Ting-Chin David Shen, MD, PhD
Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine
Contact information
421 Curie Boulevard
914 Biomedical Research Building II/III
Philadelphia, PA 19104
914 Biomedical Research Building II/III
Philadelphia, PA 19104
Education:
B.A. (Biochemistry)
Columbia College, Columbia University, 2004.
M.D. (Medicine)
College of Physicians and Surgeons, Columbia University, 2008.
Ph.D. (Cell and Molecular Biology)
Perelman School of Medicine, University of Pennsylvania, 2016.
Permanent linkB.A. (Biochemistry)
Columbia College, Columbia University, 2004.
M.D. (Medicine)
College of Physicians and Surgeons, Columbia University, 2008.
Ph.D. (Cell and Molecular Biology)
Perelman School of Medicine, University of Pennsylvania, 2016.
Description of Clinical Expertise
Abdominal DisordersAbdominal Pain
Acid Peptic Disorders
Bowel Disorders
Colonoscopy
Constipation
Diarrhea
Endoscopy
Gastroesophageal Reflux Disease (GERD)
Gastrointestinal Disorders
Irritable Bowel Syndrome
Peptic Ulcer Disease (Stomach Ulcers)
Description of Research Expertise
My research is focused on the gut-liver axis, with projects that span the spectrum of basic, translational, and clinical research. These include investigations on the effects of the gut microbiota on hepatic drug and xenobiotic metabolism, gut microbial signatures in chronic liver diseases, and mixed meal tolerance testing in cirrhosis.Selected Publications
Chen RA, Wu WK, Panyod S, Liu PY, Chuang HL, Chen YH, Lyu Q, Hsu HC, Ling TL, Shen TD, Yang YT, Zou HB, Huang HS, Lin YE, Chen CC, Ho CT, Lai HC, Wu MS, Hsu CC, Sheen LY. : Dietary Exposure to Antibiotic Residues Facilitates Metabolic Disorder by Altering the Gut Microbiota and Bile Acid Composition. mSystems June 2022.Panyod S, Wu WK, Chen PC, Chong KV, Yang YT, Chuang HL, Chen CC, Chen RA, Liu PY, Chung CH, Huang HS, Lin AY, Shen TD, Yang KC, Huang TF, Hsu CC, Ho CT, Kao HL, Orekhov AN, Wu MS, Sheen LY.: Atherosclerosis amelioration by allicin in raw garlic through gut microbiota and trimethylamine-N-oxide modulation. NPJ Biofilms Microbiomes January 2022.
Saiman Y*, Shen TD*, Lund PJ, Gershuni VM, Jang C, Patel S, Jung S, Furth EE, Friedman ES, Chau L, Garcia BA, Wu GD.: Global Microbiota-Dependent Histone Acetylation Patterns Are Irreversible and Independent of Short Chain Fatty Acids. Hepatology December 2021.
Shen TD, Daniel SG, Patel S, Kaplan E, Phung L, Lemelle-Thomas K, Chau L, Herman L, Trisolini C, Stonelake A, Toal E, Khungar V, Bittinger K, Reddy KR, Wu GD. : The Mucosally-Adherent Rectal Microbiota Contains Features Unique to Alcohol-Related Cirrhosis. Gut Microbes November 2021.
Friedman ES, Li Y, Shen TD, Jiang J, Chau L, Adorini L, Babakhani F, Edwards J, Shapiro D, Zhao C, Carr RM, Bittinger K, Li H, Wu GD : FXR-Dependent Modulation of the Human Small Intestinal Microbiome by the Bile Acid Derivative Obeticholic Acid. Gastroenterology 155(6): 1741-1752, August 2018 Notes: [Epub ahead of print]
Elliot S. Friedman, Ting-Chin David Shen, Yun Li, Jack Jiang, Lillian Chau, Luciano Adorini, Farah Babakhani, Jeffrey E. Edwards, Chunyu Zhao, Kyle Bittinger, Hongzhe Li, Gary D. Wu: FXR-Dependent Modulation of the Human Small Intestinal Microbiome by the Bile Acid Derivative Obeticholic Acid. European Association for the Study of the Liver June 2018 Notes: oral presentation.
Elliot S. Friedman, Ting-Chin David Shen, Yun Li, Jack Jiang, Lillian Chau, Luciano Adorini, Farah Babakhani, Jeffrey E. Edwards, Chunyu Zhao, Kyle Bittinger, Hongzhe Li, Gary D. Wu: FXR-Dependent Modification of the Human Small Intestinal Microbiome. Gastroenterology 154: S-1084, May 2018 Notes: oral presentation.
Shen TD, Pyrsopoulos N, Rustgi VK. : Microbiota and the Liver Liver Transplantation 24(4): 539-550, April 2018.
Ni J, Shen TD, Chen EZ, Bittinger K, Bailey A, Roggiani M, Sirota-Madi A, Friedman ES, Chau L, Lin A, Nissim I, Scott J, Lauder A, Hoffman C, Rivas G, Albenberg A, Baldassano RN, Braun J, Xavier RJ, Clish CB, Yudkoff M, Li H, Goulian M, Bushman FD, Lewis JD, Wu GD. : A Role for Bacterial Urease in Crohn’s Disease and Gut Dysbiosis. Science Translational Medicine 9(416), November 2017 Notes: pii: eaah6888. doi: 10.1126/scitranslmed.aah6888.
Josephine Ni, Ting-Chin David Shen, Eric Z. Chen, Aubrey Bailey, Manuela Roggiani, Alexandra Sirota-Madi, Elliot S. Friedman, Lillian Chau, Lindsey Albenberg, Robert N. Baldassano, Jonathan Braun, Ramnik Xavier, Clary B. Clish, Marc Yudkoff, Hongzhe Li, Mark Goulian, Frederic D. Bushman, James D. Lewis, Gary D. Wu: A Role for Bacterial Urease in Crohn's Disease and Gut Dysbiosis. Gastroenterology 154: S111, April 2017 Notes: oral presentation.