Alejandro Carabe-Fernandez, Ph.D.

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Assistant Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Department: Radiation Oncology

Contact information
Hospital of the University of Pennsylvania
Department of Radiation Oncology
TRC 4 West, 4-324W
3400 Civic Center Boulevard
Phiadelphia, PA 19104
Office: (215) 614-1605
MPhys (Physics with Medical Technology)
University of Hull, 2000.
MSc (Medical Physics)
University of Glasgow, 2002.
Ph.D. (Radiobiology)
Imperial College, 2008.
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Description of Clinical Expertise

Proton and convencional radiotherapy

Description of Research Expertise

Clinical and theoretical radiobiology
High-LET radiobiology and radiotherapy
Radiobiological Optimization
TCP/NTCP specific for high-LET radiations
Repair kinetics modeling
Proton Arc Thereapy

Selected Publications

Perales, Álvaro; Baratto-Roldán, Anna; Kimstrand, Peter; Cortes-Giraldo, Miguel; Carabe, Alejandro: "Parameterising microdosimetric distributions of mono-energetic proton beams for fast estimates of yD and y*" Biomedical Physics & Engineering Express 2019.

Paganetti H; Blakely E; Carabe-Fernandez A; Carlson DJ; Das IJ; Dong L; Grosshans D; Held KD; Mohan R; Moiseenko V; Niemierko A; Stewart RD and Willers H: Report of the AAPM TG-256 on the relative biological effectiveness of proton beams in radiation therapy. Medical Physics 2019.

Ramin Abolfath, Yusuf Helo, Lawrence Bronk, Alejandro Carabe, David Grosshans, Radhe Mohan: Renormalization of Radiobiological response functionsby energyloss fluctuationsand complexities in chromosome aberration induction: a multi-scale cell deactivation theory for proton therapy. European Physical Journal D. Andrey V. Solov'yov (eds.). 2019 Notes: d180263.

Shampa Chatterjee, Ralph A. Pietrofesa, Kyewon Park, Jian-Qin Tao, Thais Sielecki, Alejandro Carabe-Fernandez, Abigail T. Berman, Constantinos Koumenis, and Melpo Christofidou-Solomidou : LGM2605 Reduces Space Radiation-Induced NLRP3 Inflammasome Activation and Damage in In Vitro Lung Vascular Networks Radiation Research Society 2018.

Ulmer W, Carabe-Fernandez A: Aspect of physical principles of the proton therapy with inclusion of nuclear interactions. Journal of Proton Therapy (ISSN 2469-5491) 3: 311, 2017.

A. Baratto-Roldán, P. Kimstrand, Á. Perales Molina, A. Carabe, M. A. Cortés-Giraldo: Relation between dose average linear energy transfer and dose mean lineal energy calculated for proton therapy beams off axis: A study with the Geant4 toolkit. Physica Medica 42(1): 42-43, 2017.

N Delso , K Stutzer , M Kirk , S Huang , D Sanchez-Parcerisa , L Lin , G Freedman , J Metz , E Abel , A Carabe-Fernandez: Proton Modulated Arc Therapy Using Mono-Energetic Beams for the Treatment of Left-Sided Breast Cancer. Medical Physics 2017.

Sanchez-Parcerisa D, Kirk M, Fager M, Burgdorf B, Stowe M, Solberg T, Carabe A.: Range optimization for mono- and bi-energetic proton modulated arc therapy with pencil beam scanning. Phys Med Biol. 61(21): N565-N574, November 2016.

Sanchez-Parcerisa D, Cortés-Giraldo MA, Dolney D, Kondrla M, Fager M, Carabe A. : Analytical calculation of proton linear energy transfer in voxelized geometries including secondary protons. Phys Med Biol. 61(4): 1705-21, Feb 2016.

Alan Mitteer R, Wang Y, Shah J, Gordon S, Fager M, Butter PP, Jun Kim H, Guardiola-Salmeron C, Carabe-Fernandez A, Fan Y. : Proton beam radiation induces DNA damage and cell apoptosis in glioma stem cells through reactive oxygen species. Sci Rep. 5: 13961, Sep 2015 Notes: DOI: 10.1038/srep13961

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Last updated: 05/20/2019
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