Robert K. Doot, Ph.D.
Research Assistant Professor of Radiology
Department: Radiology
Contact information
Perelman School of Medicine
University of Pennsylvania
John Morgan Building, Room 160A
3620 Hamilton Walk FL 1
Philadelphia, PA 19104-4800
University of Pennsylvania
John Morgan Building, Room 160A
3620 Hamilton Walk FL 1
Philadelphia, PA 19104-4800
Office: (215) 573-6016
Fax: (215) 573-3880
Fax: (215) 573-3880
Education:
B.S.E. (Chemical Engineering)
University of Michigan, Ann Arbor, 1992.
M.S. (Bioengineering)
University of Washington, Seattle, 2005.
Ph.D. (Bioengineering and Nanotechnology)
University of Washington, Seattle., 2008.
Permanent linkB.S.E. (Chemical Engineering)
University of Michigan, Ann Arbor, 1992.
M.S. (Bioengineering)
University of Washington, Seattle, 2005.
Ph.D. (Bioengineering and Nanotechnology)
University of Washington, Seattle., 2008.
Description of Research Expertise
Positron Emission Tomography (PET) tracer selection and methodology developmentKinetic analysis of dynamic PET images
Neuroimaging of drug addiction
Quantitative molecular imaging
PET/CT calibration
Selected Publications
Dubroff, J. G., R. K. Doot, M. Falcone, R. Schnoll, R. F. Tyndale, A. L. Brody, C. Hou, A. Schmitz, and C. Lerman: "Decreased nicotinic receptor availability in smokers with slow rates of nicotine metabolism." J Nucl Med. 56(11): 1724-9, Nov 2015.Doot, R. K., E. S. McDonald, and D. A. Mankoff: "Role of PET quantitation in the monitoring of cancer response to treatment: review of approaches and human clinical trials." Clin Transl Imaging. 2(4): 295-303, Aug 2014.
Doot, R. K., L. A. Pierce, D. Byrd, B. Elston, K. C. Allberg, and P. E. Kinahan: "Biases in multicenter longitudinal PET standardized uptake value measurements." Transl Oncol. 7(1): 48-54, Feb 2014.
Doot, R. K., B. F. Kurland, P. E. Kinahan, and D. A. Mankoff: "Design considerations for using PET as a response measure in single site and multicenter clinical trials." Acad Radiol. 19(2): 184-90, Feb 2012.
Doot R. K., T. Thompson, B. E. Greer, K. C. Allberg, H. M. Linden, D. A. Mankoff, and P. E. Kinahan: "Early experiences in establishing a regional quantitative imaging network for PET/CT clinical trials." Magn Reson Imaging. 30(9): 1291-300, Nov 2012.
Dunnwald L. K., R. K. Doot, J. M. Specht, J. R. Gralow, G. K. Ellis, R. B. Livingston, H. M. Linden, V. Gadi, B. F. Kurland, E. K. Schubert, M. Muzi, and D. A. Mankoff: "PET tumor metabolism in locally advanced breast cancer patients undergoing neoadjuvant chemotherapy: Value of static versus kinetic measures of fluorodeoxyglucose uptake." Clin Cancer Res. 17(8): 2400-9, Apr 2011.
Doot, R. K., M. Muzi, L. M. Peterson, E. K. Schubert, J. R. Gralow, J. M. Specht, and D. A. Mankoff: "Kinetic analysis of 18F-fluoride PET images of breast cancer bone metastases." J Nucl Med. 51(4): 521-7, Mar 2010.
Doot, R. K., J. S., Scheuermann, P. E. Christian, J. S. Karp, and P. E. Kinahan: "Instrumentation factors affecting variance and bias of quantifying tracer uptake with PET/CT." Med Phys. 37(11): 6035-46, Nov 2010.
Doot, R. K., L. K. Dunnwald, E. K. Schubert, M. Muzi, L. M. Peterson, P. E. Kinahan, B. F. Kurland, and D. A. Mankoff: "Dynamic and static approaches to quantifying 18F-FDG uptake for measuring cancer response to therapy, including the effect of granulocyte CSF." J Nucl Med. 48(6): 920-5, May 2007.
Doot, R. K., H. Hess, and V. Vogel: "Engineered networks of oriented microtubule filaments for directed cargo transport." Soft Matter. 3(3): 349-56, Jul 2007 Notes: COVER.