Francis X. McGowan, Jr., MD, FAAP

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Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care

Contact information
Department of Anesthesiology and Critical Care Medicine
The Children's Hospital of Philadelphia
34th Street and Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-6515
Fax: 215-590-1924
MD (Medicine)
Duke University School of Medicine, 1983.
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Description of Clinical Expertise

1. Pediatric anesthesiology and perioperative medicine
2. Pediatric cardiac anesthesiology and perioperative medicine
3. Adult congenital cardiac anesthesiology and perioperative medicine

Description of Research Expertise

1. Mechanisms of infant myocardial injury and protection
2. Mitochondrial mechanisms of myocardial injury; cardiac mitochondrial function, damage, and biogenesis
4. Inflammatory mechanisms in ischemia-reperfusion and cardiopulmonary bypass
5. Intravenous oxygen delivery

Selected Publications

Himebauch AS, Yehya N, Wan Y, Conlon T, Kilbaugh TJ, McGowan FX, Mercer-Rosa L: Early Right Ventricular Systolic Dysfunction and Pulmonary Hypertension Are Associated With Worse Outcomes in Pediatric Acute Respiratory Distress Syndrome. Crit Care Medd 46(11): 51055-e1062, November 2018 Notes: Epub ahead of print.

Lasso A, Nam HH, Dinh PV, Pinter C, Fillion-Robin JC, Pieper S, Jhaveri S, Vimort JB, Martin K, Asselin M, McGowan FX, Kikinis R, Fichtinger G, Jolley MA: Interaction with Volume-Rendered Three-Dimensional Echocardiographic Images in Virtual Reality. J Am Soc Echocardiog 31(10): 1158-1160, October 2018.

Olbrecht VA, Skowno J, Marchesini V, Ding L, Jiang Y, Ward CG, Yu G, Liu H, Schurink B, Vutskits L, de Graaff JC, McGowan FX Jr, von Ungern-Sternberg BS, Kurth CD, Davidson A: An International, Multicenter, Observational Study of Cerebral Oxygenation during Infant and Neonatal Anesthesia. Anesthesiology 128(1): 85-96, January 2018.

Scanlan AB, Nguyen AV, Ilina A, Lasso A, Cripe L, Jegatheeswaran A, Silvestro E, McGowan FX, Mascio CE, Fuller S, Spray TL, Cohen MS, Fichtinger G, Jolley MA: Comparison of 3D Echocardiogram-Derived 3D Printed Valve Models to Molded Models for Simulated Repair of Pediatric Atrioventricular Valves. Pediatr Cardiol 39(3): 538-547, 2018 Notes: Epub ahead of print.

Kussman BD, Laussen PC, Benni PB, McGowan FX Jr, McElhinney DB: Cerebral Oxygen Saturation in Children with Congenital Heart Disease and Chronic Hypoxemia. Anesth Analg 125(1): 234-240, 2017.

Pouch AM, Aly AH, Lasso A, Nguyen AV, Scanlan AB, McGowan FX, Fichtinger G, Gorman RC, Gorman JH, Yushkevich PA, Jolley MA.: Image segmentation and modeling of the pediatric tricuspid valve in hypoplastic left heart syndrome. Lect Note Comput Sci/FIMH 2017 10263: 95-105, 2017.

Perry DA, Salvin JW, Romfh P, Chen P, Krishnamurthy K, Thomson LM, Polizzotti BD, Vakshoori D, McGowan FX, Kheir JN.: Responsive monitoring of mitochondrial redox states in heart muscle predicts impending cardiac arrest. Science Transl Med 9(408): pii: eaan0117. doi: 10.1126/scitranslmed.aan0117. 2017.

Levy RJ, Herbstman JB, Bosnjak ZJ, Loepke AW, McGowan FX: Biomarkers, Genetics, and Epigenetic Studies to Explore the Neurocognitive Effects of Anesthesia in Children. J Neurosurg Anesth Page: 384-388, 2016 Notes: Epub ahead of print.

Ward CG, Hines SJ, Maxwell LG, McGowan FX, Sun LS: Neurotoxicity, general anesthesia in young children, and a survey of current pediatric anesthesia practice at US teaching institutions. Pediatric Anesthesia 26(1): 60-65, 2016.

Thomson LM, Seekell RP, McGowan FX, Kheir JN, Polizzotti BD: Freeze-thawing at point-of-use to extend shelf stability of lipid-based oxygen microbubbles for intravenous oxygen delivery. Colloids and Surfaces A: Physiochem Eng Aspects 500: 72-8, 2016.

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Last updated: 10/30/2018
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