical Expertise

Abdominal Disorders
Abdominal Pain
Acid Peptic Disorders
Bowel Disorders
Colonoscopy
Constipation
Diarrhea
Endoscopy
Gastroesophageal Reflux Disease (GERD)
Gastrointestinal Disorders
Irritable Bowel Syndrome
Peptic Ulcer Disease (Stomach Ulcers)

Description of Research Expertise

My research interests lie at the intersection of microbiology, immunology, and metabolism with a focus on the gut microbiome and liver diseases. Currently, I have projects that span the spectrum of basic, translational, and clinical research. These include: 1) Investigating the role of bacterial urease in host and microbial nitrogen flux and metabolism, 2) Determining the metabolome and proteome of cirrhotic ascites for the prevention and treatment of spontaneous bacterial peritonitis, and 3) Characterizing the gut microbiota as a precipitant of acute-on-chronic liver failure.

Selected Publications

Friedman ES, Li Y, Shen TD, Jiang J, Chau L, Adorini L, Babakhani F, Edwards J, Shapiro D, Zhao C, Carr RM, Bittinger K, Li H, Wu GD : FXR-Dependent Modulation of the Human Small Intestinal Microbiome by the Bile Acid Derivative Obeticholic Acid. Gastroenterology 155(6): 1741-1752, August 2018 Notes: [Epub ahead of print]

Elliot S. Friedman, Ting-Chin David Shen, Yun Li, Jack Jiang, Lillian Chau, Luciano Adorini, Farah Babakhani, Jeffrey E. Edwards, Chunyu Zhao, Kyle Bittinger, Hongzhe Li, Gary D. Wu: FXR-Dependent Modulation of the Human Small Intestinal Microbiome by the Bile Acid Derivative Obeticholic Acid. European Association for the Study of the Liver June 2018 Notes: oral presentation.

Elliot S. Friedman, Ting-Chin David Shen, Yun Li, Jack Jiang, Lillian Chau, Luciano Adorini, Farah Babakhani, Jeffrey E. Edwards, Chunyu Zhao, Kyle Bittinger, Hongzhe Li, Gary D. Wu: FXR-Dependent Modification of the Human Small Intestinal Microbiome. Gastroenterology 154: S-1084, May 2018 Notes: oral presentation.

Shen TD, Pyrsopoulos N, Rustgi VK. : Microbiota and the Liver Liver Transplantation 24(4): 539-550, April 2018.

Ni J, Shen TD, Chen EZ, Bittinger K, Bailey A, Roggiani M, Sirota-Madi A, Friedman ES, Chau L, Lin A, Nissim I, Scott J, Lauder A, Hoffman C, Rivas G, Albenberg A, Baldassano RN, Braun J, Xavier RJ, Clish CB, Yudkoff M, Li H, Goulian M, Bushman FD, Lewis JD, Wu GD. : A Role for Bacterial Urease in Crohn’s Disease and Gut Dysbiosis. Science Translational Medicine 9(416), November 2017 Notes: pii: eaah6888. doi: 10.1126/scitranslmed.aah6888.

Josephine Ni, Ting-Chin David Shen, Eric Z. Chen, Aubrey Bailey, Manuela Roggiani, Alexandra Sirota-Madi, Elliot S. Friedman, Lillian Chau, Lindsey Albenberg, Robert N. Baldassano, Jonathan Braun, Ramnik Xavier, Clary B. Clish, Marc Yudkoff, Hongzhe Li, Mark Goulian, Frederic D. Bushman, James D. Lewis, Gary D. Wu: A Role for Bacterial Urease in Crohn's Disease and Gut Dysbiosis. Gastroenterology 154: S111, April 2017 Notes: oral presentation.

Shen TD: Diet and Gut Microbiota in Health and Disease. Intestinal Microbiome: Functional Aspects in Health and Disease 88: 117-126, 2017.

Shen TD, Chehoud C, Ni J, Hsu E, Chen YY, Bailey A, Laughlin A, Bittinger K, Bushman FD, Wu GD. : Dietary Regulation of the Gut Microbiota Engineered by a Minimal Defined Bacterial Consortium. PLOS ONE 11(5): e0155620, May 2016 Notes: eCollection 2016.

Shen TD, Albenberg LA, Bittinger K, Chehoud C, Chen YY, Judge CA, Chau L, Ni J, Sheng M, Lin A, Wilkins BJ, Buza EL, Lewis JD, Daikhin Y, Nissim I, Yudkoff M, Bushman FD, Wu GD. : Engineering the Gut Microbiota to Treat Hyperammonemia. Journal of Clinical Investigation 125(7): 2841-50, July 2015.

Ting-Chin D. Shen, Lindsey Albenberg, Kyle Bittinger, Christel Chehoud, Ying-Yu Chen, Colleen Judge, Lillian Chau, Mike Sheng, Andrew Lin, Benjamin J. Wilkins, James Lewis, Yevgeny I. Daikhin, Ilana Nissim, Marc Yudkoff, Frederic D. Bushman, Gary D. Wu: Engineering the Gut Microbiota to Treat Hyperammonemia. Gastroenterology 148: Page S-74, April 2015 Notes: oral presentation.

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Last updated: 06/05/2019
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