Perelman School of Medicine/ Faculty Search/ Robert K Doot

Robert K Doot, Ph.D.

Research Assistant Professor of Radiology

Department: Radiology

Contact information

Perelman School of Medicine
University of Pennsylvania
415 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104-6021

Office: (215) 662-6781
Fax: (215) 573-3880

Education:
B.S.E. (Chemical Engineering)
University of Michigan, Ann Arbor, 1992.
M.S. (Bioengineering)
University of Washington, Seattle, 2005.
Ph.D. (Bioengineering and Nanotechnology)
University of Washington, Seattle., 2008.

Permanent link

Perelman School of Medicine > Faculty > Search

Description of Research Expertise

Positron Emission Tomography (PET) tracer selection and methodology development
Kinetic analysis of dynamic PET images
Quantitative molecular imaging
PET/CT calibration

Selected Publications

Doot R. K., L. A. Pierce, D. Byrd, B. Elston, K. C. Allberg, and P. E. Kinahan: "Biases in multicenter longitudinal PET standardized uptake value measurements." Transl Oncol 7(1): 48-54, Feb 2014.

Doot, R. K., B. F. Kurland, P. E. Kinahan, and D. A. Mankoff: "Design considerations for using PET as a response measure in single site and multicenter clinical trials." Acad Radiol 19(2): 184-90, 2012.

Doot R. K., T. Thompson, B. E. Greer, K. C. Allberg, H. M. Linden, D. A. Mankoff, and P. E. Kinahan: "Early experiences in establishing a regional quantitative imaging network for PET/CT clinical trials." Magn Reson Imaging 30(9): 1291-300, 2012.

Dunnwald L. K., R. K. Doot, J. M. Specht, J. R. Gralow, G. K. Ellis, R. B. Livingston, H. M. Linden, V. Gadi, B. F. Kurland, E. K. Schubert, M. Muzi, and D. A. Mankoff: "PET tumor metabolism in locally advanced breast cancer patients undergoing neoadjuvant chemotherapy: Value of static versus kinetic measures of fluorodeoxyglucose uptake." Clin Cancer Res 17(8): 2400-9, 2011.

Doot, R. K., M. Muzi, L. M. Peterson, E. K. Schubert, J. R. Gralow, J. M. Specht, and D. A. Mankoff: "Kinetic analysis of 18F-fluoride PET images of breast cancer bone metastases." J Nucl Med 51(4): 521-7, 2010.

Doot, R. K., J. S., Scheuermann, P. E. Christian, J. S. Karp, and P. E. Kinahan: "Instrumentation factors affecting variance and bias of quantifying tracer uptake with PET/CT." Med Phys 37(11): 6035-46, 2010.

Partridge, S. C., R. K. Vanantwerp, R. K. Doot, X. Chai, B. F. Kurland, P. R. Eby, J. M. Specht, L. K. Dunnwald, E. K. Schubert, C. D. Lehman, D. A. Mankoff: "Association between serial dynamic contrast-enhanced MRI and dynamic 18F-FDG PET measures in patients undergoing neoadjuvant chemotherapy for locally advanced breast cancer." J Magn Reson Imaging 32(5): 1124-31, 2010.

Dunnwald L. K., J. R. Gralow, G. K. Ellis, R. B. Livingston, H. M. Linden, J. M. Specht, R. K. Doot, T. J. Lawton, W. E. Barlow, B. F. Kurland, E. K. Schubert, and D. A. Mankoff: "Tumor metabolism and blood flow changes by PET: Relation to survival in patients treated with neoadjuvant chemotherapy for locally advanced breast cancer." J Clin Oncol 26(27): 4449-57, 2008.

Doot, R. K., L. K. Dunnwald, E. K. Schubert, M. Muzi, L. M. Peterson, P. E. Kinahan, B. F. Kurland, and D. A. Mankoff: "Dynamic and static approaches to quantifying 18F-FDG uptake for measuring cancer response to therapy, including the effect of granulocyte CSF." J Nucl Med 48(6): 920-5, 2007.

Doot, R. K., H. Hess, and V. Vogel: "Engineered networks of oriented microtubule filaments for directed cargo transport." Soft Matter 3: 349-56, 2007 Notes: COVER.