Timothy H Lucas Jr., M.D., Ph.D., M.H.C.I.
3rd Floor Silverstein
Philadelphia, PA 19104
B.S. (Neurobiological Sciences & Psychobiology)
University of Florida, 1996.
University of Florida, 2001.
Ph.D. (Physiology & Biophysics)
University of Washington, 2009.
M.H.C.I. (Health Care Innovation, Health Policy Dept & Wharton)
University of Pennsylvania, 2019.
Description of Clinical ExpertiseEpilepsy Surgery
Minimally invasive neurosurgery
Cortisectomy / Topectomy
Corpus Callostomy / Functional Disconnection Surgery
Stereotactic and Functional Neurosurgery
Movement Disorder Surgery (Parkinson's Disease, Essential Tremor, Dystonia)
Glioma Surgery (Low Grade, High Grade, Adult, Pediatric)
Brain Mapping (Speech, Motor, Sensory; cortical and subcortical)
Extraoperative Brain Mapping
Brain-machine interface / Brain-computer interface
Skull base surgery
Eloquent Cortex Lesions (motor, sensory, speech, visual cortex)
Traumatic brain and spine injury
Description of Research ExpertiseBrain-machine interface / Brain-computer interface
Motor Cortex Functional Organization
Speech and Language Organization
Basal Ganglia - Cortical Interactions
Cortical/Basal Ganglia Stimulation
Cortical Spike and Local Field Recording
Basal Ganglia Spike and Local Field Recording
Spinal Cord Stimulation and Mapping
Selected PublicationsRichardson, AG, Y Ghenbot, X Liu, H Has, C Rinehart, S DeLuccia, ST Maldonado, G Boyek, M Zhang, F Aflatouni, J Van der Spiegel, TH Lucas: Learning active sensing strategies using a sensory brain-machine interface. PNAS 116(35): 17509-14, August 2019.
Kini, LG, JM Bernabei, F Mikhail, P Hadar, P Shah, AN Khambhati, K Oechsel, R Archer, J Boccanfuso, E Conrad, RT Shinohara, J Stein, S Das, A Kheder, TH Lucas, KA Davis, DS Bassett, B Litt: Virtual resection predicts surgical outcome for drug resistant epilepsy. Brain In press: 1-14, October 2019 Notes: Available online ahead of print.
Khambhati AN, AE Kahn, J Costantini, Y Ezzyat, E Solomon, RE Gross, BC Jobst, SA Sheth, KA Zaghloul, G Worrell, S Seger, BC Lega, S Weiss, MR Sperling, R Gorniak, SR Das, JM Stein, DS Rizzuto, MJ Kahana, TH Lucas, KA Davis, JI Tracey, BS Bassett. : Functional control of electrophysiological network architecture using direct neurostimulation in humans. Network Neuroscience, MIT Press 3(3): 848-877, April 2019.
Stiso, J, AN Khambhati, T Mernara, AE Kahn, J Stein, SR Das, R Gorniak, J Tracy, B Litt, KA Davis, F Pasqualetti, TH Lucas, DS Bassett: White matter network architecture guides direct electrical stimulation through optimal state transitions. Cell Reports 28(10): 2554-66, September 2019.
Shah P, JM Bernadbei, L Kini, A Ashourvan, J Boccanfuso, R Archer, K Oechsel, SR Das, JM Stein, TH Lucas, DS Bassett, KA Davis and B Litt: High intertidal connectivity within the resection zone is associated with favorable post-surgical outcomes in focal epilepsy patients. NeuroImage 23: 1-9, December 2019 Notes: Available online ahead of print.
Hitti FL, M Piazza, S Sinha, S Kvint, E Hudgins, G Baltuch, R Diaz-Arrastia, KA Davis, B Litt, TH Lucas, HI Chen: Surgical Outcomes in Post-Traumatic Epilepsy: A Single Institutional Experience. Operative Neurosurgery In press: 1-7, March 2019 Notes: Available online; Epub Ahead of Print.
Vitale F, M Allen, K Cullen, AG Richardson, TH Lucas, B Litt: Biomimetic extracellular matrix coatings improve the chronic biocompatibility of microfabricated subdural microelectrode arrays. PLoS One 13(11): e0206137, Nov 2018.
Driscoll N, AG Richardson, K Maleski, B Anasori, O Adewole, P Lelyukh, L Escobedo, K Cullen , TH Lucas, Y Gogotsi, F Vitale: Two-Dimensional TiC MXene for High-Resolution Neural Interfaces. ACS Nano: Journal of American Chemical Society 12(10): 10419-10429, Oct 2018.
Gourmaud S, H Shou, DJ Irwin, K Sansalone, L Jacobs, TH Lucas, ED Marsh, KA Davis, FE Jensen, DM Talos: Alzheimer's like amyloid and tau pathology associated with cognitive deficit in temporal lobe epilepsy. Brain in print(in print), 2019.
Agarwal Prateek, Abdullah Kalil G, Ramayya Ashwin G, Nayak Nikhil R, Lucas Timothy H: A Retrospective Propensity Score-Matched Early Thromboembolic Event Analysis of Prothrombin Complex Concentrate vs Fresh Frozen Plasma for Warfarin Reversal Prior to Emergency Neurosurgical Procedures. Neurosurgery 82(6): 877-886, Jun 2018.