Chenbo Zeng, PhD

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Research Assistant Professor of Radiology
Department: Radiology

Contact information
Department of Radiology
University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-349-5607
B.A. (Biochemistry)
Jilin University, Changchun, P.R. China, 1985.
M.S. (Biochemistry)
Jilin University, Changchun, P.R. China, 1988.
Ph.D (Biochemistry)
Iowa State University, Ames, Iowa, 1996.
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Description of Research Expertise

Evaluating sigma-2 receptor radiotracers as a predictor of drug response in breast cancer using positron emission tomography technology

Studying biological functions of the sigma-2 receptor in breast cancer and in the central nervous system

Selected Publications

Zeng C, Weng CC, Schneider ME Jr, Puentes L, Riad A, Xu K, Makvandi M, Jin L, Hawkins WG, Mach RH.: TMEM97 and PGRMC1 do not mediate sigma-2 ligand-induced cell death. Cell Death Discov. 5: 58, 2019.

Riad A, Zeng C, Weng CC, Winters H, Xu K, Makvandi M, Metz T, Carlin S, Mach RH.: Sigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex. Sci Rep. 8: 16845, 2018.

Elizabeth S. McDonald, Julia Mankoff, Mehran Makvandi, Wenhua Chu, Yunxiang Chu, Robert H Mach, Chenbo Zeng: Sigma-2 ligands and PARP inhibitors synergistically trigger cell death in breast cancer cells Biochemical and Biophysical Research Communications 486: 788-795 2017 Notes: Epub ahead of print.

Chenbo Zeng and Robert H. Mach: The Evolution of the Sigma-2 Receptor from Obscure Binding Site to Bona Fide Therapeutic Target. Adv Exp Med Biol. Sigma Receptors: Their Role in Disease and as Therapeutic Targets. Sylvia B. Smith and Tsung-Ping Su (eds.). Springer, 964: 49-61, 2017.

Zeng C, Garg N, Mach RH.: The PGRMC1 Protein Level Correlates with the Binding Activity of a Sigma-2 Fluorescent Probe (SW120) in Rat Brain Cells. Mol Imaging Biol. 18: 172-9, 2016.

Zeng, C.,Rothfuss, J.M., Zhang, J., Vangveravong, S., Chu, W.,Li, S., Tu, Z., Xu, J., Mach, R.H.: Functional assays to define agonists and antagonists of the sigma-2 receptor. Anal Biochem. 448C:68-74, 2014.

Zeng, C., Vangveravong, S., McDunn, J.E., Hawkins, W. G., Mach, R.H.: Sigma-2 receptor ligand as a novel method for delivering a SMAC mimetic drug for treating ovarian cancer. Br J Cancer 109:2368-2377, 2013.

Mach, R.H., Zeng, C., Hawkins, W. G.: A novel protein for the imaging and treatment of cancer. J Med Chem. 56:7137-7160, 2013.

Zeng, C., Pan,F., Jones, L.A., Lim, M.M., Griffin, E.A., Sheline, Y.I., Mintun, M.A., Holtzman, D.M., Mach, R.H.: Evaluation of 5-ethynyl-2’-deoxyruidine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system. Brain Res 1319, 21-32, 2010.

Zeng, C., Vangveravong, S., Xu, J., Chang, K.C., Hotchkiss, R.S., Wheeler, K.T., Shen, D., Zhuang, Z.P., Kung, H., Mach, R.H.: Subcellular localization of sigma-2 receptors in breast cancer cells using two-photon and confocal microscopy. Cancer Res 67, 6708-6716, 2007.

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Last updated: 09/08/2020
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