Alan T. Tang, MD, PhD
Instructor A of Medicine (Cardiovascular Medicine)
Department: Medicine
Contact information
Division of Cardiology and Department of Medicine
University of Pennsylvania Perelman School of Medicine
3400 Civic Center Blvd
Philadelphia, PA 19104
University of Pennsylvania Perelman School of Medicine
3400 Civic Center Blvd
Philadelphia, PA 19104
Education
BS (Biochemistry with Highest Distinction, Mathematics)
University of Illinois at Chicago, 2012.
MD/PhD (Medical Scientist Training Program)
Perelman School of Medicine at the University of Pennsylvania, 2020.
Permanent linkBS (Biochemistry with Highest Distinction, Mathematics)
University of Illinois at Chicago, 2012.
MD/PhD (Medical Scientist Training Program)
Perelman School of Medicine at the University of Pennsylvania, 2020.
ORCID identifier 
0000-0003-1422-0349
Selected Publications
Tang AT, Lee B, Wang M, Griffin J, Lai L, Scherrer-Crosbie M, Kelly DP, Margulies KB, Kahn ML: Endocardial GPR126 senses mechanical stretch to maintain cardiac filling" Gordon Research Conference on Endothelial Cell Phenotypes in Health and Disease July 2026 Notes: Poster presentation.Li L, Castro M, Hongo H, Ren J, Shenkar R, Jabarkheel R, Gao S, Narayan S, Frankfurter M, Tang AT, Yang J, Chen M, Bockman J, Mericko-Ishizuka P, Alcazar R, Sader G, Iqbal J, Kinkade S, Lightle R, Ressler AK, Qu X, Baldwin HS, Marchuk DA, Awad IA, Burkhardt JK, Potente M, Kahn ML.: TIE2 links MEKK3-KLF2/4 and PI3K signaling in cerebral cavernous malformation. J Exp Med 223(5): e20251374, May 2026.
Sung DC, Ahanger HA, Narayan S, Pace JA, Chen M, Yang J, Gao S, Keller TCS 4th, Bockman J, Chen X, Nguyen E, Tang AT, Mericko-Ishizuka P, Maillard I, Kahn ML.: Dll4 assembles the umbilical cord and placental vasculature. JCI Insight 11(7): e194461, Feb 2026.
Chen X, Tober J, Dominguez M, Tang AT, Bockman J, Yang J, Mani S, Lee CN, Chen M, Thillaikumaran T, Mericko-Ishizuka P, Mainigi M, Speck NA, Kahn ML.: Lineage tracing studies suggest that the placenta is not a de novo source of hematopoietic stem cells. PLoS Biol 23(1): e3003003, Jan 2025.
Tang AT, Wang M, Leu NA, Griffin J, Ling L, Margulies KB, Kahn ML: “Endocardial GPR126 is a mechanoreceptor utilizing versican to remodel the heart.” AAP/ASCI/APSA Joint Meeting 2025 Notes: Poster Presentation.
Wong J, Zhao G, Adams-Tzivelekidis S, Wen H, Chandrasekaran P, Michki SN, Gentile ME, Singh M, Kass-Gergi S, Mendoza M, Holcomb NP, Li X, Tang AT, Negretti NM, Sucre JMS, Frank DB, Vaughan AE.: Dynamic behavior and lineage plasticity of the pulmonary venous endothelium. Nat Cardiovasc Res 3(12): 1584-1600, Dec 2024.
Yuki K, Vallon M, Ding J, Rada CC, Tang AT, Vilches-Moure JG, McCormick AK, Henao Echeverri MF, Alwahabi S, Braunger BM, Ergün S, Kahn ML, Kuo CJ.: GPR124 regulates murine brain embryonic angiogenesis and BBB formation by an intracellular domain-independent mechanism. Development 151(11): dev202794, Jun 2024.
Gao S, Tang AT, Wang M, Buchholz DW, Imbiakha B, Yang J, Chen X, Hewins P, Mericko-Ishizuka P, Leu NA, Sterling S, August A, Jurado KA, Morrisey EE, Aguilar-Carreno H, Kahn ML.: Endothelial SARS-CoV-2 infection is not the underlying cause of COVID-19-associated vascular pathology in mice. Front Cardiovasc Med 10: 1266276, Sep 2023 Notes: doi: 10.3389/fcvm.2023.1266276.
Gao S, Tang AT, Wang M, Buchholz DW, Imbiakha B, Yang J, Chen X, Hewins P, Mericko-Ishizuka P, Leu NA, Sterling S, August A, Jurado KA, Morrisey EE, Aguilar-Carreno H, Kahn ML.: Endothelial SARS-CoV-2 infection is not the underlying cause of COVID19-associated vascular pathology in mice. bioRxiv 24: 550352, Jul 2023 Notes: doi: 10.1101/2023.07.24.550352.
Tang AT, Buchholz DW, Szigety KM, Imbiakha B, Gao S, Frankfurter M, Wang M, Yang J, Hewins P, Mericko-Ishizuka P, Leu NA, Sterling S, Monreal IA, Sahler J, August A, Zhu X, Jurado KA, Xu M, Morrisey EE, Millar SE, Aguilar HC, Kahn ML.: Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection. PLoS Biol 21(2): e3001989, Feb 2023.